A5101915670- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- MRI in cancer diagnosis
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Endometrial and Cervical Cancer Treatments
- Medical Imaging Techniques and Applications
- RNA modifications and cancer
- Advanced MRI Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Advanced X-ray and CT Imaging
- Cancer-related molecular mechanisms research
- Oral health in cancer treatment
- Ovarian cancer diagnosis and treatment
- Sexual function and dysfunction studies
- Chromatin Remodeling and Cancer
- Protein Degradation and Inhibitors
- Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Cervical Cancer and HPV Research
- Myasthenia Gravis and Thymoma
- Ferroptosis and cancer prognosis
- Pulmonary Hypertension Research and Treatments
Third Affiliated Hospital of Sun Yat-sen University
2023-2024
Sun Yat-sen University
2023-2024
Union Hospital
2012-2023
Huazhong University of Science and Technology
2007-2023
Wuhan Union Hospital
2018-2023
China Medical University
2001-2022
Liaoning Cancer Hospital & Institute
2018-2022
Dalian University of Technology
2022
Medical College of Wisconsin
2016-2018
Nanjing University
2016
In an effort for early assessment of treatment response, we investigate radiation induced changes in quantitative CT features tumor during the delivery chemoradiation therapy (CRT) pancreatic cancer.Diagnostic-quality data acquired daily routine CT-guided CRT using a CT-on-rails 20 head cancer patients were analyzed. On each CT, head, spinal cord and aorta delineated histograms number (CTN) these contours extracted. Eight histogram-based radiomic metrics including mean CTN (MCTN), peak...
Purpose Understanding complex abdominal organ motion is essential for management in radiation therapy (RT) of tumors. This study investigates induced by respiration and peristalsis, during various time durations relevant to RT, using CT MRI techniques acquired under free breathing (FB) breath hold (BH). Methods A series images with and/or from 37 randomly-selected pancreatic or liver cancer patients were analyzed assess the frames. These data include FB 4DCT 15 (for duration 5 sec), 2D...
Objective To comparatively evaluate the hematological toxicity (HT) associated with 3 concurrent chemoradiotherapies that are routinely used to treat cervical cancer, including 3-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiation therapy (IMRT), and RapidARC establish a new normal tissue complication probability model of bone marrow (BM) predict HT in cancer patients undergoing chemoradiotherapy. Methods Patients (N = 100) who received cisplatin whole-pelvic were...
Background Interferon-α (IFN-α) plays a pivotal role in host antitumor immunity, and the evasion of IFN-α signaling pathway can lead to resistance during treatment cancer. Although interplay between tumor cells has been extensively investigated differentiated cells, much less attention directed tumor-repopulating (TRCs). Methods Three-dimentional soft fibrin matrix was used select grow highly malignant tumorigenic melanoma TRCs. The regulation integrin β3 (ITGB3)-c-SRC-STAT TRCs both vitro...
Abstract The development of castration‐resistant prostate cancer (CRPC) is a significant factor that reduces life expectancy among patients with cancer. Previously, it reported CDK4/6 inhibitors can overcome the resistance CRPC to BET by destabilizing BRD4, suggesting combination and promising approach for treating CRPC. In this study, candidates affect combined antitumor effect on aimed examine. data demonstrates CBX3 abnormally upregulated in inhibitors‐resistant cells. almost positively...
The Like-Smith (LSM) family plays a critical role in the progression of several cancers. However, function LSMs chemoresistance gastric cancer (GC) is still elusive.The Cancer Genome Atlas (TCGA) database, Gene Expression Omnibus (GEO) database and Tumor Immune Estimation Resource Analysis (TIMER) were utilized to analyze expression, prognostic value immune infiltration GC patients. Moreover, qPCR immunohistochemistry (IHC) experiment conducted with clinical samples.The expression was...
Abstract Purpose In this retrospective study, we evaluated the treatment patterns and survival after positron emission tomography-computed tomography (PET/CT)-guided local consolidation therapy (LCT) for oligometastatic non-small cell lung cancer (NSCLC). Methods We reviewed medical records of Chinese patients with stage IV (≤ 5 metastases) who had undergone PET/CT were eligible systemic at two centers between May 2005 August 2019. Propensity score matching (1:1) was used to reduce selection...
Background and AimsHepatic ischemia-reperfusion injury (HIRI) is a prevalent complication of liver transplantation, partial hepatectomy, severe infection, necessitating the development more effective clinical strategies. Receptor activity–modifying protein 1 (RAMP1), member G protein–coupled receptor adapter family, has been implicated in numerous physiological pathological processes. The study aimed to investigate pathogenesis RAMP1 HIRI.
Inflammation-related gene polymorphisms are some of the most important determinants for cancer susceptibility, clinical phenotype diversity, and response to radiotherapy chemotherapy. However, relationship between these head neck squamous cell carcinoma (HNSCC) remains unclear. The aim this study was investigate role inflammation-related in developmental risk sensitivity HNSCC. Matrix-Assisted Laser Desorption Ionization Time Flight (MALDI-TOF) genotyping system used genotype 612 individuals...
// Yingqiu Song 1, 2 , Beth Erickson 1 Xiaojian Chen Guiling Li Gang Wu Eric Paulson Paul Knechtges 3 and X. Allen Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA Cancer Center, Union Hospital, Tongji College, Huazhong University Science Technology, Wuhan, China Radiology, Correspondence to: Li, email: ali@mcw.edu Keywords: cervical cancer; MRI for radiation planning; gross tumor volume delineation; external beam therapy Received: October 11,...
Nonsmall cell lung cancer (NSCLC) mainly contains adenocarcinoma (AC) and squamous carcinoma (SqCC). This study investigated single nucleotide polymorphism (SNP) of topoisomerase II alpha (TOP2A) dual-specificity phosphatase 6 (DUSP6) in a hospital-based case control cohort individuals for association with risk different histological subtypes NSCLC.A total 454 (237 SqCC 217 AC) NSCLC patients, healthy controls were recruited analysis TOP2A rs471692 DUSP6 rs2279574 genotypes using the TaqMan...
Dual-specificity phosphatase 6 (DUSP6) inactivates different target kinases to regulate cell proliferation and differentiation. Altered DUSP6 expressions or gene polymorphisms are associated with human cancer development including non-small lung (NSCLC). DNA topoisomerase II alpha (TOP2A) regulates chromosome condensation chromatid separation, altered TOP2A drug resistance development. This study assessed single nucleotide (SNPs) NSCLC patient survival.This included 152 surgically resected...
Erectile dysfunction (ED) caused by intraoperative nerve injury is a major complication of pelvic surgery. Adipose-derived stem cells (ADSCs) have presented therapeutic potential in rat model bilateral cavernous (BCNI), while inadequate vivo viability has largely limited their application. Nuclear factor-E2-related Factor (Nrf2) key transcription factor that regulates cellular anti-oxidative stress. In this work, we investigated the effect Nrf2 expression regulation on ADSCs, and explore its...
We report a 24-year-old woman presenting with relapsed soy-bean-size tender mass at the junction of soft and hard palate history palatine tumor small cell carcinoma. Reexcision surgery was performed histopathological features were consistent. The patient treated six cycles chemotherapy consisting etoposide cisplatin. After one year, developed bone metastases Cushing's syndrome, successfully recovered subsequent irinotecan cisplatin plus radiotherapy. There no evidence recurrence or...
Background: Chemotherapy resistance is a great challenge in the treatment of gastric cancer (GC), so it urgent to explore prognostic markers chemoresistance. PUF60 (Poly (U)-binding splicing factor 60) nucleic acid-binding protein that has been shown regulate transcription and link tumorigenesis various cancers. However, its biological role function chemotherapy GC unclear. Methods: The expression value chemotherapy-resistant patients were analyzed by databases K-M Plotter. functional effect...
Objective: To investigate clinicopathological features of carcinoma showing thymus-like elements (CASTLE) in the head and neck regions. Methods: Clinicopathological data 7 patients with CASTLE regions were retrospectively reviewed.Immunohistochemical staining situ hybridization for EBER performed. BRAF(V600E) mutation was examined by ARMS method 6 cases. Results: There 5 females 2 males age between 49 78 years (average 65.6 years). All tumors solitary nodular lesions an infiltrative border,...
Purpose: Acute hematologic toxicity associated with bone marrow injury is a common complication of chemoradiation therapy (CRT) for pelvic malignancies. In this work, we investigate the feasibility using quantitative CT to detect during CRT. Methods: Daily CTs were acquired routine CT‐guided radiation CT‐on‐rails 15 cervical cancer patients. All patients treated dose 45.0 50.4 Gy in 1.8 Gy/fraction along chemotherapy. For each patient, contours generated L4, L5 and sacrum on first daily then...
Purpose: In an effort of early assessment treatment response, we investigate radiation induced changes in CT number histogram GTV during the delivery chemoradiation therapy (CRT) for pancreatic cancer. Methods: Diagnostic‐quality data acquired daily routine CT‐guided CRT using a CT‐on‐rails 20 head cancer patients were analyzed. All treated with dose 50.4 28 fractions. On each set, contours and spinal cord delineated. The Hounsfiled Units (HU) these contourswere extracted processed MATLAB....