A5029606260- Heme Oxygenase-1 and Carbon Monoxide
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Alcohol Consumption and Health Effects
- Biosimilars and Bioanalytical Methods
- Cancer therapeutics and mechanisms
- Lung Cancer Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Cancer Treatment and Pharmacology
- Thermal Regulation in Medicine
- Genomics, phytochemicals, and oxidative stress
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Agriculture, Soil, Plant Science
- Flavonoids in Medical Research
- Autophagy in Disease and Therapy
- Neurological and metabolic disorders
- HER2/EGFR in Cancer Research
- Parkinson's Disease Mechanisms and Treatments
- Neonatal and Maternal Infections
University of Cincinnati Medical Center
2024
Qingdao University
2014-2023
Yuhuangding Hospital
2014-2023
First Affiliated Hospital of Bengbu Medical College
2019-2023
Jinan Central Hospital
2023
University of Manchester
2021
University of Plymouth
2021
Greater Manchester Mental Health NHS Foundation Trust
2021
Higher Institute for Qualitative Studies
2021
King's College London
2021
BackgroundPrevious antibiotic exposure is an important risk factor for invasive fungal infection (IFI). Antibiotic overexposure common in lower-income countries; however, multi-centre studies concerning IFI relation to are scarce.AimThis prospective, matched case–control study explored the correlation of and very preterm infants or very-low-birthweight admitted 23 tertiary hospitals China between 2018 2021.MethodsUsing a 1:2 design gestational age, birth weight early-onset sepsis (yes/no),...
Carbon monoxide (CO) poisoning is one of the most important health concerns and may result in neuropathologic changes neurologic sequelae. However, few studies have addressed correlation between CO blood-brain barrier (BBB) impairment. In this study, we investigated effects N-butylphthalide (NBP) on expressions zonula occludens-1 (ZO-1), claudin-5 aquaporin-4 (AQP-4) proteins a rat model. The results indicated that brain water content was obviously increased, tight junctions (TJs)...
Abstract Carbon monoxide ( CO ) poisoning is one of the leading causes toxicity‐related mortality and morbidity worldwide, primarily manifested by acute delayed central nervous system CNS injuries other organ damages. However, its definite pathogenesis poorly understood. The aim this study was to explore ultrastructural functional impairment mitochondria protection sulphoraphane SFP at different dosages on hippocampus neurons in rats after exposure . We found that could induce advanced...
Cognitive impairment is the most common neurologic sequelae after carbon monoxide (CO) poisoning, and previous investigations have demonstrated that N-Butylphthalide (NBP) could exert a broad spectrum of neuroprotective properties. The current study aimed to investigate effect NBP on cognitive dysfunction in rats acute severe CO poisoning. Rats were randomly divided into normal control group, poisoning group CO+NBP group. animal model was established by exposure chamber, then all received...
Oxidative stress has been considered as an important cause of neurocyte damage induced by carbon monoxide (CO) poisoning; however, the precise mechanisms are not fully understood. The study aimed to elucidate molecular mechanism and neuroprotective effect targeted regulatory nuclear factor erythroid2-related 2 (Nrf2) gene on acute brain injury in CO poisoning rats. An rat model was established inhalation hyperbaric oxygen chamber followed administration Nrf2 gene-loaded lentivirus....
Carbon monoxide (CO) poisoning can lead to many serious neurological symptoms. Currently, there are no effective therapies for CO poisoning. In this study, rats exposed received hyperbaric oxygen therapy, and those in the Fasudil group were given additional injection once daily. We found that escape latency (CO group) was significantly prolonged, T1 /Ttotal obviously decreased, mean time active notably extended compared with normal control (NC group, P < 0.05). After administration of...
The aim of the present study was to analyze clinical characteristics visual dysfunction in patients with carbon monoxide (CO) poisoning. A total 436 CO poisoning were enrolled our hospital from October 2012 December 2018, including 193 moderate (MP group), 165 severe (SP and 78 delayed encephalopathy (DE group). analyzed through collection medical history, regular physical examination, brain magnetic resonance imaging (MRI), ophthalmological National Eye Institute Visual Function...
Abstract Sulforaphane (SFN) has attracted much attention due to its ability on antioxidant, anti‐inflammatory, and anti‐apoptotic properties, while functional targets underlying mechanism of action brain injury caused by acute carbon monoxide poisoning (ACOP) have not been fully elucidated. Herein, we used a systematic network pharmacology approach explore the SFN in treatment damage after ACOP. In this study, results demonstrated that there were total 81 effective target genes 36...
Purpose . To investigate the efficacy of XingZhi-YiNao (XZYN) granules and hyperbaric oxygenation (HBO) for cognition motor dysfunction in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). Methods Eighty-nine DEACMP were randomly divided into control group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">19</mml:mn></mml:math>), HBO...
The pathogenesis of brain injury caused by carbon monoxide poisoning (COP) is very complex, and there no exact reliable treatment in clinic. In the present study, we screened therapeutic target related signal pathway Salvia Miltiorrhiza for acute COP injury, clarified pharmacological mechanism multicomponent, multitarget, multisignal network pharmacology. To further verify effect on based results analysis, a total 216 male healthy Sprague Dawley rats were collected study randomly assigned to...
Background: QL1101 is a biosimilar molecule of bevacizumab (BEV,Avastin®) which monoclonal antibody (mAb) that binds and inhibits vascular endothelial growth factor (VEGF). The main purpose the study to evaluate whether effectiveness equivalent Avastin®; secondary estimate safety immunogenicity. Methods: planed recruitment 512 patients with locally metastatic or recurrent non-squamous cell non-small lung cancer (NCT03169335). into (test group) Avastin® (control in combination...
Background/Objectives: Estrogen receptor-α coactivator MED1 is overexpressed in 40–60% of human breast cancers, and its high expression correlates with poor disease-free survival patients undergoing anti-estrogen therapy. However, the molecular mechanism underlying upregulation activation cancer treatment resistance remains elusive. Methods: miRNA mRNA analysis was performed using NCBI GEO database. targeting impact on therapy evaluated control tamoxifen-resistant cell lines by miR-205...
Objective To explore the neuroprotective effect of targeted regulation Nrf2 gene on rats with brain injury caused by acute severe carbon monoxide (CO) poisoning. Methods A total 180 healthy adult SD were divided into 4 groups at random: normal control group(NC group), CO poisoning group(CO lentivirus group(LV group) and therapy group(Nrf2 45 in each group. An toxic rat model was established inhalation a hyperbaric oxygen tank. The group directly injected dilution (4×106 TU/μl)...
Objective To investigate the expressions of neurite outgrowth inhibitor (Nogo), myelin-associated glycoprotein (MAG) and Nogo receptor-1 (NgR1), neuro-protective effect N-Butylphthalide (NBP) in rat brain tissues following acute CO poisoning. Methods Sixty Sprague-Dawley rats were randomly divided into normal group, poisoning group NBP treatment (n=20). Rats induced hyperbaric chamber received oxygen therapy. Meanwhile, subjected to oral 6 mg/100 g twice a day additionally. The Nogo,...
To investigate the molecular mechanism by which α-synuclein (α-Syn) regulates interferon regulatory factor 1 (IRF-1) expression.SH-SY5Y cells overexpressing α-Syn and transgenic mouse model carrying human gene with A53T mutation (3 6 months old) were examined for IRF-1 mRNA protein expressions using real-time PCR Western blotting, respectively. The subcellular localization of was determined immunofluorescence staining cytoplasmic/nuclear isolation. optimal concentrations proteasome inhibitor...