A5038714865- Protist diversity and phylogeny
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Advanced Battery Technologies Research
- Soybean genetics and cultivation
- Chromosomal and Genetic Variations
- Electric Vehicles and Infrastructure
- Electric and Hybrid Vehicle Technologies
- Essential Oils and Antimicrobial Activity
- Toxin Mechanisms and Immunotoxins
- Fish Biology and Ecology Studies
- Phytase and its Applications
- Ion Channels and Receptors
- Cervical Cancer and HPV Research
- Calcium signaling and nucleotide metabolism
- Phytochemistry and Bioactive Compounds
- Legume Nitrogen Fixing Symbiosis
- Bacteriophages and microbial interactions
- Nicotinic Acetylcholine Receptors Study
- Supercapacitor Materials and Fabrication
- Medicinal Plants and Neuroprotection
- Multicomponent Synthesis of Heterocycles
- Cholinesterase and Neurodegenerative Diseases
- Rice Cultivation and Yield Improvement
- Aquaculture Nutrition and Growth
Lupin Pharmaceuticals (India)
2009-2024
Harvard University
2024
Netaji Subhas University of Technology
2023-2024
Max Planck Institute for Biology
2021-2024
University of Lucknow
2020
Mewar University
2018
Jamia Hamdard
2018
Indian Institute of Technology Bombay
2016
University of Mumbai
2016
We have amplified DNA from <italic>Mycobacterium tuberculosis</italic> on a paper substrate in 10 minutes using helicase dependent amplification technique.
During their development following sexual conjugation, ciliates excise numerous internal eliminated sequences (IESs) from a copy of the germline genome to produce functional somatic genome. Most IESs are thought have originated transposons, but presumed homology is often obscured by sequence decay. To obtain more representative perspectives on nature and ciliate editing, we assembled 40,000 Blepharisma stoltei, species belonging lineage (Heterotrichea) that diverged early those intensively...
The discovery of a series thiophenephenylsulfonamides as positive allosteric modulators (PAM) α7 nicotinic acetylcholine receptor (α7 nAChR) is described. Optimization this led to identification compound 28, novel PAM nAChR). Compound 28 showed good in vitro potency, with pharmacokinetic profile across species excellent brain penetration and residence time. robustly reversed the cognitive deficits episodic/working memory both time-delay scopolamine-induced amnesia paradigms object social...
Massive DNA excision occurs regularly in ciliates, ubiquitous microbial eukaryotes with somatic and germline nuclei the same cell. Tens of thousands internally eliminated sequences (IESs) scattered throughout ciliate genome are deleted during development streamlined genome. The genus Blepharisma represents one two high-level clades (subphylum Postciliodesmatophora) and, unusually, has dual pathways nuclear development. This makes it ideal for investigating functioning evolution these...
PI3Kδ inhibitors have been approved for B-cell malignancies like CLL, small lymphocytic lymphoma, and so forth. However, currently available are nonoptimal, showing weakness against at least one of the several important properties: potency, isoform selectivity, and/or pharmacokinetic profile. To come up with a inhibitor that overcomes all these deficiencies, pharmacophoric expansion strategy was employed. Herein, we describe systematic transformation "three-blade propeller" shaped lead,...
Voltage-gated sodium channel NaV1.7 is a genetically validated target for pain. Identification of inhibitors with all the desired properties to develop as an oral therapeutic pain has been major challenge. Herein, we report systematic structure-activity relationship (SAR) studies carried out identify novel sulfonamide derivatives potent, selective, and state-dependent Scaffold hopping from benzoxazine chroman indane bicyclic system followed by thiazole replacement on led identification lead...
Ciliates are a widespread clade of microbial eukaryotes with the greatest diversity nuclear genetic codes (at least eight) following recent addition 1 . All non-standard ciliate involve stop codon reassignments 1,2,3 Two these ambiguous 1–3 , “stop” codons either translated or terminating translation depending on their context 2,3 Ambiguous have arisen not only in ciliates, but also independently trypanosomatids from genus Blastocrithidia 4 and an alveolate species Amoebophrya 5 ciliates...
The identification of a novel class potent pan-genotypic NS5A inhibitors with good pharmacokinetic profile suitable for potential use in treating HCV infections is disclosed here. present series compounds are less complex tricyclic central core, identified through systematic SAR study carried out on biphenyl moiety. outcome has confirmed the requirement near planar and linear conformation molecule to achieve best activity. In addition, substituted imidazoles improvement antiviral activity...
The role of calcium release-activated (CRAC) channels is well characterized and particular importance in T-cell function. CRAC are involved the pathogenesis several autoimmune diseases, making it an attractive therapeutic target for treating inflammatory like rheumatoid arthritis (RA). A systematic structure-activity relationship study with goal optimizing lipophilicity successfully yielded two lead compounds, 36 37. Both compounds showed decent potency selectivity a remarkable...
Ciliates are a widespread clade of microbial eukaryotes with the greatest diversity nuclear genetic codes (at least eight) following recent addition 1 . All non-standard ciliate involve stop codon reassignments 1,2,3 Two these ambiguous 1–3 , “stop” codons either translated or terminating translation depending on their context 2,3 Ambiguous have arisen not only in ciliates, but also independently trypanosomatids from genus Blastocrithidia 4 and an alveolate species Amoebophrya 5 ciliates...
ABSTRACT This work deals with the design and development of a dual source based propulsion architecture for electric vehicles. The converter utilized system is derived from conventional CuK converter, which operates in bidirectional power flow mode. proposed has two energy sources: battery supercapacitor (SC). continuous input output currents at low high voltage sides, improves cycle life hybrid storage (SC battery) DC‐link capacitor. Further, magnetic reduction compared to two‐input...
A visual summary of our study, merging herbal knowledge with nanotechnology to combat antibiotic resistance. Silver nanoparticles from Zanthoxylum armatum DC. show effective bactericidal activity and enhance efficacy.
Abstract Ciliates are a widespread clade of microbial eukaryotes with the greatest diversity nuclear genetic codes (at least eight) following recent addition 1 . All non-standard ciliate involve stop codon reassignments 1,2,3 Two these ambiguous 1–3 , “stop” codons either translated or terminating translation depending on their context 2,3 Ambiguous have arisen not only in ciliates, but also independently trypanosomatids from genus Blastocrithidia 4 and an alveolate species Amoebophrya 5...
Summary Massive DNA excision occurs regularly in ciliates, ubiquitous microbial eukaryotes with somatic and germline nuclei the same cell. Tens of thousands internally eliminated sequences (IESs) scattered throughout a copy ciliate genome are deleted during development streamlined genome. Blepharisma represents one two earliest diverging classes, and, unusually, has dual pathways nuclear development, making it ideal for investigating functioning evolution these processes. Here, we report...