A5062175850- Chemical Synthesis and Reactions
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Asymmetric Hydrogenation and Catalysis
- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Cancer therapeutics and mechanisms
- Chemical Synthesis and Analysis
- Tuberculosis Research and Epidemiology
- Oxidative Organic Chemistry Reactions
- Vanadium and Halogenation Chemistry
- Sesquiterpenes and Asteraceae Studies
- PI3K/AKT/mTOR signaling in cancer
- Fluorine in Organic Chemistry
- Escherichia coli research studies
- Biochemical and Structural Characterization
- Sulfur-Based Synthesis Techniques
- Cancer Treatment and Pharmacology
- Plant-based Medicinal Research
- Plant Toxicity and Pharmacological Properties
- Carbon dioxide utilization in catalysis
- Synthesis of heterocyclic compounds
- Zeolite Catalysis and Synthesis
- Pneumocystis jirovecii pneumonia detection and treatment
- Cell death mechanisms and regulation
Lupin Pharmaceuticals (India)
2022-2024
University of Cambridge
2019
AstraZeneca (India)
2013
AstraZeneca (United Kingdom)
2013
University of Cincinnati
2007-2008
Los Alamos National Laboratory
2008
National Chemical Laboratory
2002-2005
Swami Ramanand Teerth Marathwada University
1998-1999
We report 1,4-azaindoles as a new inhibitor class that kills Mycobacterium tuberculosis in vitro and demonstrates efficacy mouse models. The series emerged from scaffold morphing efforts was demonstrated to noncovalently inhibit decaprenylphosphoryl-β-D-ribose2'-epimerase (DprE1). With "drug-like" properties no expectation of pre-existing resistance the clinic, this chemical has potential be developed therapy for drug-sensitive drug-resistant tuberculosis.
The cell sensitivity of recombinant human alpha interferons (rIFN-α)of > 95% purity (A,D and the hybrid A/D) crude nature (B F) was studied in (WISH, HeLa, AG1732), bovine (MDBK, BT), monkey (Vero), mouse (L), rabbit (RK-13), hamster (BHK-21) cells. Based on an activity 100% WISH cells, other cells responded to rIFN-αA as follows: AG1732 (90%), HeLa (94%), MDBK BT (170–190%). Rabbit, mouse, had a relative < 1%. rIFN-αB F were essentially equivalent terms sensitivity, but about 20 times more...
We report the modular synthesis of robust, biotinylated biantennary sialylglycoconjugates and their ability to differentiate between two type A influenza strains. This is first demonstration glycoconjugate-based discriminatory capture detection strains intact virus, in presence innate enzymatic activity viral neuraminidases. also demonstrate a "carboassay" using glycoconjugates as reporter elements, which therefore, does not require antibodies. The viruses potential benefit for clinical diagnostics.
Choose your poison: Shiga toxins 1 and 2 are the major virulence factors of E. coli O157:H7. However, is more potent than 1. Biotinylated glycoconjugates have been developed that differentiate between these structurally homologous (see picture; R=OH: selective for 1; R=NHAc: 2). These synthetic materials efficiently capture without interference from sample matrix.
Abstract Glycans cover the surface of all mammalian cells. Several toxins and pathogens use these glycans to bind infect cell. Using a versatile modular synthetic strategy, we have developed biotinylated bi‐ tetraantennary glycoconjugates capture detect E. coli compared capturing ability molecules commercial polyclonal antibodies. Magnetic beads were coated with glycoconjugate or antibody, used capture, isolate, quantify bacterial recovery by using luminescence assay. The...
Pancreatic Ductal Adenocarcinoma (PDAC) remains one of the most difficult to treat cancers. Gemcitabine is still standard care treatment for PDAC but with modest survival benefit and well reported resistance. Here we explored potential inhibiting p21 activated kinase 4 (PAK4), a downstream protein KRAS oncogenic pathway, in combination cells. PAK4 inhibition by KPT-9274 led significant potentiation activity cells, an increase apoptosis, DNA damage cell cycle arrest. At molecular level, dose...
Non-small cell lung cancer (NSCLC) is one of the deadliest types with poor prognosis, accounting for 85% all cases. The phosphoinositide 3-kinase (PI3K) signaling pathway most frequently altered in NSCLC; nonetheless, targeting this yields limited success primarily because drug-induced resistance. PI3K-independent activation serum and glucocorticoid-induced kinase 1 (SGK1) responsible development resistance to PI3K/AKT inhibitors breast cancer. present study investigated potential inhibiting...
A facile regioselective decomposition of tosylhydrazones using NaOH as a base in refluxing isopropyl alcohol is described. This finding has been successfully applied towards the synthesis (±)-α-lipoic acid (1).
Zucker gegen Gifte: Die Shiga-Toxine 1 und 2 sind die wichtigsten Giftstoffe von E. coli O157:H7, wobei Shiga wirksamer ist als 1. Biotinylierte Glycokonjugate können zwischen den strukturhomologen Toxinen unterscheiden (siehe Formel; R = OH: Shiga-1-selektiv; NHAc: Shiga-2-selektiv). Diese synthetischen Substanzen fangen Toxine effizient ohne Störung durch Probenmatrix ein. Supporting information for this article is available on the WWW under...
Direct ammoxidation of propane to acrylonitrile has been investigated recently as an alternate method for the current process based on propene. The Mo−V−Te−Nb−O mixed oxide is most promising catalyst at present this reaction. reaction mechanism over still not experimentally. In work, we have tested presence C6 intermediates during course using 13C-labeled propane. results show that a direct pathway without skeletal rearrangement carbon backbone operates under realistic, steady-state conditions.
Abstract Carbonyl compounds were regenerated from corresponding dithioacetals via refluxing with FeCl3/KI and methanol as a solvent. Keywords: FeCl3 KIDithioacetals Acknowledgment The authors PBS, RRK KP thank CSIR, New Delhi for financial support. Funding under YSA (SPC) scheme is gratefully acknowledged.
Abstract A simple, concise, and stereocontrolled synthesis of (8E,10Z)‐pentadecadien‐1‐ol acetate involving a Cadiot–Chodkiewicz reaction as the key step is described.
CoaBC, part of the vital coenzyme A biosynthetic pathway in bacteria, has recently been validated as a promising antimicrobial target. In this work, we employed native ion mobility-mass spectrometry to gain structural insights into phosphopantothenoylcysteine synthetase domain E. coli CoaBC. Moreover, mass was screening tool identify novel inhibitors enzyme, highlighting utility and versatility technique both for biology drug discovery.