A5007472894- Biochemical and Molecular Research
- Enzyme Structure and Function
- Tuberculosis Research and Epidemiology
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Bacterial Genetics and Biotechnology
- Carbohydrate Chemistry and Synthesis
- Crystallization and Solubility Studies
- Cancer therapeutics and mechanisms
- X-ray Diffraction in Crystallography
- Conducting polymers and applications
- DNA and Nucleic Acid Chemistry
- Colorectal Cancer Treatments and Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Carbon and Quantum Dots Applications
- Antimicrobial Resistance in Staphylococcus
- Cancer-related Molecular Pathways
- Advanced Sensor and Energy Harvesting Materials
- Nanocluster Synthesis and Applications
- DNA Repair Mechanisms
- Lysosomal Storage Disorders Research
- RNA and protein synthesis mechanisms
- HIV/AIDS drug development and treatment
- Enzyme function and inhibition
- Crystallography and molecular interactions
Indian Institute of Technology Kharagpur
2016-2025
National Institute of Research on Jute and Allied Fibre Technology
2025
Jadavpur University
1990-2025
Indian Navy
2024
INHS Asvini
2022-2024
Shree Krishna Hospital
2021-2024
Babasaheb Bhimrao Ambedkar Bihar University
2023-2024
Institute of Medical Sciences
2024
Indian Institute of Science Education and Research Kolkata
2023
National Institute of Technology Durgapur
2015-2023
Abstract Non–small cell lung cancers (NSCLCs) bearing mutations in the tyrosine kinase domain (TKD) of epidermal growth factor receptor (EGFR) often exhibit dramatic sensitivity to EGFR inhibitors gefitinib and erlotinib. Ionizing radiation (IR) is frequently used treatment NSCLC, but little known how tumor–acquired affect responses IR. Because this great clinical importance, we investigated found that clonogenic survival mutant NSCLCs response IR was reduced 500- 1,000-fold compared with...
Abstract The epidermal growth factor receptor (EGFR) is an important determinant of radioresponse, whose elevated expression and activity frequently correlates with radioresistance in several cancers, including non–small cell lung carcinoma (NSCLC). We reported recently that NSCLC lines harboring somatic, activating mutations the tyrosine kinase domain (TKD) EGFR exhibit significant delays repair DNA double-strand breaks (DSB) poor clonogenic survival response to radiation. Here, we explore...
The emerging popularity and wide acceptance of green chemistry environmentally benign/ecofriendly approaches have comprehensively considered for catalyst synthesis methods. Natural resource derived carbogenic quantum dots has been used in assistance with ultrasonic shock wave to graphene oxide (GO) aqueous dispersion order prepare reduced decorated silver nanoparticles following the 'top-down' method. total reduction process is done without using any toxic external reducing agents...
Fluorescent carbon dots, zero-dimensional nanomaterials with surface ligands, have been studied extensively over the past few years in biolabelling or fluorescence-based live cell assays. In past, synthetic organic dyes used as tracking materials, but they severe limitations; fluorescent dots may pave way to and imaging. this work, green synthesized from a source, gram, without any sort of covalent ionic modifications. These gram-derived are unique respect commercial cell-tracking non-toxic,...
Respiratory infections by RNA viruses are one of the major burdens on global health and economy. Viruses like influenza or coronaviruses can be transmitted through respiratory droplets contaminated surfaces. An effective antiviral coating decrease viability virus particles in our surroundings significantly, hence reducing their transmission rate. Here, we have screened a series nanoparticles composites for activity using nanoluciferase-based highly sensitive A reporter virus. We identified...
The hydrothermal synthesis of κ-carrageenan and lemon juice derived carbon dots their application in a fluorescence sensor for Cr(<sc>vi</sc>) ascorbic acid are demonstrated.
Abstract Multifunctional polymer/graphene based lightweight and flexible nanocomposite films are increasingly being utilized in the packaging, electronics, pharmaceutical industries together. Herein, two graphene derivatives: silver nanoparticle decorated reduced oxide (G‐Ag) chemically (rGO) prepared by wet chemical method nanoplatelets (GNP) have been incorporated into linear low density polyethylene (LLDPE) thermoplastic matrix via melt compounding method. The incorporation of derivatives...
Mutations in palmitoyl-protein thioesterase 1 (PPT1), a lysosomal enzyme that removes fatty acyl groups from cysteine residues modified proteins, cause the fatal inherited neurodegenerative disorder infantile neuronal ceroid lipofuscinosis. The accumulation of undigested substrates leads to formation storage bodies are associated with clinical symptoms. Less severe forms PPT1 deficiency have been found recently caused by distinct set mutations, some which retain small amount activity. We...
Protein phosphatase-1 (PP1) plays a key role in dephosphorylation numerous biological processes such as glycogen metabolism, cell cycle regulation, smooth muscle contraction, and protein synthesis. Microorganisms produce variety of inhibitors PP1, which include the microcystin class okadaic acid, latter being major cause diarrhetic shellfish poisoning powerful tumor promoter. We have determined crystal structure molecular complex acid bound to PP1 resolution 1.9 Å. This reveals that binds...
Mutations in a newly described lysosomal enzyme, palmitoyl-protein thioesterase (PPT), were recently shown to be responsible for an autosomal recessive neurological disorder prevalent Finland, infantile neuronal ceroid lipofuscinosis. The disease results blindness, motor and cognitive deterioration, seizures. Characteristic inclusion bodies (granular osmiophilic deposits [GROD]) are found the brain other tissues. vast majority of Finnish cases homozygous missense mutation (R122W) that...