A5047606116- Pregnancy and preeclampsia studies
- Dental Radiography and Imaging
- Agricultural Science and Fertilization
- Bone health and osteoporosis research
- Tuberculosis Research and Epidemiology
- Malaria Research and Control
- Microbial Metabolites in Food Biotechnology
- Genetics and Neurodevelopmental Disorders
- Body Image and Dysmorphia Studies
- Dental Implant Techniques and Outcomes
- Rice Cultivation and Yield Improvement
- Toxin Mechanisms and Immunotoxins
- Drug Transport and Resistance Mechanisms
- Autism Spectrum Disorder Research
- Hip and Femur Fractures
- RNA Interference and Gene Delivery
- Trauma and Emergency Care Studies
- Eating Disorders and Behaviors
- Orthodontics and Dentofacial Orthopedics
- Reproductive System and Pregnancy
- Plant Toxicity and Pharmacological Properties
- Sesquiterpenes and Asteraceae Studies
- Sexual function and dysfunction studies
- Freezing and Crystallization Processes
- Moringa oleifera research and applications
Government Medical College and Hospital
2025
Indian Agricultural Research Institute
2024
Teerthanker Mahaveer University
2023
Johns Hopkins Medicine
2022-2023
Johns Hopkins University
2022-2023
Banaras Hindu University
2023
Holy Family Hospital
2023
Central Drug Research Institute
1997-2022
Council of Scientific and Industrial Research
2019-2022
Yale University
2020-2021
Endosomal escape is a key step for intracellular drug delivery of nucleic acids, but reliable and sensitive methods its quantitation remain an unmet need. In order to rationally optimize the mRNA transfection efficiency library polymeric materials, we designed deactivated Renilla luciferase-derived molecular probe whose activity can be restored only in cytosol. This coencapsulated with same vehicle, thereby accurately measuring endosomal efficiency. We examined poly(amine-co-ester) (PACE)...
Due to the recent rapid expansion of scooter sharing companies, there has been a dramatic increase in number electric (e-scooter) injuries. Our purpose was conduct systematic review characterize demographic characteristics, most common injuries, and management patients injured from scooters.We searched PubMed, EMBASE, Scopus, Web Science databases using variations term "electric scooter". We excluded studies conducted prior 2015, with population less than 50, case reports, not focused on...
Background: Severe early-onset fetal growth restriction can lead to a range of adverse outcomes including or neonatal death, neurodisability, and lifelong risks the health affected child. Sildenafil, phosphodiesterase type 5 inhibitor, potentiates actions nitric oxide, which leads vasodilatation uterine vessels might improve in utero. The objective is evaluate effectiveness safety Sildenafil citrate for treatment Doppler velocimetry uterine, umbilical artery systolic/diastolic ratio (S/D...
Abstract Context: Eating distress syndrome (EDS) is characterized by distressing and conflicting thoughts about the body shape eating behaviors accompanied self-imposition of strict dietary and/or exercise regimes in absence any significant weight loss. EDS has a prevalence nearly 11% associated with psychological distress, internalizing externalizing problems, lesser well-being, reduced quality life. Aims: The study aimed to assess relationship between eating-related messages image...
Kidney Disease Improving Global Outcomes (KDIGO) 2017 Clinical Practice Guideline has recommended treatment decisions for patients with chronic kidney disease (CKD) osteoporosis and/or high risk of fracture. Bisphosphonates, the first-line anti-osteoporosis drugs have concern worsening functions. Moreover, despite impaired bone formation in CKD patients, teriparatide, formation-stimulating drug is not recommended. Thus, there an urgent need safe and effective patients. Here, rats, we tested...
In preclinical studies, fructooligosaccharide (FOS) showed beneficial skeletal effects but its effect on peak bone mass (PBM) and loss caused by estrogen (E2) deficiency has not been studied, we set out to study these in rats. Short-chain (sc)-FOS had no body weight, composition, energy metabolism of ovary intact (sham) ovariectomized (OVX) scFOS did affect serum urinary calcium phosphorus levels, absorption, although an increasing trend was noted the sham group. Sham OVX rats given better...
Purified serum amyloid P component (SAP), the major acute-phase reactant of mice, augmented in vitro listericidal activity inflammatory (elicited) macrophages, bone marrow-derived monocytes, and macrophages from a subcutaneous site inflammation. Monocytes C57BL/B6 which are relatively resistant to Listeria monocytogenes, exhibited significantly greater enhanced killing capacity for listeria than listeria-susceptible A/J mice. SAP did not alter extent phagocytosis by opsonized L. nor was...
A combination of diosmin and hesperidin (9:1 ratio) is marketed as a dietary supplement/nutraceutical for cardiovascular health. We studied the skeletal effect this (90% 10% hesperidin, henceforth named DH). showed that a) in rats with femur osteotomy, DH stimulated callus bone regeneration, b) growing rats, promoted peak mass achievement c) OVX rendered osteopenic, completely restored trabecular bones strength along increases surface referent formation serum osteogenic marker. Furthermore,...
Mycobacterium leprae infection causes bone lesions and osteoporosis, however, the effect of antileprosy drugs on is unknown. We, therefore, set out to address it by investigating osteogenic differentiation from marrow (BM)-derived mesenchymal stem cells (MSCs). Out 7 drugs, only clofazimine (CFZ) reduced MSCs viability (IC50 ∼ 1 μM) their but increased adipogenic a par with rosiglitazone, this was blocked peroxisome proliferator-activated receptor gamma antagonist, GW9662. CFZ also decreased...
Societal changes that occurred during the COVID-19 pandemic may have altered epidemiology of ankle fractures. The aim this study was to assess trends in emergency department visits for fractures from 2019 2020 United States.The National Electronic Injury Surveillance System (NEISS) database is a sample hospitals States stratified and weighted based on (ED) size, which used generate national estimates (NEs). NEISS queried patients who sustained an fracture. Patients before (BC) (July...
Abstract The effect of purified mouse serum amyloid P‐component (SAP) treatment alveolar macrophages (AMs) on their uptake Mycobacterium tuberculosis Erdman was investigated, in vitro . SAP (0.5–50.0 µg/ml), a concentration‐dependent manner, inhibited the M. by AMs; maximum inhibition (33.43%) occurred at 10.0 µg/ml. could be observed as early 30 min after incubation AMs with µg/ml SAP; however, an 60 induced beyond which response became static. SAP‐mediated decreased also resulted reduced...
Introduction Racial and ethnic disparities remain a major problem in orthopedic surgery, driving inequitable resource distribution, disparate clinical outcomes, increased healthcare costs. The objective of this study was to investigate potential racial/ethnic the incidence injury patterns lower extremity trauma (LET) United States over past 10 years, as well differences final disposition outcomes. Materials Methods National Electronic Injury Surveillance System database queried for all LET...
Soil health degradation is a major threat in agricultural sustainability specially under rainfed agriculture. The purpose of this study was to assess the impact long-term fertilization and manuring on soil organic carbon, nutrient status, uptake yield trends rice (Oryza sativa L.)-lentil (Lens culinaris L.) cropping system situated at Agriculture Research Farm Banaras Hindu University, Varanasi, Uttar Pradesh. samples were collected 2019 2021 after harvesting rainy (kharif) season from 34...
Background: Pregnancy and childbirth is universally celebrated as an event. It can also be one of experiences misery suffering when complications or adverse circumstances comprise the pregnancy, causing morbidity even mortality. To study second trimester placental localization a predictor pregnancy outcome.Methods: The was conducted in Upper India Sugar Exchange Maternity Hospital, GSVM Medical College, Kanpur, from January 2014 to July 2015 on 592 pregnant women between 18-24 week over...
Background: The objective of study was to the effect isoflavone supplement on bone density postmenopausal women. Methods: Women aged 49–65 y (n = 205) were enrolled in a double-blind, prospective randomized, placebo-controlled trial; 177 completed trial. Bone density, body composition, turnover markers and diet measured at baseline after 12 months. Results: Loss lumbar spine mineral content significantly lower women taking than those placebo. Interactions between treatment group menopausal...
Background: Hypertension is one of the commonest medical complications during pregnancy and a leading cause maternal perinatal mortality. The objective this study was to evaluate efficacy color Doppler in predicting induced hypertension at early gestation by assessing blood flow velocity profile assess role antioxidants reducing oxidative stress disease their effect on outcome. Methods: carried as blind prospective 310 antenatal patients attending outpatient department indoor cases upper...
Introduction: The problems associated with age-related skeletal osteopenia have received attention since the human skeleton undergoes a continuous physiologic decrease in bone mass advancing age. Bone status at various sites can be assessed using dual-energy X-ray absorptiometry (DXA) or quantitative computed tomography. It would useful to answer whether radiographic changes mandible indicate osteopenia. Aims and Objectives: aim objective of study was examine mandibular cortical index (MCI)...
Amending a problem soil in addition to nutrient input is crucial for maintaining healthy and productive the long run. The study aimed at evaluating long-term impact of manuring fertilization with or without liming on different attributes crop yield an acidic Alfisol. Surface samples (0–15 cm) were collected from selected 7 treatments, viz. Control; N; FYM; ½(N+FYM)+PX/2+KY/2; NPK; NPK+L; P(A-X)K(B-Y)+FYM+L Permanent Manurial Trial (PMT) Birsa Agricultural University, Ranchi, after harvesting...