A5009588266- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Heat shock proteins research
- Physiological and biochemical adaptations
- Animal Behavior and Reproduction
- Medicinal Plants and Neuroprotection
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- Insect and Pesticide Research
- Oral microbiology and periodontitis research
- Insect Utilization and Effects
- Hearing, Cochlea, Tinnitus, Genetics
- Phytochemicals and Medicinal Plants
- Zebrafish Biomedical Research Applications
- Genomics and Phylogenetic Studies
- Nuclear Receptors and Signaling
- Complementary and Alternative Medicine Studies
- Conservation, Ecology, Wildlife Education
- Medicinal Plants and Bioactive Compounds
- Biofuel production and bioconversion
- Arsenic contamination and mitigation
- Ion Channels and Receptors
- RNA and protein synthesis mechanisms
- Diverse Interdisciplinary Research Innovations
- Dendrimers and Hyperbranched Polymers
Central Drug Research Institute
2017-2020
Institute of Genomics and Integrative Biology
2020
Indian Institute of Science Education and Research Kolkata
2015-2018
The University of Texas at Austin
2010-2013
Cold Spring Harbor Laboratory
2012-2013
Addiction Research Foundation
2013
National Centre for Biological Sciences
2009
Microbial media has undergone several changes since its inception but some key challenges remain. In recent years, there been exploration of alternative nutrient sources, both to cater the specificity in requirement growth "fussy microorganisms" and also reduce costs for large-scale fermentation that is required biotechnology. Our mini-review explores these developments points at lacunas present areas exploration, such as a lack concerted effort pH osmolarity regulation. We hope our...
In sensory circuits of the brain, developmental changes in expression and modulation voltage-gated ion channels are a common occurrence, but such often difficult to assign clear functional roles. We have explored this issue binaural neurons medial superior olive (MSO), whose temporal precision detecting coincidence inputs dictates resolution azimuthal sound localization. show that MSO principal gerbils during first week hearing, hyperpolarization-activated current (I(h)) progressively...
Oxidative damage caused by free radicals plays an important role in the causation and progression of many diseases, including aging. Free-radical is countered mechanisms, both active antioxidant enzymatic activity our body passive antioxidants. Antioxidant response can accommodate increased oxidative diseased states to a level but beyond that level, additional antioxidants are required combat stress. Apart from regular dietary sources antioxidants, traditional herbal medicines demonstrate...
Parkinson's disease remains as one of the most common debilitating neurodegenerative disorders. With hopes finding agents that can cure or reduce pace progression disease, we studied two traditional medicinal plants: Centella asiatica and Withania somnifera have been explored in some recent studies. In agreement with previous work on ethanol extracts these plants mice model, saw an improvement oxidative stress profile well behavioral performance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine...
Drosophila melanogaster has proven to be a useful model system for the genetic analysis of ethanol-associated behaviors. However, past studies have focused on response adult fly large, and often sedating, doses ethanol. The pharmacological effects low moderate quantities ethanol remained understudied. In this study, we tested acute (∼7 mM internal concentration) larvae. While did not affect locomotion or an odorant, observed that impaired associative olfactory learning when heat shock...
Drosophila melanogaster larvae are model systems for studies of development, synaptic transmission, sensory physiology, locomotion, drug discovery, and learning memory. A detailed behavioral understanding can advance all these fields neuroscience. Automated tracking expand fine-grained analysis, yet its full potential remains to be implemented the larvae. All published methods unable track near high contrast objects, including petri-dish edges encountered in many paradigms. To alleviate...
With increasing use of various techniques to record optically and electrophysiologically from awake behaving animals the growing developments brain-machine interfaces, one might wonder if acute-slice physiology is on its deathbed. Have we actually arrived at a stage where can abandon acute slices, with most information about brain functions coming in vivo experiments? We do not believe that this case, given our understanding nuts bolts nervous system, such as ion channels transporters...
In this study, a fluorophore can be easily localized inside animal cell line H9c2 using novel N-TER™ based strategy, and the internalized acts both as fluorescent dye an antioxidant.
Alcohol addiction is a disease that includes diverse set of phenotypes. Functional alcohol tolerance an adaptation to the effects restores neuronal homeostatic balance while drug present. When suddenly withheld, these adaptations unbalance nervous system and are thought be origin some withdrawal symptoms. Withdrawal symptoms, which can motivating factor for alcoholics relapse, taken as evidence physiological ethanol dependence. Both symptoms diagnostic criteria alcoholism. Recent studies...
Many insects, including Drosophila melanogaster, have a rich repertoire of olfactory behavior.Combination robust behavioral assays, physiological and molecular tools render D. melanogaster as highly suitable system for studies.The small number neurons in the fruit flies, especially sensory larval stage, makes exploration coding at all stages its nervous potentially tractable goal, which is not possible foreseeable future any mammalian preparation.Advances recordings, signaling detailed...
Time series tools are part and parcel of modern day research. Their usage in the biomedical field; specifically, neuroscience, has not been previously quantified. A quantification trends can tell about lacunae current uses point towards future uses. We evaluated principles applications few classical time tools, such as Principal Component Analysis, Neural Networks, common Auto-regression Models, Markov Hidden Fourier Spectral addition to diverse work, generically lumped under category....
Hyperpolarization-activated, cyclic nucleotide-sensitive, cation non-selective (HCN) channels are gaining attention in recent years.These ion-channels gated by two factors: voltage, specifically hyperpolarization and some subunits, more than others, nucleotides.They conduct both sodium potassium ions, regulate many functions neuronal non-neuronal cells.In neurons, HCN channel range from setting resting potential, synaptic normalization, gain control, after-hyperpolarization, responses...