A5022136943- Alzheimer's disease research and treatments
- Renin-Angiotensin System Studies
- Nuclear Receptors and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Adenosine and Purinergic Signaling
- Receptor Mechanisms and Signaling
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Anesthesia and Neurotoxicity Research
- Histone Deacetylase Inhibitors Research
- Nerve injury and regeneration
- Natural product bioactivities and synthesis
- Supramolecular Self-Assembly in Materials
- Insect and Pesticide Research
- Schizophrenia research and treatment
- Cancer-related cognitive impairment studies
- Apelin-related biomedical research
- Prenatal Substance Exposure Effects
- Family Caregiving in Mental Illness
- Drug Solubulity and Delivery Systems
- Pesticide Exposure and Toxicity
- Mesenchymal stem cell research
- Botulinum Toxin and Related Neurological Disorders
- Advanced Drug Delivery Systems
Central Drug Research Institute
2012-2024
Academy of Scientific and Innovative Research
2015-2024
Indian Institute of Toxicology Research
2003
Traditionally, the term Parkinsonism in Parkinson's disease (PD) is characterized by its paradigmatic features that comprise of motor abnormalities. Due to lack awareness about non-motor abnormalities PD, this category received little attention date and it seems a long way when would be also categorized PD. Recently, PD are considered as "the dark horse" may lead progression un-revertible symptoms disease. Here, review, we have provided an overview various symptoms, their consequence...
Copious experimental and postmortem studies have shown that oxidative stress mediated degeneration of nigrostriatal dopaminergic neurons underlies Parkinson’s disease (PD) pathology. CNB-001, a novel pyrazole derivative curcumin, has recently been reported to possess various neuroprotective properties. This study was designed investigate the mechanism CNB-001 in subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) rodent model PD. Administration MPTP (30 mg/kg for four consecutive...
Caffeine possesses potent antioxidant, anti-inflammatory and anti-apoptotic activities against a variety of neurodegenerative diseases, including Alzheimer's disease (AD) Parkinson's (PD). The goal this study was to investigate the protective role psychoactive substance like caffeine on hippocampal neurogenesis memory functions in streptozotocin (STZ)-induced neurodegeneration rats.Caffeine is natural CNS stimulant, belonging methylxanthine class, widely consumed substance. It reported abate...
Abstract Pyrethroid‐based mosquito repellents (MR) are commonly used to protect humans against vector. New born babies and children often exposed pyrethroids for long periods by the use of liquid vaporizers. Occupational experimental studies indicate that can cause clinical, biochemical neurological changes, exposure during organogenesis early developmental period is especially harmful. The neurotoxicity caused MR has aroused concern among public regarding their use. In present study, effect...
Dopaminergic neurotransmission has been investigated extensively, yet direct optical probing of dopamine not possible in live cells. Here we image intracellular with sub-micrometer three-dimensional resolution by harnessing its intrinsic mid-ultraviolet (UV) autofluorescence. Two-photon excitation visible light (540 nm) conjunction a non-epifluorescent detection scheme is used to circumvent the UV toxicity and transmission problems. The method established imaging dopaminergic cell line...
Abstract Venlafaxine (VEN), a serotonin and noradrenaline reuptake inhibitor is being used as drug of choice for treating clinical depression even during pregnancy. It an important therapeutic option in the treatment perinatal depression, but effects VEN on fetus newborn are uncertain. Therefore, present study was undertaken to investigate safety in‐utero exposure terms developmental neurotoxicity neurodegenerative potential by using prenatal rat model. The selected doses (25, 40 50 mg/kg)...
Hypertension is reported to cause major brain disorders including Parkinson's disease (PD), apart from cardiovascular and chronic kidney disorders. Considering this, for the first time, we explored effect of modulation ACE2/Ang (1-7)/MasR axis using diminazene aceturate (DIZE), an ACE2 activator, in 6-hydroxydopamine (6-OHDA) induced PD model. We found that DIZE treatment improved neuromuscular coordination locomotor deficits 6-OHDA rat Further, DIZE-mediated activation led increased...
Loss of midbrain dopaminergic neurons in Parkinson's disease not only induces motor impairments but also leads to the development non-motor symptoms such as memory impairment, anxiety and depression. Dopaminergic axons directly innervate hippocampus release dopamine local environment hippocampus, hence are involved modulation hippocampal-dependent functions. Studies have explored potential effect on adult hippocampal neurogenesis. However, it is well defined whether oxidative damage...
The aggregation of neurotoxic amyloid-β (Aβ) polypeptides into aberrant extracellular senile plaques is the major neuropathological hallmark Alzheimer's disease (AD). Inhibiting these peptides to control progression this deadly can serve as a viable therapeutic option. In current work, inherently fluorescent theranostic dopamine–tryptophan nanocomposites (DTNPs) were developed and investigated for their amyloid inhibition propensity along with ability act cellular bioimaging agent in...
TTK21 is a small-molecule activator of p300/creb binding protein (CBP) acetyltransferase activity, which, upon conjugation with glucose-derived carbon nanosphere (CSP), can efficiently cross the blood–brain barrier and activate histone acetylation in brain. Its role adult neurogenesis retention long-term spatial memory following intraperitoneal (IP) administration well established. In this study, we successfully demonstrate that CSP-TTK21 be effectively administered via oral gavage. Using...
Synthesis of RΔF nanosphere-capped SeNPs with anti-amyloidogenic potency towards peptide aggregates. NPs can cross the BBB, exhibit protective effects against STZ-induced cytotoxicity in neuronal cells, and improve cognitive performance rat AD models.
TTK21 is a small molecule activator of p300/CBP acetyltransferase activity, which upon conjugation with glucose-derived carbon nanosphere (CSP) can efficiently cross the blood-brain barrier and activate histone acetylation in brain. Its role adult neurogenesis retention long-term spatial memory intraperitoneal (IP) administration well established. In this study, we have successfully demonstrated that CSP-TTK21 be effectively administered via oral gavage. Using combination molecular biology,...
Not much is known about disease prevalence, treatment outcomes, trained manpower, programs, and patients' awareness of diseases from South Asia, compared with the Western world. While other aspects are improving, quantitative evaluation lagging. Compared diseases, situation for mental health disorders addiction worse. no single study can fully quantify all awareness, a good starting point to understand if increasing number facilities beneficial by understanding people's perception toward...
Abstract Activation of the renin-angiotensin system (RAS), mediated by Angiotensin converting enzyme/Angiotensin II/Angiotensin receptor-1 (ACE/Ang II/AT1 R) axis elicits amyloid pathology, induces neurodegeneration and cognitive impairment leading to Alzheimer's disease (AD). On contrary, enzyme2 (ACE2) produces Ang -(1-7) which binds with Mas receptor counters ACE/Ang axis. To date, involvement ACE2/Ang-(1–7)/MasR in etiology progression AD largely remains be elucidated. Hence, present...