A5052713514- Natural Antidiabetic Agents Studies
- Prostate Cancer Treatment and Research
- Tuberculosis Research and Epidemiology
- Differential Equations and Numerical Methods
- Toxin Mechanisms and Immunotoxins
- Drug-Induced Hepatotoxicity and Protection
- Sperm and Testicular Function
- Cardiovascular Function and Risk Factors
- Herbal Medicine Research Studies
- Phytochemicals and Antioxidant Activities
- Advanced Mathematical Modeling in Engineering
- Liver Disease Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Essential Oils and Antimicrobial Activity
- Ethnobotanical and Medicinal Plants Studies
- Diabetes Treatment and Management
- Plant-Microbe Interactions and Immunity
- Cannabis and Cannabinoid Research
- Metabolism, Diabetes, and Cancer
- Reproductive Biology and Fertility
- Numerical methods for differential equations
- Phytochemicals and Medicinal Plants
- Immune Cell Function and Interaction
- Pharmacological Effects of Natural Compounds
- Mycobacterium research and diagnosis
Jamia Hamdard
2016-2025
University of Cincinnati
2011-2025
Ambedkar University Delhi
2024
Indian Institute of Science Education and Research Mohali
2017-2024
Institute of Nano Science and Technology
2017-2024
University of Nevada, Las Vegas
2024
University of Delhi
2023-2024
Central University of Himachal Pradesh
2024
Punjabi University
2024
Tribhuvan University Teaching Hospital
2020-2023
Stem cells support tissue maintenance by balancing self-renewal and differentiation. In mice, it is believed that a homogeneous stem cell population of single spermatogonia supports spermatogenesis, differentiation, which accompanied the formation connected (cysts) increasing length, linear nonreversible. We evaluated this model with use lineage analysis live imaging, found putative not homogeneous. Instead, pool steady-state spermatogenesis contained within subpopulation spermatogonia. also...
Standardized and reproducible preclinical models that recapitulate the dynamics of prostate cancer are urgently needed. We established a bank transplantable patient-derived xenografts capture biologic molecular heterogeneity currently confounding prognostication therapy development. Xenografts preserved histopathology, genome architecture, global gene expression donor tumors. Moreover, their aggressiveness matched patient observations, response to androgen withdrawal correlated with tumor...
The androgen-signaling pathway is important for the growth and progression of prostate cancer cells. growth-promoting effects androgen on cells are mediated mostly through receptor (AR). There increasing evidence that transcription activation by AR interaction with other cofactors. β-Catenin plays a critical role in embryonic development tumorigenesis its E-cadherin-mediated cell adhesion Wnt-dependent signal transduction. Here, we demonstrate specific protein-protein occurs between...
PI3K/Akt plays a critical role in prostate cancer cell growth and survival. Recent studies have shown that the effect of cells is mediated through androgen signaling. The PI3K inhibitor, LY294002, tumor suppressor, PTEN, negatively regulate pathway repress AR activity. However, molecular mechanisms whereby PTEN are currently unclear. Here, we demonstrate blocking reduces expression an endogenous target gene. Moreover, show repression activity by LY294002 phosphorylation inactivation GSK3β,...
Cytokinesis in somatic cells concludes with the formation of a midbody, which is abscised to form individual daughter cells. In contrast, germ cell cytokinesis results permanent intercellular bridge connecting through large cytoplasmic channel. During spermatogenesis, proposed roles for include communication, synchronization, and chromosome dosage compensation haploid Although several essential components midbody have recently been identified, vertebrate until now not described. Herein, we...
Summary A system for growing Geobacter sulfurreducens under anaerobic conditions in chemostats was developed order to study the physiology of this organism that might more closely approximate those found subsurface than batch cultures. could be cultured acetate‐limiting with fumarate or Fe(III)‐citrate as electron acceptor at growth rates between 0.04 and 0.09 h −1 . The molar yield threefold higher Fe(III), despite lower mid‐point potential fumarate/succinate redox couple. When limited by...
c-Jun NH<sub>2</sub>-terminal kinase (JNK) activation plays a major role in acetaminophen (APAP)-induced hepatotoxicity. However, the exact mechanism of APAP-induced JNK is incompletely understood. It has been established that apoptosis signal-regulating 1 (ASK1) regulates late phase activation, but mitogen-activated protein mediates initial not identified. Oxidative stress produced during APAP metabolism causes which promotes mitochondrial dysfunction and results amplification oxidative...
ABSTRACT In the murine testis, self-renewal of spermatogonial stem cells (SSCs) requires glial cell line-derived neurotrophic factor (GDNF) secreted from neighboring somatic cells. However, it not clear how GDNF promotes in vivo or what downstream signaling pathways are required for SSC maintenance. We found that is normally expressed cyclically during spermatogenesis. Stage-specific ectopic expression caused accumulation a GFRA1+ LIN28− Asingle population, which has enhanced activity...
Superoxide dismutases are metalloenzymes involved in protecting cells from oxidative damage arising superoxide radical or reactive oxygen species produced superoxide. Examples of enzymes containing Cu, Mn, and Fe as the redox-active metal have been characterized. Recently, a SOD one Ni atom per subunit was reported. The amino acid sequence NiSOD deduced nucleotide structural gene sodN Streptomyces seoulensis is reported has no homology with other SODs. X-ray absorption spectroscopic studies...
The androgen receptor (AR) is a hormone-dependent transcription factor that plays important roles in male sexual differentiation and development. Transcription activation by steroid hormone receptors, such as the receptor, mediated through interaction with cofactors. We recently identified novel AR-interacting protein, provisionally termed PAK6, shares high degree of sequence similarity p21-activated kinases (PAKs). PAK6 75-kDa protein contains putative amino-terminal Cdc42/Rac interactive...
The androgen receptor (AR), a member of the nuclear superfamily, plays central role in male sexual differentiation and prostate cell proliferation. Results treating cancer by ablation indicate that signals mediated through AR are critical for growth these tumors. Like other receptors, exerts its transcriptional function binding to<i>cis</i>-elements upstream promoters interacting with factors (<i>e.g.</i> activators, repressors modulators). To determine mechanism AR-regulated transcription,...
One of the hallmarks highly proliferative adult tissues is presence a stem cell population that produces progenitor cells bound for differentiation. Progenitor undergo multiple transit amplifying (TA) divisions before initiating terminal In male germline, daughter arising from spermatogonial rounds TA to produce undifferentiated clones interconnected 2, 4, 8, and 16 cells, collectively termed A(undifferentiated) (A(undiff)) spermatogonia, entering stereotypic differentiation cascade....
Abstract Background Hypoglycemic and/or anti-hyperglycemic activities have been recorded with numerous plants, many of which are used as traditional herbal treatments diabetes. Albizzia Lebbeck Benth. stem bark in medicine along some preliminary reports on its hypoglycemic action. The aim present investigation was to evaluate the antidiabetic and antioxidant methanolic extract streptozotocin induced diabetic rats. Methods powdered . extracted methanol (MeOH) using soxhlation method subjected...
Despite successful implementation of directly observed treatment, short course (DOTS) in India, the growing number diabetes mellitus (DM) patients appears to be a cause increasing tuberculosis (TB) incidence, affecting their management. In this regard, prospective study was conducted on DOTS three primary health care centers urban slum region South Delhi, evaluate effect DM sputum conversion, treatment outcome, and adverse drug reactions (ADR) due anti-TB treatment. Eligible TB underwent...
Ethanolic extract of Euryale ferox salisb. (EFx) may have an effect on the activity hepatic antioxidant enzymes, glycemic control and lipid profile histopathology pancreas, liver kidney streptozotocin (STZ)-induced diabetic wistar rats.
Albizzia Lebbeck Benth. is traditionally important plant and reported to possess a variety of pharmacological actions. The present research exertion was undertaken isolate characterized the flavonoids from extract stem bark evaluate efficacy isolated on in-vitro models type-II diabetes. Furthermore, results experimentation inveterate by molecular docking studies α-glucosidase α-amylase enzymes.Isolation methanolic A. Benth executed Silica gel (Si) column chromatography yield different...