A5083791441- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Synthesis and biological activity
- Nanoparticles: synthesis and applications
- Bee Products Chemical Analysis
- Essential Oils and Antimicrobial Activity
- Metabolism, Diabetes, and Cancer
- vaccines and immunoinformatics approaches
- Diabetes Treatment and Management
- Drug Transport and Resistance Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Curcumin's Biomedical Applications
- Laser-Ablation Synthesis of Nanoparticles
- Chemical Synthesis and Analysis
- Supramolecular Self-Assembly in Materials
- Adipose Tissue and Metabolism
- Phytochemicals and Medicinal Plants
- Cancer-related gene regulation
- Proteoglycans and glycosaminoglycans research
- Synthesis and Biological Evaluation
- Skin Protection and Aging
- Pharmacological Effects and Toxicity Studies
- COVID-19 Clinical Research Studies
- Phytochemicals and Antioxidant Activities
- Ginseng Biological Effects and Applications
B.J. Medical College
2020-2025
Gujarat University
2023-2024
Historically, plants have been sought after as bio-factories for the production of diverse chemical compounds that offer a multitude possibilities to cure diseases. To combat current pandemic coronavirus disease 2019 (COVID-19), plant-based natural are explored their potential inhibit SARS-CoV-2 (severe acute respiratory syndrome 2), cause COVID-19. The present study is aimed at investigation antiviral action several groups phytoconstituents against using molecular docking approach Main...
Phytochemicals encompass a diverse array of bioactive substances originating from plants, exhibiting broad spectrum possible health-promoting effects. Nonetheless, the clinical uses these compounds are restricted due to their limited solubility, stability, bioavailability, and target selectivity. Nanotechnology-based delivery methods present viable approach address problems enhance properties biological activity phytochemicals. Nanoformulations have potential augment pharmacokinetics...
The inadequate clinical efficacy of the present anti-Alzheimer's disease (AD) drugs and their low impact on progression Alzheimer's in patients have revised research focus from single targets to multitarget-directed ligands. A novel series substituted triazinoindole derivatives were obtained by introducing various substituents indole ring for development ligands as anti-AD agents. experimental data indicated that some these compounds exhibited significant properties. Among them,...
Kishan B. Patela, Dushyant V. Nirav R. Ashish M. Kanhedb, Divya Telic, Bhumi Gandhia, Bhavik S. Shaha, Bharat N. Chaudharya, Navnit K. Prajapatia, Kirti Patela & Mange Ram Yadavad*a Faculty of Pharmacy, The Maharaja Sayajirao University Baroda, Vadodara, Gujarat, Indiab Shobhaben Pratapbhai Patel – School Pharmacy Technology Management, SVKM's NMIMS University, Mumbai, Indiac Department Pharmaceutical Chemistry, L. College Navrangpura, Indiad Centre Research for Development, Parul India
Abstract Neurological disease epilepsy has unfortunately become widespread, affecting around 50 million individuals worldwide. Levetiracetam (LVM) is a newer‐generation drug but its hydrophilic nature restricts BBB (blood‐brain barrier) permeability. This results in increased dose, dosing frequency, and side effects. Therefore, different lipid‐drug conjugates (LDCs) were studied to identify the compound capable of permeation. The binding potential LDCs with human brain fatty‐acid protein...
Abstract Polycystic Ovary Syndrome (PCOS) is a widespread and complex hormonal disorder occurs in women of reproductive age, characterized by imbalances ovarian dysfunction. Current approaches to treating PCOS often address specific symptoms, highlighting the demand for innovative therapeutic agents that can tackle its multifaceted nature. The present study endeavors investigate potential new chromen‐2‐one derivatives management PCOS. A total 30 have been synthesized evaluated their vitro...
Abstract With aim of developing the crucial pharmacophoric properties reported EGFR inhibitors (EGFRIs), a series thiophene compounds having ethyl 5‐methylthiophene‐3‐carboxylate core were designed. The designed subjected to molecular docking studies that indicated potentialities AP−A8, A9, A13 and A15 be EGFRIs. Then, MD simulations confirmed stability correct binding compound AP−A15 – complex at both energetic conformational levels. Furthermore, in silico ADMET prediction revealed majority...