A5081844519- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Mechanical Circulatory Support Devices
- Long-Term Effects of COVID-19
- Infectious Encephalopathies and Encephalitis
- Autoimmune Neurological Disorders and Treatments
- Synthesis and biological activity
- Quality and Safety in Healthcare
- Pneumothorax, Barotrauma, Emphysema
- Biomedical and Engineering Education
- Airway Management and Intubation Techniques
- Renal function and acid-base balance
- COVID-19 Clinical Research Studies
- Liver Disease and Transplantation
- Peripheral Neuropathies and Disorders
- Hemodynamic Monitoring and Therapy
- Immunodeficiency and Autoimmune Disorders
- Mycobacterium research and diagnosis
- Click Chemistry and Applications
- Cardiac electrophysiology and arrhythmias
- COVID-19 Impact on Reproduction
- Cardiac Arrest and Resuscitation
- Infection Control and Ventilation
- Cancer therapeutics and mechanisms
Baylor College of Medicine
2017-2024
Sankalchand Patel University
2023
Sardar Patel University
2023
University of Kansas
2020
Northwell Health
2013
Pulmonary Associates
2013
Pulmonary vascular microthrombi are a proposed mechanism of COVID-19 respiratory failure. We hypothesized that early administration tissue plasminogen activator (tPA) followed by therapeutic heparin would improve pulmonary function in these patients.
A 50-year-old woman with a recent diagnosis of poorly differentiated nonteratomatous cervicouterine cancer presented to our hospital for breath-holding episodes resulting in perioral cyanosis. Her medical history was significant chickenpox at age 8 and shingles 15. Before her admission 10 days after diagnosis, she admitted an outside confusion intermittent catatonia. Workup the unremarkable, diagnosed adjustment disorder. At home, continued decompensate ultimately became incomprehensible,...
Pulmonary alveolar proteinosis (PAP) is a rare syndrome due to increased production or decreased clearance of surfactant in alveoli and terminal bronchi that cause hypoxemic respiratory insufficiency. Here we present patient with PAP whose disease was exacerbated by superimposed COVID-19 pneumonia. He underwent whole lung lavage (WLL). Evaluation the viral count first last left showed load space dropped approximately 10-folds, however magnitude substantial both samples. Whole pulmonary may...
Abstract With aim of developing the crucial pharmacophoric properties reported EGFR inhibitors (EGFRIs), a series thiophene compounds having ethyl 5‐methylthiophene‐3‐carboxylate core were designed. The designed subjected to molecular docking studies that indicated potentialities AP−A8, A9, A13 and A15 be EGFRIs. Then, MD simulations confirmed stability correct binding compound AP−A15 – complex at both energetic conformational levels. Furthermore, in silico ADMET prediction revealed majority...
Early case series have suggested that 20%-31% of COVID-19 patients will develop acute respiratory distress syndrome and require intensive care, potentially causing a nationwide shortage mechanical ventilators.We present review the high-flow nasal cannula which presents several physiological benefits in failure.It is safe treatment modality with low risk exposure to aerosolized viral particles for health-care workers setting negative-pressure or high-efficiency particulate air-filtered rooms...
Pulmonary alveolar proteinosis (PAP) is a rare syndrome due to increased production or decreased clearance of surfactant in alveoli and terminal bronchi that cause hypoxemic respiratory insufficiency. Here we present patient with past medical history PAP whose disease was exacerbated by superimposed COVID-19 pneumonia. He underwent whole pulmonary lavage (WPL). Evaluation the viral count first last left lung showed load space dropped approximately 10-folds, however magnitude substantial both...
Common neurological emergencies include overdose or withdrawal from illegal substance abuse, adverse effects of prescription medications, seizures, metabolic encephalopathy, infections and cerebrovascular accidents.Following a thorough clinical radiologic assessment, small group patients escape definitive diagnosis autoimmune encephalitides should be considered.Of these, limbic encephalitis (LE) is the most common may result paraneoplastic nonparaneoplastic sources.Common to both production...
Background: Pulmonary vascular microthrombi have been proposed as a mechanism of COVID19 respiratory failure. We hypothesized that early administration tissue-plasminogen activator(tPA) followed by therapeutic heparin would improve pulmonary function in these patients.Methods: Adults with COVID-19-induced failure were randomized May14, 2020-March 3, 2021 two phases: Phase-1(n=36): control (standard-of-care) vs tPA-Bolus (50mg tPA IV-bolus 7 days (goal aPTT=60-80s); Phase-2(n=14): tPA-Drip...
Pulmonary alveolar proteinosis (PAP) is a rare syndrome due to increased production or decreased clearance of surfactant in alveoli and terminal bronchi that cause hypoxemic respiratory insufficiency. Here we present patient with past medical history PAP whose disease was exacerbated by superimposed COVID-19 pneumonia. He underwent whole pulmonary lavage (WPL). Evaluation the viral count first last left lung showed load space dropped approximately 10-folds, however magnitude substantial both...
Abstract One of the diseases in 21 st century is still cancer and there significant research being done all over world to find a medicine that more effective has fewer adverse effects. More than 19 million new cases have been reported by global statistics an estimated 10 people died from it 2020. We continue work on development pharmacological entities because we are motivated area. created novel thiophene derivatives screened them against U87‐MG cell line see whether they any anticancer...
Introduction: Pneumomediastinum is a rare clinical finding defined by air occupying potential space in the mediastinum. Bilateral pulmonary opacities including consolidations and ground glass opacifications are some of radiological manifestations COVID-19 infection. There has been recent sporadic reports pneumomediastinum patients with COVID-19. Spontaneous or primary generally occurs when no underlying factors can be identified. Secondary due to traumatic causes non-traumatic respiratory...