A5073632652- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Neonatal Respiratory Health Research
- Fatty Acid Research and Health
- Congenital Diaphragmatic Hernia Studies
- Pulmonary Hypertension Research and Treatments
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Pharmaceutical studies and practices
- Liver Disease Diagnosis and Treatment
- Bone health and osteoporosis research
- Vitamin K Research Studies
- Long-Term Effects of COVID-19
- Bone and Joint Diseases
- Health and Medical Research Impacts
- Hemoglobinopathies and Related Disorders
- Infant Nutrition and Health
- RNA modifications and cancer
- Orthopaedic implants and arthroplasty
- Pediatric Hepatobiliary Diseases and Treatments
- Renal function and acid-base balance
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- COVID-19 Clinical Research Studies
Boston Children's Hospital
2016-2023
Harvard University
2013-2023
Beth Israel Deaconess Medical Center
2012-2022
Boston Children's Museum
2019-2021
Center for Vascular Biology Research
2016-2018
Pulmonary vascular microthrombi are a proposed mechanism of COVID-19 respiratory failure. We hypothesized that early administration tissue plasminogen activator (tPA) followed by therapeutic heparin would improve pulmonary function in these patients.
Vascular endothelial growth factor (VEGF) has previously been demonstrated to accelerate compensatory lung (CLG) in mice and may be a useful therapy for pulmonary hypoplasia. Systemic administration of VEGF can result side effects such as hypotension edema. The aim this study was explore nasal delivery route intrapulmonary administration. Eight-week-old C57BL/6 male underwent left pneumonectomy, followed by daily instillation at 0.5 mg/kg or isovolumetric saline. Lung volume measurement,...
Polyunsaturated fatty acids serve multiple functions in neurodevelopment and neurocognitive function. Intravenous lipid emulsions are administered to children that dependent on parenteral nutrition provide the essential needed sustain growth development. One of these emulsions, derived from fish-oil, is particularly poor traditional acids, linoleic alpha-linolenic acids. However, it does contain adequate amounts its main derivatives, arachidonic acid (ARA) docosahexaenoic (DHA),...
Intestinal failure-associated liver disease (IFALD) is a risk of parenteral nutrition (PN)-dependence. Intravenous soybean oil-based fat can exacerbate the IFALD while intravenous fish oil minimize its progression, yet mechanisms by which harms and protects are uncertain. Properties that differentiate oils include α-tocopherol phytosterol content. Soybean rich in phytosterols contains little α-tocopherol. Fish abundant phytosterols. This study tested whether confers hepatoprotective...
Background Few therapies exist to treat severe COVID-19 respiratory failure once it develops. Given known diffuse pulmonary microthrombi on autopsy studies of patients, we hypothesized that tissue plasminogen activator (tPA) may improve function in failure. Methods A multicenter, retrospective, observational study patients with confirmed and who received systemic tPA (alteplase) was performed. Seventy-nine adults from seven medical centers were included the final analysis after institutional...
Intestinal failure-associated liver disease (IFALD), initially manifesting as cholestasis, is a complication in neonates receiving parenteral nutrition (PN). Soybean oil lipid emulsion (SOLE), though implicated IFALD, was the only US Food and Drug Administration (FDA)-approved initial intravenous (ILE) for infants children United States. A mixed-oil (MOLE) gained popularity patients at risk IFALD recently FDA approved an ILE children. Given presence of soybean MOLE, we hypothesized that MOLE...
Background: Fat emulsions are important components of parenteral nutrition (PN). Fish oil (FO) reverse cholestasis in PN‐associated liver disease. There 2 FO monographs. One is “FO; rich omega‐3 fatty acids” (NFO). The other, “omega‐3 acids,” (PFO), enriched acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic (DHA). purpose this study to compare the effects 20% NFO PFO produced laboratory a murine model. Methods: Emulsions were compounded containing different oils: soybean...
High resolution μCT, and combined μPET/CT have emerged as non-invasive techniques to enhance or even replace dual energy X-ray absorptiometry (DXA) the current preferred approach for fragility fracture risk assessment. The aim of this study was assess ability µPET/CT imaging differentiate changes in rat bone tissue density microstructure induced by metabolic diseases more accurately than available methods.Thirty three rats were divided into groups control, ovariectomy vitamin-D deficiency....
Hemostatic agents, tissue adhesives and sealants may contribute to a reduction in hemorrhage-associated morbidity mortality. Towards this end, we have recently developed lysine-based dendritic hydrogel (PEG-LysNH2) that can potentially be used the management of severe trauma and/or intraoperative bleeding. As first step demonstrating potential utility approach, our objective was ascertain ability PEG-LysNH2 adhere seal injured tissues, as well maintain under physiological conditions. The...
Anez‐Bustillos, Lorenzo; Dao, Duy T.; Potemkin, Alexis K.; Perez‐Atayde, Antonio R.; Raphael, Bram P.; Carey, Alexandra N.; Kamin, Daniel S.; Thiagarajah, Jay Crowley, McGreggor; Gura, Kathleen M.; Puder, Mark Author Information
Abstract Background Preterm delivery and current nutrition strategies result in deficiencies of critical long‐chain fatty acids (FAs) lipophilic nutrients, increasing the risk preterm morbidities. We sought to determine efficacy preventing postnatal deficits FAs nutrients using an enteral concentrated lipid supplement piglets. Methods piglets were fed a baseline diet devoid arachidonic acid (AA) docosahexaenoic (DHA) randomized supplementation as follows: (1) Intralipid (IL), (2) complex 1...