A5038946983- Cardiovascular Health and Risk Factors
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- CAR-T cell therapy research
- Nutrition and Health in Aging
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer-related cognitive impairment studies
- Dementia and Cognitive Impairment Research
- Smoking Behavior and Cessation
- Atherosclerosis and Cardiovascular Diseases
- Cancer survivorship and care
- Congenital heart defects research
- GDF15 and Related Biomarkers
- Dermatological and Skeletal Disorders
- Cardiac tumors and thrombi
- COVID-19 and healthcare impacts
- Parathyroid Disorders and Treatments
- Medical Imaging and Pathology Studies
- Cancer Immunotherapy and Biomarkers
- Pulmonary Hypertension Research and Treatments
- Cancer Treatment and Pharmacology
- Epigenetics and DNA Methylation
- Global Public Health Policies and Epidemiology
- Intensive Care Unit Cognitive Disorders
Cedars-Sinai Medical Center
2024
University of California, Los Angeles
2022-2023
Ronald Reagan UCLA Medical Center
2021-2023
Boston University
2017-2022
Los Angeles Medical Center
2022
Boston Medical Center
2022
Boston Children's Hospital
2018
Human aging is associated with an increased frequency of somatic mutations in hematopoietic cells. Several these recurrent mutations, including those the gene encoding epigenetic modifier enzyme TET2, promote expansion mutant blood This clonal hematopoiesis correlates risk atherosclerotic cardiovascular disease. We studied effects Tet2-mutant cells atherosclerosis-prone, low-density lipoprotein receptor-deficient (Ldlr-/-) mice. found that partial bone marrow reconstitution TET2-deficient...
We report disease-specific cardiovascular causes of mortality among cancer patients in the USA between 1999 and 2019, considering temporal trends by age, sex, site.
Background: Echocardiographic deformation-based ratios and novel multi-parametric scores have been suggested to discriminate transthyretin cardiac amyloidosis (ATTR-CM) from other causes of increased left ventricular wall thickness among patients referred for ATTR-CM evaluation. Their relative predictive accuracy has not well studied. We sought (1) identify echocardiographic parameters (2) compare the diagnostic these in with suspected technetium-99m-pyrophosphate scintigraphy. Methods:...
Vascular endothelial growth factor (VEGF) has previously been demonstrated to accelerate compensatory lung (CLG) in mice and may be a useful therapy for pulmonary hypoplasia. Systemic administration of VEGF can result side effects such as hypotension edema. The aim this study was explore nasal delivery route intrapulmonary administration. Eight-week-old C57BL/6 male underwent left pneumonectomy, followed by daily instillation at 0.5 mg/kg or isovolumetric saline. Lung volume measurement,...
Background: Chimeric antigen receptor T-cell (CAR-T) therapy targeting CD-19 utilizes ex-vivo engineered T-cells to treat refractory malignancies. Widespread CAR-T adoption is limited by resource utilization and cost, has also been associated with adverse cardiovascular events. Limited data exist exploring the relationship between CAR-T-associated events (RUE). Objective: To evaluate whether are RUE. Methods: Records of patients treated an FDA-approved product 2018 2022 at a single...
Systemic amyloidosis – which causes organ dysfunction by extracellular deposition of misfolded protein fibrils into various organs is substantially underdiagnosed. Recent breakthroughs in highly ...
Abstract Introduction Chimeric antigen receptor (CAR) T-cell therapy, which involves ex-vivo engineering of autologous T-cells against cancer cells, has transformed the management B and plasma cell malignancies, leading to further efforts in identifying new targets indications. As use CAR T therapy expands, understanding its effects on cardiovascular (CV) system becomes increasingly relevant. The systemic inflammatory response elicited by can result cytokine release syndrome (CRS) with...
Introduction: The COVID-19 pandemic has highlighted important socioeconomic health disparities in the United States. Both cardiovascular disease (CVD) and cancer are associated with worse outcomes. We describe racial or ethnic, sex, rural mortality rates from US cardio-oncology (C-O) population concurrent CVD. Methods: Using multiple causes of death data files within CDC WONDER, we assessed survival outcomes March to December 2020 (most intense for deaths) by race ethnicity, status. C-O...
Introduction: Cardiovascular disease and cancer are major causes of morbidity mortality in the United States. Risk acute myocardial infarction (AMI) is elevated patients, which may be due to shared risk factors as well cardiotoxicity oncologic therapies. This study aims estimate burden from AMI States population identify demographics affected populations. Methods: Data were obtained multiple death data files CDC WONDER 1999-2019. All deaths with ICD 10 code I21 for “acute infarction” listed...