A5049768105- Marine Sponges and Natural Products
- Legionella and Acanthamoeba research
- Seaweed-derived Bioactive Compounds
- Marine Biology and Environmental Chemistry
- Essential Oils and Antimicrobial Activity
- Marine Biology and Ecology Research
- Marine Toxins and Detection Methods
- Marine and coastal plant biology
- Vibrio bacteria research studies
- Microbial Community Ecology and Physiology
- Infectious Diseases and Mycology
- X-ray Diffraction in Crystallography
- Plant-Derived Bioactive Compounds
- Hydrogen's biological and therapeutic effects
- Phytochemical compounds biological activities
- Marine Ecology and Invasive Species
- Heme Oxygenase-1 and Carbon Monoxide
- Crystallization and Solubility Studies
- Sesquiterpenes and Asteraceae Studies
- Various Chemistry Research Topics
- Phytochemicals and Antioxidant Activities
- Carcinogens and Genotoxicity Assessment
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Microbial Natural Products and Biosynthesis
Universidad de La Laguna
2018-2025
Institute of Organic Chemistry
2020
Universidad Autónoma de Nuevo León
2018-2019
Instituto Politécnico Nacional
2018
Focused on our interest to develop novel antiparasistic agents, the present study was aimed evaluate biological activity of an extract Laurencia johnstonii collected in Baja California Sur, Mexico, against Acantamoeba castellanii Neff strain. Bioassay-guided fractionation allowed us identify amoebicidal diastereoisomers α-bromocuparane (4) and α-isobromocuparane (5). Furthermore, bromination inactive laurinterol (1) isolaurinterol (2) yielded four halogenated derivatives, (6)⁻(9), which...
Abstract Primary amoebic encephalitis (PAM) is a lethal disease caused by the opportunistic pathogen, Naegleria fowleri . This species able to live freely in warm aquatic habitats and infect children young adults when they perform risk activities these water bodies such as swimming or splashing. Besides need increase awareness of PAM which will allow an early diagnosis, development fully effective therapeutic agents needed. Current treatment options are amphotericin B miltefosine not also...
Among neglected tropical diseases, leishmaniasis is one of the leading causes, not only deaths but also disability-adjusted life years. This disease, caused by protozoan parasites genus Leishmania, triggers different clinical manifestations, with cutaneous, mucocutaneous, and visceral forms. As existing treatments for this parasitosis are sufficiently effective or safe patient, in work, sesquiterpenes isolated from red alga Laurencia johnstonii have been studied purpose. The compounds were...
Macroalgae represent an important source of bioactive compounds with a wide range biotechnological applications. Overall, the discovery effective cytotoxic pharmaceutical potential is significant challenge, mostly because they are scarce in nature or their total synthesis not efficient, while bioprospecting models currently used do predict clinical responses. Given this context, we three-dimensional (3D) cultures human breast cancer explants to evaluate antitumoral effect laurinterol, major...
Primary amoebic meningoencephalitis (PAM) is a central nervous system (CNS) disease caused by Naegleria fowleri that mainly affects children and young adults with fatal consequences in most of the cases. Treatment protocols are based on combination different antimicrobial agents, nonetheless there need to develop new anti-Naegleria compounds low toxicity full effects compared currently used drug combination. The marine environment well-established source bioactive natural products. In this...
Marine environments represent a great opportunity for the discovery of compounds with wide spectrum bioactive properties. Due to their large variety and functions derived from natural selection, marine products may allow identification novel drugs based not only on newly discovered metabolites but also already known yet thoroughly investigated. Since drug resistance has caused an increase in infections by Mycobacterium tuberculosis nontuberculous mycobacteria, re-evaluation been suggested as...
We describe five new isolates of two Gambierdiscus species from Bahía de La Paz in the southern Gulf California. Batch cultures were established for morphological characterization using light microscopy (LM) and scanning electron (SEM). Pigment amino acid profiles also analyzed high-performance liquid chromatography (HPLC-UV HPLC-DAD). Finally, toxicity (CTX-like MTX-like activity) was evaluated Artemia salina assay (ARTOX), mouse (MBA), marine fish (MFA), fluorescent receptor binding...
Background and Objective: Marine environment represents countless diverse resource for new drugs to combat major diseases.Extracts from four Laurencia species (L.johnstonii, L. pacifica, gardneri papillosa) Baja California Sur, México were evaluated their antioxidant, antibacterial cytotoxic activity.Methodology: The antioxidants activity of sp. using the radical scavenging in three vitro radicals: 1,1-Diphenyl-2-picrylhydrazyl (DPPH), 2,2'-Azino-bis (3-ethylbenzthiazoline-6-sulfonic acid)...
Marine ecosystems are unique and rich reservoirs of biodiversity with high potential toward improving the quality human life. The extreme physical–chemical conditions oceans have favored marine organisms to produce a great variety new molecules as mechanism ensure their survival, such compounds possess biopharmaceutical interest. In particular, microbiota represent promising inexhaustible source for development drugs. This work presents taxonomic study samples obtained from underwater...
Precision-cut tissue slices are considered an organotypic 3D model widely used in biomedical research. The comet assay is important screening test for early genotoxicity risk assessment that mainly applied on vitro models. aim of the present study was to provide a organ system determination using modified method since stromal components from original make this technique complicated.A validated precision-cut hamster kidney analyze antigenotoxic effect phenolic compounds caffeic acid,...
Amoebiasis is a parasitic disease that causes thousands of deaths every year, its adverse effects and resistance to conventional treatments have led the search new treatment options, as well development novel screening methods. In this work, we implemented 3D model intestine liver slices from hamsters were infected ex vivo with virulent E. histolytica trophozoites. Results show preserved histology in both uninfected tissues ulcerations, destruction epithelial cells, inflammatory reaction...
is a shrub with yellow flowers that reach up to two meters high, endemic of the Atacama Region in Chile. This species grows under special environmental conditions such as low altitude, arid areas, and directly sun-exposed habitats. In present study, ethanolic extract was obtained from fruits
<title>Abstract</title> A biofilm is a complex microbial community, representing the initial stage in biofouling formation. Consequently, it responsible for significant economic losses several industrial sectors worldwide. Therefore, there constant need safer and environmentally friendly coatings, particularly those derived from new marine sources such as seaweeds with antifouling properties. Red algae produce metabolites that prevent bacterial attachment formation by disrupting membranes,...
Marine environments represent a great opportunity for the discovery of compounds with wide spectrum bioactive properties. Due to privileged conditions natural selection, marine products are subject overcome pressure put on identify novel drugs; not only in case newly discovered metabolites, but also those previously known. Since drug resistance has caused an increase infections by tuberculous and nontuberculous Mycobacteria, re-evaluation known metabolites been suggested as means address...
Background and Objective: Invertebrates comprises more than fifty percent of marine animals.Among them, sponges are the most prolific source bioactive compounds.Suberites aurantiacus (S. aurantiacus) is an abundant sponge in Mexican Pacific, which has been scarcely studied, for this reason authors screened it its bioactivities.The current study proposed to determine enzymatic inhibition scavenger, toxic antibacterial activities from Suberites aurantiacus.Materials Methods: S. samples were...