A5060913124- Carbohydrate Chemistry and Synthesis
- Cholinesterase and Neurodegenerative Diseases
- Glycosylation and Glycoproteins Research
- Polyamine Metabolism and Applications
- Organoselenium and organotellurium chemistry
- Synthesis of Organic Compounds
- Computational Drug Discovery Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Enzyme Catalysis and Immobilization
- Chemical Synthesis and Analysis
- Synthesis and biological activity
- Enzyme function and inhibition
- Edible Oils Quality and Analysis
- Natural product bioactivities and synthesis
- Synthesis and Reactions of Organic Compounds
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Genomics, phytochemicals, and oxidative stress
- Chemical Synthesis and Reactions
- Lysosomal Storage Disorders Research
- Phytochemicals and Antioxidant Activities
- Synthesis and Catalytic Reactions
- Enzyme Production and Characterization
- Phytochemistry and Biological Activities
Universidad de Sevilla
2016-2025
University Hospital Heidelberg
2024
Heidelberg University
2024
Rede de Química e Tecnologia
2011-2021
Faculty (United Kingdom)
2017
IVI Sevilla Clinic
2017
University of Copenhagen
2011
University of Bologna
2007
Università di Camerino
2007
University College Dublin
2004
Hydroxytyrosol is a phenol found predominantly in the olive tree (Olea europea). It shows broad spectrum of beneficial effects such as cancer chemoprevention by inducing apoptosis, cardioprotection and anti-atherogenic activity, skin photoprotection anti-inflammatory activity. These biological properties are based on scavenging reactive oxygen species hydroxytyrosol, being more active than antioxidant vitamins synthetic antioxidants. Its activities human health has stimulated development new...
Scope Hydroxytyrosol acetate (HTy-Ac), an extra virgin olive oil (EVOO) polyphenol, has recently been reported to exhibit antioxidant and anti-inflammatory effects on LPS-stimulated macrophagesand ulcerative colitis. This study was designed evaluate dietary HTy-Ac supplementation collagen-induced arthritis (CIA) in mice. Methods results DBA-1/J mice were fed from weaning with 0.05% HTy-Ac. After 6 weeks, induced by type II collagen. Mice sacrificed 42 days after first immunization. Blood...
Insecticides have a pivotal role in our lives, not only for crop protection agriculture, but also to avoid the spreading of harmful pests causing human diseases such as malaria. Due economic and medical reasons, design effective agents that control these is quite an important task agrochemical science industrial sector. Nevertheless, non-restricted use highly toxic insecticides several decades has provoked negative effects environment poisoning non-targeted species. For development selective...
This work evaluated the effects of extra virgin olive oil (EVOO) phenols, hydroxytyrosyl acetate (2) and 3,4-dihydroxyphenylglycol (3), as well two new acyl derivatives 3, 4-(1,2-di(butanoyloxy)ethyl)benzene-1,2-diol (7) 4-(1,2-di(lauroyloxy)ethyl)benzene-1,2-diol (8), on LPS-stimulated murine peritoneal macrophages in comparison with hydroxytyrosol (HTy, 1). Compounds 2, 7, 8 showed a strong reactive oxygen species (ROS)-scavenging activity, reducing significantly nitrite levels significant...
Starting from natural steroids (diosgenin, hecogenin, smilagenin, estrone), we have prepared a wide panel of selenoderivatives, including benzoselenazolones, selenosemicarbazones, isoselenocyanates, selenoureas, selenocyanates and diselenides, with the aim developing new families potential chemotherapeutic agents. The modification organoselenium moieties, their position on steroid provided valuable information concerning antiproliferative activities. Among all accessed herein, best profile...
Being aware of the need to develop more efficient therapies against cancer, herein we disclose an innovative approach for design selective antiproliferative agents. We have accomplished conjugation a coumarin fragment with lipophilic cations (triphenylphosphonium salts, guanidinium) providing mitochondriotropic agents that simultaneously target also carbonic anhydrases IX and XII, involved in development progression cancer. The new compounds prepared turned out be strong inhibitors XII human...
Coumarin–azasugar–benzyl conjugates were obtained through the CuAAC reaction, displaying dual anti-Alzheimer and anti-cancer activity in vitro no neurotoxicity.
The selective inhibition of key enzymes, such as carbonic anhydrases (CAs IX and XII), which are overexpressed in cancer tissues, has emerged a promising strategy research. However, multitarget approach is often preferred to achieve enhanced therapeutic outcomes. In this study, aryl sulfonamides were conjugated with thiosemicarbazone moiety enable dual functionality: the CAs chelation metal cations. Several structural factors systematically modified, including position sulfonamido group,...
The effect of conformation on glycoside reactivity was investigated by studying the hydrolysis a selection 3,6-anhydroglucosides as models for glucose in highly reactive 1C4 conformation. Methyl 3,6-anhydro-β-d-glucopyranoside found to hydrolyze 200−400 times faster than methyl glucosides 4C1 conformation, while 3,6-anhydro-β-d-galactopyranoside, which is B1,4 less β-d-galactopyranoside. (3,6-anhydro-β-d-glucopyranosyl)-(1 → 6)-α-d-glucopyranoside, (3,6-anhydro-α-d-glucopyranosyl)-(1...
The Knoevenagel condensation of aldose sugars with β-dicarbonyl compounds produces furan derivatives having polyhydroxyalkylated alkyl side chains; this reaction is known as the Garcia Gonzalez reaction. Despite fact that these polyhydroxyalkyl furans are interesting scaffolds for synthetic chemists to utilize in synthesis a variety biologically molecules, reported approach suffers from harsh conditions. development general and more efficient protocol considerable importance, manuscript, we...
The present study was designed to investigate the role of canonical and noncanonical inflammasome, MAPKs NRF-2/HO-1, signaling pathways involved in antioxidant anti-inflammatory activities oleocanthal lipopolysaccharide (LPS)-stimulated murine peritoneal macrophages. Isolated cells were treated with presence or absence LPS (5 μg mL-1) for 18 h. Oleocanthal showed a potent reduction reactive oxygen species (ROS) (25 μM, 50. 612 ± 0.02; 50 53. 665 0.09; 100 52. 839 0.02), nitrites 0.631 0.07;...