Jennifer V. Wethe
A5039193836- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Advanced Neuroimaging Techniques and Applications
- Injury Epidemiology and Prevention
- Advanced MRI Techniques and Applications
- Stroke Rehabilitation and Recovery
- Trauma and Emergency Care Studies
- Dementia and Cognitive Impairment Research
- Cognitive Functions and Memory
- Functional Brain Connectivity Studies
- Olfactory and Sensory Function Studies
- Cerebral Palsy and Movement Disorders
- Resilience and Mental Health
- Sport Psychology and Performance
- MRI in cancer diagnosis
- Cardiovascular Effects of Exercise
- Spinal Cord Injury Research
- Fetal and Pediatric Neurological Disorders
- Cholinesterase and Neurodegenerative Diseases
- Reading and Literacy Development
- Medical Imaging Techniques and Applications
- Neurosurgical Procedures and Complications
Mayo Clinic in Arizona
2017-2025
Mayo Clinic Hospital
2016-2025
Boston University
2021-2024
Alzheimer's Association
2024
WinnMed
2021-2023
Landscape Research Group
2023
Authorised Association Consortium
2023
Mayo Clinic in Florida
2021-2023
VA San Diego Healthcare System
2023
University of California, San Diego
2023
As part of an initiative led by the Brain Injury Special Interest Group Mild Traumatic (TBI) Task Force American Congress Rehabilitation Medicine (ACRM) to update 1993 ACRM definition mild TBI, present study aimed characterize current expert opinion on diagnostic considerations.Cross-sectional web-based survey.Not applicable.An international, interdisciplinary group clinician-scientists (N=31) with expertise in TBI completed survey invitation between May and July 2019 (100% completion...
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that has been neuropathologically diagnosed in brain donors exposed to repetitive head impacts, including boxers and American football, soccer, ice hockey, rugby players. CTE cannot yet be during life. In December 2015, the National Institute of Neurological Disorders Stroke awarded seven-year grant (U01NS093334) fund "Diagnostics, Imaging, Genetics Network for Objective Study Evaluation Traumatic Encephalopathy (DIAGNOSE...
Abstract Background Patterns of cognitive impairment in former American football players are uncertain because objective neuropsychological data lacking. This study characterized the test performance college and professional players. Methods One hundred seventy male ( n =111 professional, =59 college; 45–74 years) completed a battery. Raw scores were converted to T -scores using age, sex, education-adjusted normative data. A -score ≤ 35 defined impairment. domain was impaired if 2+ fell...
Traumatic encephalopathy syndrome (TES) is defined as the clinical manifestation of neuropathological entity chronic traumatic (CTE). A core feature TES neurobehavioral dysregulation (NBD), a neuropsychiatric in repetitive head impact (RHI)-exposed individuals, characterized by poor regulation emotions/behavior. To discover biological correlates for NBD, we investigated association between biomarkers inflammation (interleukin (IL)-1β, IL-6, IL-8, IL-10, C-reactive protein (CRP), tumor...
Objective To determine whether patients with traumatic brain injury (TBI) report higher levels of fatigue than do normal controls and to identify demographic cognitive correlates self-reported fatigue. Design Prospective study. Setting Inpatient neurorehabilitation unit in a medical center neurological institute. Participants Forty-seven inpatients TBI. Main Outcome Measures Barrow Neurological Institute (BNI) Fatigue Scale BNI Screen for Higher Cerebral Functions. Results Patients reported...
Abstract Introduction The presentation, risk factors, and etiologies of white matter hyperintensities (WMH) in people exposed to repetitive head impacts are unknown. We examined the burden distribution WMH, their association with years play, age first exposure, clinical function former American football players. Methods A total 149 players 53 asymptomatic unexposed participants (all men, 45–74 years) completed fluid‐attenuated inversion recovery magnetic resonance imaging, neuropsychological...
Background and ObjectivesRecent data link exposure to repetitive head impacts (RHIs) from American football with increased white matter hyperintensity (WMH) burden. WMH might have unique characteristics in the context of RHI beyond vascular risk normal aging processes. We evaluated biological correlates former players, including markers amyloid, tau, inflammation, axonal injury, neurodegeneration, health.MethodsParticipants underwent clinical interviews, MRI, lumbar puncture as part...
Address deficiencies in access to sports sideline medical care by using a Concussion Check Protocol (CCP) for non-medically-trained people.
Objective: Cognitive impairment is a core feature of traumatic encephalopathy syndrome (TES), the putative clinical chronic encephalopathy—a neuropathological disease associated with repetitive head impacts (RHI). Careful operationalization cognitive essential to improving diagnostic specificity and accuracy TES criteria. We compared single- versus two-test criteria for in their associations CSF imaging biomarkers male former American football players. Method: 169 participants from DIAGNOSE...
Background: Exposure to repetitive head impacts (RHI), such as those experienced in American football, is linked cognitive dysfunction later life. Traumatic encephalopathy syndrome (TES) a proposed clinical thought be neuropath-ology of chronic traumatic (CTE), condition associated with RHI from football. Cognitive intra-individual variability (d-CIIV) measures test-score dispersion, indicating dysfunction. This study examined d-CIIV former football players and its associations TES...
Disturbances in brain catecholamine activity may be associated with symptoms after exposure to repetitive head impacts (RHIs) or related chronic traumatic encephalopathy (CTE). In this article, we studied CSF catecholamines former professional and college American football players examined the relationship proxies of RHI exposure, CTE probability, cognitive performance, neuropsychiatric symptoms, parkinsonism. observational cross-sectional study, male players, ("PRO") ("COL") level,...
To determine whether patients with hypothalamic hamartoma (HH) improve in their cognitive functioning after neurosurgical resection of HH and explore what variables correlate outcome.Thirty-two underwent preoperative postoperative neuropsychological testing. The age range was between 3.3 39.3 years (mean 12.2 years, SD 7.0). average time interval surgery testing 23.4 months (range 5.1-47.2 months). Tests administered varied on the basis patient's clinical condition.As a group, measures...
Currently, people at risk for dementia and their caregivers are confronted with confusing choices about what behavioral interventions most effective.The objective of this study is to determine which empirically supported impact the outcomes highly valued by patients mild cognitive impairment partners.This protocol describes a comparative effectiveness trial targeting 300 participants partners. The being conducted Mayo Clinic campuses in Arizona, Florida, Minnesota, University Washington...
Obstructive sleep apnea (SA) is common in older men and a contributor to negative cognitive, psychiatric, brain health outcomes. Little known about SA those who played contact sports are at increased risk of neurodegenerative disease(s) other neuropathologies associated with repetitive head impacts (RHI). In this study, we investigated the frequency diagnosed witnessed its contribution clinical symptoms tau pathology using PET imaging among male former college professional American football players.
Objective To examine the relationship between relatives' distress level and their ratings of impaired awareness for persons with traumatic brain injury (TBI). Design Outcome Measures Participants were 25 patients TBI, 16 probably dementia, 15 memory complaints but no dementia. completed Barrow Neurological Institute Screen Higher Cerebral Functions. Relatives all Patient Competency Rating Scale (Relative Form). also rated on a scale from 0 (no distress) to 10 (severe then patient's...
Primary objective: To explore pre-injury variables related to post-discharge psychosocial status and identify factors work driving outcomes.Methods procedures: Ninety-three brain-injured patients attended a holistic milieu-oriented neurorehabilitation program were contacted 1–7 years post-discharge.Experimental interventions: Questionnaire data addressing post-injury work, driving, income, marital living situation.Main outcomes results: 74.3% involved in competitive and/or school with 86.0%...
Efficient eye movements provide a physical foundation for proficient reading skills. We investigated the effect of in-school saccadic training on performance. In this cross-over design, study participants (n = 327, 165 males; mean age [SD]: 7 y 6 mo [1y 1 mo]) were randomized into treatment and control groups, who then underwent eighteen 20-minute sessions over 5 weeks using King-Devick Reading Acceleration Program Software. Pre- posttreatment assessments included fluency, comprehension,...
Abstract INTRODUCTION Tau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project. METHOD We compare flortaucipir PET measures 104 former professional players (PRO), 58 college football (COL), and 56 same‐age men without exposure to repetitive head impacts (RHI) or brain injury (unexposed [UE]); characterize their associations with RHI exposure; who did not meet...