A5006625551- Dementia and Cognitive Impairment Research
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Olfactory and Sensory Function Studies
- Mental Health and Psychiatry
- Aging and Gerontology Research
- Chronic Disease Management Strategies
- Neurobiology of Language and Bilingualism
- Parkinson's Disease Mechanisms and Treatments
- Analytical Chemistry and Chromatography
- Neurological Disease Mechanisms and Treatments
- Nicotinic Acetylcholine Receptors Study
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Phosphodiesterase function and regulation
- Prion Diseases and Protein Misfolding
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Reproductive biology and impacts on aquatic species
- Aging, Elder Care, and Social Issues
- Amino Acid Enzymes and Metabolism
Southern Illinois University School of Medicine
2004-2024
Cleveland Clinic
1998-2001
University of Minnesota
1995-2000
HealthPartners
1997-2000
Regions Hospital
1998-2000
Triangle
1997
National Institute of Environmental Health Sciences
1997
St. John Medical Center
1990-1995
<h3>Importance</h3> Neurofibrillary tangles composed of aggregated tau protein are one the neuropathological hallmarks Alzheimer disease (AD) and correlate with clinical severity. Monoclonal antibodies targeting may have potential to ameliorate AD progression by slowing or stopping spread and/or accumulation pathological tau. <h3>Objective</h3> To evaluate safety efficacy monoclonal anti-tau antibody semorinemab in prodromal mild AD. <h3>Design, Setting, Participants</h3> This phase 2...
Accumulation of tau pathology in Alzheimer disease (AD) correlates with cognitive decline. Anti-tau immunotherapies were proposed as potential interventions AD. While antibodies targeting N-terminal failed to demonstrate clinical efficacy prodromal-to-mild AD, their utility at other stages was not evaluated prior studies. Lauriet is a phase 2 study an anti-tau monoclonal antibody, semorinemab, patients mild-to-moderate
To investigate the reliability and validity of free-hand clock drawings, a frequently used measure constructional apraxia, in patients with Alzheimer's disease.Survey for purpose testing new scale.Memory Disorder Clinic at university-affiliated hospital Upper Midwest.Forty-six were diagnosed clinically probable dementia Alzheimer type after evaluation, 26 normal elderly controls research volunteers without history cognitive dysfunction.Neuropsychological tests, dementia-related scales,...
Purpose: To assess the potential of delivering nerve growth factor (NGF) to brain along olfactory neural pathway for treatment Alzheimer's disease. Methods: Recombinant human NGF (rhNGF) was given as nose drops anesthetized rats. The rhNGF concentrations in were determined by enzyme-linked immunosorbent assay (ELISA). Results: Following administration, reached within an hour, achieving a concentration 3400 pM bulb, 660–2200 other regions and, 240 and 180 hippocampus amygdala, respectively....
AbstractThe blood-brain barrier presents a major problem in the administration and testing of neurotropins as it prevents sufficient concentration these potential therapeutic agents from reaching target areas human brain. The olfactory neuroepithelium is only area body which an extension central nervous system comes into direct contact with environment. Following intranasal 125I-labeled nerve growth factor (125I-NGF), radiolabel appeared rapidly bulb other brain regions. Radiolabel...
To identify patients with pure hippocampal sclerosis (HS) as a cause of dementia, to determine whether they have had histories hypotension or hypoxia, and compare the clinical features HS control group AD without HS.In retrospective study, authors reviewed all 1771 cases received in their dementia brain bank from 1978 through 1996 those HS, defined severe degeneration gliosis CA1 sector subiculum formation absence other significant dementing disease such Alzheimer's changes. The included...
The purpose of this study was to examine if selecting a sperm population with improved motion characteristics before freezing reduces the deleterious effects cryopreservation. Semen specimens from 15 normal donors were divided into two equal aliquots. first aliquot received no treatment (control), and second processed by swim-up washed preparation select better motility (swim-up). Both aliquots cryopreserved liquid nitrogen vapour method. Percentage evaluated computer-assisted semen...
• A double-blind, placebo-controlled pilot study was conducted to evaluate the safety and efficacy of treatment patients with Alzheimer's disease using monosialoganglioside GM-1, a neurotrophic factor. Of 46 enrolled, 42 completed all requirements. Nineteen received 100 mg GM-1 by daily intramuscular injection for 12 weeks. Twenty-three placebo. Case evaluations were done at baseline, week 12, 24 included both cognitive psychosocial scales. Study results suggested that safe, yet offered no...
The performances of the uncertain/mild cognitive impairment (MCI) patients on Alzheimer Disease Assessment Scale-Cognitive (ADAS-Cog) subscale were compared with those normal controls, disease CDR 0.5, and 1.0. Uncertain/MCI group was significantly different from controls 0.5 or 1.0 groups ADAS-Cog except a few non-memory subtests. Age correlated total error score in group, but there no significant correlation between age scores patient groups. Education not any group. Regardless educational...
The NINCDS-ADRDA criteria for the clinical diagnosis of probable Alzheimer disease (AD) state that "gait disturbances at onset or very early in course illness make uncertain unlikely," yet there have been few studies documenting validity statement. We therefore reviewed all cases pure autopsy-proven AD Ramsey Brain Bank to determine how frequently an abnormal gait was noted time presentation. Any reported disturbance considered gait. Only which medical records were available patient's...
The NINCDS-ADRDA criteria for the clinical diagnosis of probable Alzheimer disease (AD) state that “gait disturbances at onset or very early in course illness make uncertain unlikely,‘’ yet there have been few studies documenting validity statement. We therefore reviewed all cases pure autopsy-proven AD Ramsey Brain Bank to determine how frequently an abnormal gait was noted time presentation. Any reported disturbance considered gait. Only which medical records were available patient's...
Abstract Background The Southern Illinois University Longitudinal Cognitive Aging Study (SIU LCAS) is a community‐based, longitudinal cohort study initiated in 1984. LCAS was initially designed to improve the sensitivity of neuropsychological testing diagnose mild cognitive impairment (MCI) and dementia individuals residing central southern Illinois. Method Participants are recruited from community via newspaper advertisement, word‐of‐mouth, presentations. Individuals with family history...
Abstract Background The original Alzheimer’s Disease Assessment Scale – Cognitive Subscale (oADAS) is one of the most common measures cognition used in clinical trials dementia (AD). Despite this, oADAS has faced criticism for lacking sensitivity to Mild Impairment (MCI), potentially due ceiling effects certain subsets. Many attempts have been made improve MCI by including additional subtests. We previously exploratory factor analysis (EFA) on subtests from and a novel extended version ADAS...
Background Caregiver awareness of the abilities those they care for has much practical importance, especially from safety standpoint. Objectives To determine whether caregivers persons with memory impairment or Alzheimer's disease know if their are able to recall own drugs and medical histories. Method Persons prodromal probable AD (persons AD) who were visiting our school's neurology internal medicine clinics routine follow-up recruited on days appointments. Sixty-four caregiver-person...
We used principal component analysis (PCA) to examine the structure of a neuropsychological test battery administered 943 cognitively-normal adults enrolled in Southern Illinois University (SIU) Longitudinal Cognitive Aging Study (LCAS). Four components explaining most variance (63.9%) dataset were identified: speed/cognitive flexibility, visuospatial skills, word-list learning/memory, and story memory. Regression analyses confirmed that increased age was associated with decreased scores...
Introduction: As promoted in the Best Practice Caregiving national database, Minds Motion (MiM) program is an evidence-based, multimodal activity focused on improving physical, emotional, and mental wellbeing of older adults with cognitive impairment their caregivers. We describe herein how we translated MIM principles into general practice. Methods: Our consisted 20 unique sessions a twice per month schedule, each featuring different theme based holiday, activity, or common past experience....