A5101954090- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Wnt/β-catenin signaling in development and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Prostate Cancer Treatment and Research
- Memory and Neural Mechanisms
- Insect Resistance and Genetics
- Peroxisome Proliferator-Activated Receptors
- Epigenetics and DNA Methylation
- Circadian rhythm and melatonin
- Eicosanoids and Hypertension Pharmacology
- Receptor Mechanisms and Signaling
- Nuclear Receptors and Signaling
- Neuroendocrine regulation and behavior
- Clusterin in disease pathology
- Cancer-related gene regulation
- Mitochondrial Function and Pathology
- Entomopathogenic Microorganisms in Pest Control
- S100 Proteins and Annexins
- Neurotransmitter Receptor Influence on Behavior
- Pluripotent Stem Cells Research
- Bipolar Disorder and Treatment
- Insect-Plant Interactions and Control
- Alzheimer's disease research and treatments
China Pharmaceutical University
2012-2024
Beijing Radiation Center
2018
State Key Laboratory of Natural Medicine
2015-2017
East Carolina University
2008-2014
Hainan University
2014
Union Hospital
2008
Huazhong University of Science and Technology
2008
Biological Control of Insects Research Laboratory
1993
Agricultural Research Service
1993
Central China Normal University
1993
Abstract Objectives This study was conducted to evaluate the effects of exposure pioglitazone, a peroxisome proliferator-activated receptor agonist, on cognitive impairment induced by scopolamine, muscarinic antagonist, in mice. Methods Pioglitazone (9 mg/kg, 18 mg/kg) orally administered for 9 days at 30 min before intraperitoneal injection with scopolamine (0.8 i.p.). Cognitive function evaluated passive avoidance test and Morris water maze 10th day after treatment. Changes cholinergic...
Mechanical wounding or treatment with exogenous jasmonates (JA) induces differentiation of the laticifer in Hevea brasiliensis. JA is a key signal for latex biosynthesis and response rubber tree. Identification JAZ (jasmonate ZIM-domain) family proteins that repress responses has facilitated rapid progress understanding how this lipid-derived hormone controls gene expression related physiological processes plants. In work, full-length cDNAs six genes were cloned from H. brasiliensis (termed...
Studies have suggested that the nucleus accumbens (NAc) is implicated in pathophysiology of major depression; however, regulatory strategy targets NAc to achieve an exclusive and outstanding anti-depression benefit has not been elucidated. Here, we identified a specific reduction cyclic adenosine monophosphate (cAMP) subset dopamine D1 receptor medium spiny neurons (D1-MSNs) promoted stress susceptibility, while stimulation cAMP production D1-MSNs efficiently rescued depression-like...
Objective: The experiment aimed to find out the effectiveness of Zileuton, a 5-LOX inhibitor on depressive behavior and neuroinflammation in vivo.
 Method: Male ICR mice (25-30g) randomly distributed Veh+Veh, CRS+Vehicle, CRS+ZIL50, CRS+ZIL100. Zileuton was orally given treatment groups for 21 days after 3 weeks stress induce CRS model. Starting from day 1, model, were immobilized 8 hr/day consecutive stress. After completing drug administration, subjected behavioral tests, then...
Objective To study tissue engineered heart valve(TEHV)established hy basic fibroblast growth factor(bFGF)and mesenchymal stem cells(MSCs)and expression of lysyl oxidase(LOX) in TEHV.Methods MSCs were isolated,cultured and purified by using adherent culture.The third generation seeded onto decellularized aortic valve leaflet scaffold.In group A,TEHVs cutlured with DMEM media containing 10 μg/L bFGF.In B,TEHVs only.In C,TEHVs established myofibroblasts as seed cells.All groups cultured vitro...
During early mammalian embryonic development, different epigenetic mechanisms undergo dramatic changes; yet how these interconnected layers function together to coordinate expression of the genetic code in a spatiotemporal manner remains unknown. Here, we describe time-resolved study hierarchy marks and events, which used model transcriptional programs that cannot be understood by investigating steady state. We found that, following fertilization, re-establishment accessible chromatin with...
Abstract Generalization formation and extinction of aversion are associated with affective disorders, but little is known about underlying mechanisms. Here, we established a novel procedure for induction visual by dynamic stripe images on digital screens in mice. We found that decreased activity medial septum (MS) cholinergic neurons led to generalization loss, didn’t affect its extinction. identified new projection from MS habenula (MHb), inhibiting MS→MHb circuit disrupts formation, while...