A5103139896- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Connexins and lens biology
- Corneal surgery and disorders
- Ferroptosis and cancer prognosis
- Advanced Glycation End Products research
- Retinoids in leukemia and cellular processes
- Connective Tissue Growth Factor Research
- Ion Transport and Channel Regulation
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Pancreatic function and diabetes
- Nitric Oxide and Endothelin Effects
- Erythrocyte Function and Pathophysiology
- Phagocytosis and Immune Regulation
- Apelin-related biomedical research
- Fibroblast Growth Factor Research
- Nerve injury and regeneration
- Natural Antidiabetic Agents Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Medical Imaging Techniques and Applications
- Angiogenesis and VEGF in Cancer
Xinjiang University
2025
Harbin Medical University
2014-2024
First Affiliated Hospital of Harbin Medical University
2014-2024
Shandong First Medical University
2022-2024
Shandong Eye Hospital
2022-2024
Zhongshan Hospital
2024
Fudan University
2024
Nanjing University of Chinese Medicine
2020
Jesse Brown VA Medical Center
2016
University of Illinois Chicago
2016
During storage, red blood cells (RBCs) lose their membrane stability, leading to haemolysis and microparticle (MP) formation. The use of RBCs stored for more than 28 days has been associated with an increased incidence deep vein thrombosis. However, the exact mechanism by which coagulation activation is enhanced in still unknown.To investigate relevant potential procoagulant activities MPs study relative factors initiating on RBCs.MPs were isolated from plasma RBC units...
The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health problem and novel therapeutic strategies are required to prevent treat T2DM. It has been demonstrated that resveratrol (RSV) may T2DM by targeting Sirtuin 1 (SIRT1), indicating SIRT1 be target for prevention. In the present study, rat model was established administering high fat diet streptozotocin (STZ) injections. Measurements blood glucose insulin confirmed successful establishment model. RSV used rats with...
l-Asparaginases of bacterial origin are a mainstay acute lymphoblastic leukemia treatment. The mechanism action these enzyme drugs is associated with their capacity to deplete the amino acid l-asparagine from blood. However, clinical use l-asparaginases complicated by dual l-asparaginase and l-glutaminase activities. latter, even though representing only ∼10% overall activity, partially responsible for observed toxic side effects. Hence, devoid activity hold potential as safer drugs....
Retinol-binding protein 4 (RBP4) is a newly discovered adipokine, which reported to be correlated with insulin resistance (IR) and type 2 diabetes (T2DM). The aim of this study was evaluate the influence menopausal status on RBP4 concentration investigate serum IR prevalence T2DM in postmenopausal women. We conducted cross-sectional enrolled 34 healthy premenopausal women, 41 women 37 T2DM. Serum measured by an enzyme-linked immunosorbent assay. Anthropometric parameters, plasma glucose, sex...
The aim of this study was to determine the effects simvastatin and atorvastatin on markers oxidative stress in patients with type 2 diabetes mellitus (T2DM). population consisted 151 T2DM 147 control individuals. were treated 40 mg per day or 10 day. Waist circumference, body mass index, blood pressure, glucose insulin values obtained; fasting serum lipids, malondialdehyde, nitric oxide, glutathione peroxidase superoxide dismutase activity determined before after 12 weeks treatment. Statin...
The mechanisms for thrombosis in diabetic retinopathy (DR) are complex and need to be further elucidated. purpose of this study was test phosphatidylserine (PS) exposure on microparticles (MPs) MP-origin cells from the circulation analyze cell-/MP-associated procoagulant activity (PCA) DR patients.PS-positive MPs healthy controls (n = 20) patients 60) were analyzed by flow cytometry confocal microscopy. Clotting time purified coagulation assays used measure PCA.PS platelets monocytes higher...
The pathogenesis of hypercoagulability in retinal vein occlusion (RVO) is largely unknown. Whether the exposure phosphatidylserine (PS) and microparticle (MPs) release will affect procoagulant activity (PCA) RVO needs to be investigated. Objectives . To evaluate PS expression, circulating MPs, corresponding PCA patients. Twenty‐five patients were compared with 25 controls. PS‐positive cells detected by flow cytometry. Cell‐specific MPs measured lactadherin for relevant CD antibody. We...
Type 2 diabetes is a chronic inflammatory disease. Autophagy, the dynamic process of lysosomal degradation damaged organelles and proteins, may protect β‑cells from destruction by inflammation in type diabetes. The present study investigated role autophagy, endoplasmic reticulum (ER) stress INS‑1 cells were incubated with lipopolysaccharide. chemical chaperone 4‑phenylbutyric acid was used to inhibit ER stress, 3‑methyadenine (3‑MA) autophagy. Apoptosis detected flow cytometry cell...