A5100367849- Weed Control and Herbicide Applications
- Food composition and properties
- Meat and Animal Product Quality
- Nutrition, Health and Food Behavior
- RNA modifications and cancer
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Food Waste Reduction and Sustainability
- Plant Disease Management Techniques
- Food Quality and Safety Studies
- GABA and Rice Research
- Food Safety and Hygiene
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Soybean genetics and cultivation
- Botany, Ecology, and Taxonomy Studies
- Advanced Glycation End Products research
- Mediterranean and Iberian flora and fauna
- Botany and Plant Ecology Studies
- Agronomic Practices and Intercropping Systems
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Plant Pathogens and Resistance
- Protein purification and stability
- Food Industry and Aquatic Biology
Pennsylvania State University
2024
Thomas Jefferson University
2024
Dankook University
2024
Old Dominion University
2021-2023
Global Alliance for Improved Nutrition
2022
National Institute of Allergy and Infectious Diseases
2019
Iowa State University
2006-2018
Korea University
2018
McGill University Health Centre
2017
Western Sydney University
2015-2016
Wnt family members are critical to many developmental processes, and components of the signaling pathway have been linked tumorigenesis in familial sporadic colon carcinomas. Here we report identification two genes, WISP-1 WISP-2, that up-regulated mouse mammary epithelial cell line C57MG transformed by Wnt-1, but not Wnt-4. Together with a third related gene, WISP-3, these proteins define subfamily connective tissue growth factor family. Two distinct systems demonstrated WISP induction be...
Cancer genomes maintain a complex array of somatic alterations required for maintenance and progression the disease, posing challenge to identify driver genes among this genetic disorder. Toward end, we mapped regions recurrent amplification in large collection (n=392) primary human cancers selected 620 whose expression is elevated tumors. An RNAi loss-of-function screen targeting these across panel 32 cancer cell lines identified potential genes. Subsequent functional assays SHMT2, key...
The KEAP1/Nrf2 pathway senses and responds to changes in intracellular oxidative stress. Mutations that result constitutive activation of Nrf2 are present several human tumors, especially non-small cell lung cancer. Therefore, compounds inhibit activity might be beneficial treating patients whose tumors show this pathway. Recent reports suggest the natural product brusatol can potently selectively activity, resulting cytotoxicity, effectively combined with chemotherapeutic agents. Here, we...
Abstract: Porcine reproductive and respiratory syndrome (PRRS), caused by the PRRS virus (PRRSV), is an economically devastating disease, causing daily losses of approximately $3 million to US pork industry. Current vaccines have failed completely prevent outbreaks. Recently, we shown that poly(lactic- co -glycolic) acid (PLGA) nanoparticle-entrapped inactivated PRRSV vaccine (NP-KAg) induces a cross-protective immune response in pigs. To further improve its efficacy, NP-KAg formulation was...
This study examines the food safety beliefs of vendors and consumers in a mid-sized Nigerian city using data from in-depth interviews cognitive mapping techniques drawn ethnography. We examine vendors’ consumers’ perspectives on which foods are safe, not, why; place foodborne illness among other health concerns motivators choice; how salient is as concern for vendors. The main perceived causes unsafe were found to be chemicals insects; while bacterial illnesses widely mentioned cause...
Some transcription factors (TFs) can form liquid-liquid phase separated (LLPS) condensates. However, the functions of these TF condensates in 3D genome organization and gene regulation remain elusive. In response to methionine (met) starvation, budding yeast Met4 a few co-activators, including Met32, induce set genes involved met biosynthesis. Here, we show that endogenous Met32 co-localized puncta-like structures nuclei upon depletion. Recombinant mixed droplets with LLPS properties vitro ....
This paper uses detailed data from in-depth interviews with consumers (n = 47) and vendors 37) in three traditional markets Birnin Kebbi, Nigeria. We used observations those to examine how identify avoid or manage food safety risks whom they hold responsible trust when it comes ensuring safety. At the level of vendor, mentioned seeking "clean" "neat" stalls. Cleanliness was primarily related appearance stall, surroundings; reliance on trusted, known also noted. Food products themselves were...
In Brief Advanced glycation end products (AGEs) accumulate in diabetic wounds as a result of the glycosylation various proteins. Interaction AGEs with receptor for (RAGE) results an exaggerated inflammatory response and compromised collagen production. These changes lead to impaired wound healing. A soluble form RAGE (sRAGE) has been shown bind thereby blunt their pathogenetic effects. Using genetically C57BLks-db/db mice, authors applied sRAGE topically standardized full-thickness improve...
A number of cytotoxic pyrrolobenzodiazepine (PBD) monomers containing various disulfide-based prodrugs were evaluated for their ability to undergo activation (disulfide cleavage) in vitro the presence either glutathione (GSH) or cysteine (Cys). good correlation was observed between GSH stability and cytotoxicity toward tumor cell lines. The prodrug-containing compounds typically more potent against cells with relatively high intracellular levels (e.g., KPL-4 cells). Several antibody–drug...
본 연구는 유화형 소시지에 유자과피 분말을 각각 0.3%, 0.6% 및 0.9% 수준으로 첨가하여 제조한 다음 소시지의 품질특성에 미치는 영향을 비교하고자 실시하였다. pH값은 분말 첨가 소시지가 대조구에 비해 낮은 pH값을 나타내었고, 대조구와 0.3과 pH 값을 나타내었다. 명도와 적색도 값은 소시지와 유사한 대조구가 0.6%와 소시지보다 명도 현저하게 높았다. 황색도 높았고, 수준이 증가함에 따라 증가하였다. 지방산화도를 나타내는 TBARS는 저장 1일에는 첨가소시지간에 차이를 보이지 않았고, 20일 이후에는 지방산화도 잔존 아질산염 함량은 낮았고, 함량을 조직특성에서 단단함 정도를 경도는 경도 값도 응집성, 탄력성 점착성(뭉침성)은 이상에서, 함유한 소시지는 pH, 색도, 보였으며, 지방산화를 지연시키고 낮추는 기능성 육제품 생산이 가능하다고 사료된다. This study was carried out to investigate the effects of addition...
Some transcription factors (TFs) can form liquid-liquid phase separated (LLPS) condensates. However, the functions of these TF condensates in 3D genome organization and gene regulation remain elusive. In response to methionine (met) starvation, budding yeast Met4 a few co-activators, including Met32, induce set genes involved met biosynthesis. Here, we show that endogenous Met32 co-localized puncta-like structures nuclei upon depletion. Recombinant mixed droplets with LLPS properties vitro ....
Three experiments were performed to characterize the physiological responses of an Eastern United States shipper muskmelon ( Cucumis melo L. var. reticulatus ‘Athena’) harvested preripe (¼ slip) and during ripening (half-slip, full-slip) 1 μL·L −1 1-methylcyclopropene (1-MCP), a potent ethylene antagonist effective at significantly extending time required for climacteric fruit complete ripening. In first experiment, treated with 1-MCP (18 hour, 20 °C) before storage 15 °C. Softening ‘Athena’...
This study was carried out to investigate the effects of addition mugwort powder (0.7%, 1%, 2%) on quality characteristics emulsion-type sausages. The pH, color, TBARS, textural properties, minerals content and sensory evaluation were evaluated. pH values sausage containing significantly lower as compared control during 20 days storage, but there higher than those at 40 storage. L* a* control, b* in powder. TBARS 45 hardness control. Na Mg, Ca, Mn Fe contents 2% Sensory panels evaluated that...
An alternating tangential flow (ATF) perfusion-based transient gene expression (TGE) bioprocess has been developed using human embryonic kidney (HEK) 293 cells to produce H1-ss-np, a promising candidate for universal influenza vaccine. Two major adjustments were taken improve the process: (1) eliminate interference of microbubbles during transfection; and (2) utilize an ATF perfusion system prolonged culture period. As result, closed-operation 9-days TGE was developed. The showed continuous...
This study was carried out to investigate the effects of addition citron peel powder(OJ 0/0, 0.60/0, 0.9 %) on proximate composition, minerals, vitamin A, C content and fatty acid composition emulsion-type sausages. The moisture sausage containing 0.3% powder were significantly(P< 0.05) higher compared those for control. crude fat significantly( P< lower ash 0.9% A significantly(P < palmitic acid(CI6: 0) linoleic acid(CI8: 2) control, but palmitoleic I) lower. total saturated