Lulu Zhai

ORCID: 0000-0003-0839-7316
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About
Contact & Profiles
Research Areas
  • Plant Molecular Biology Research
  • Plant Gene Expression Analysis
  • Pancreatic and Hepatic Oncology Research
  • Plant Disease Resistance and Genetics
  • Plant Stress Responses and Tolerance
  • Photosynthetic Processes and Mechanisms
  • Cancer-related molecular mechanisms research
  • Agriculture, Soil, Plant Science
  • RNA modifications and cancer
  • Heat shock proteins research
  • Plant Genetic and Mutation Studies
  • Soybean genetics and cultivation
  • Pancreatitis Pathology and Treatment
  • Ferroptosis and cancer prognosis
  • Endoplasmic Reticulum Stress and Disease
  • Plant Reproductive Biology
  • Heavy metals in environment
  • Vitamin D Research Studies
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Plant tissue culture and regeneration
  • Cancer, Lipids, and Metabolism
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Protease and Inhibitor Mechanisms
  • Cancer survivorship and care
  • Radiomics and Machine Learning in Medical Imaging

University of Science and Technology of China
2022-2025

Jilin University
2017-2024

Renmin Hospital of Wuhan University
2020-2023

Nanjing Agricultural University
2012-2023

Wuhan University
2020-2023

Jilin Medical University
2023

Hefei University
2022

Hangzhou First People's Hospital
2017-2020

Zhejiang University
2019-2020

Anhui Medical University
2014-2018

MicroRNAs (miRNAs) are endogenous non-coding small RNAs that play vital regulatory roles in plant growth, development, and environmental stress responses. Cadmium (Cd) is a non-essential heavy metal highly toxic to living organisms. To date, number of conserved non-conserved miRNAs have been identified be involved response Cd some species. However, the miRNA-mediated gene networks responsive radish (Raphanus sativus L.) remain largely unexplored. dissect Cd-responsive their targets...

10.1093/jxb/ert240 article EN cc-by Journal of Experimental Botany 2013-09-07

Summary Colour change is an important event during fruit ripening in blueberry. It well known that miR156/ SPL s act as regulatory modules mediating anthocyanin biosynthesis and ethylene plays critical roles colour change, but the intrinsic connections between two pathways remain poorly understood. Previously, we demonstrated blueberry VcMIR156a/VcSPL12 affects accumulation of anthocyanins chlorophylls tomato Arabidopsis. In this study, first showed VcMIR156a overexpression led to enhanced...

10.1111/pbi.14193 article EN cc-by-nc-nd Plant Biotechnology Journal 2023-10-05

Radish (Raphanus sativus L.), is an important root vegetable crop worldwide. Glucosinolates in the fleshy taproot significantly affect flavor and nutritional quality of radish. However, little known about molecular mechanisms underlying glucosinolate metabolism radish taproots. The limited availability genomic information has greatly hindered functional analysis breeding radish.In this study, a high-throughput, large-scale RNA sequencing technology was employed to characterize de novo...

10.1186/1471-2164-14-836 article EN cc-by BMC Genomics 2013-11-27

Color change is an important event during fruit maturation in blueberry, usually depending on chlorophyll degradation and anthocyanin accumulation. MicroRNA156 (miR156)-SPL modules are group of regulatory hubs involved the regulation biosynthesis. However, little known regarding their roles blueberry or metabolism color change. In this study, a MIR156 gene (VcMIR156a) was experimentally identified (Vaccinium corymbosum). Overexpression VcMIR156a tomato (Solanum lycopersicum) enhanced...

10.1093/jxb/eraa327 article EN Journal of Experimental Botany 2020-07-14

microRNA166 (miR166) is a highly conserved family of miRNAs implicated in wide range cellular and physiological processes plants. miR166 generally comprises multiple members plants, which might exhibit functional redundancy specificity. The soybean consists 21 according to the miRBase database. However, evolutionary conservation diversification remain poorly understood.We identified five novel miR166s by data mining approach, thus enlarging size from 26 members. Phylogenetic analyses their...

10.1186/s12870-017-0983-9 article EN cc-by BMC Plant Biology 2017-01-31

MicroRNAs (miRNAs) play vital roles in the regulation of fruit development and ripening. Blueberry is an important small berry crop with economical nutritional value. However, nothing known about miRNAs their targets involved blueberry In this study, using high-throughput sequencing RNAs, 84 belonging to 28 families 16 novel were identified white (WF) blue (BF) libraries, which represent ripening onset progress, respectively. Among them, 41 shown be differentially expressed during...

10.3390/ijms18122767 article EN International Journal of Molecular Sciences 2017-12-19

Embryogenesis is an important component in the life cycle of most plant species. Due to difficulty embryo isolation, global gene expression involved embryogenesis, especially early events following fertilization are largely unknown radish. In this study, three cDNA libraries from ovules radish before and after were sequenced using Digital Gene Expression (DGE) tag profiling strategy. A total 5,777 differentially expressed transcripts detected based on pairwise comparison (0_DAP, 7_DAP...

10.1038/srep21652 article EN cc-by Scientific Reports 2016-02-23

Pancreatic cancer (PC) is one of the most fatal cancers with a very poor prognosis. Here, we found that N6-methyladenosine (m6A) RNA demethylase fat mass and obesity-related protein (FTO) promote growth, migration invasion PC. FTO expression level increased in human PC associated prognosis patients. Knockdown increases m6A methylation TFPI-2 mRNA cells, thereby increasing stability via reader YTHDF1, resulting up-regulation expression, inhibits proliferation, colony formation, sphere vitro,...

10.1080/15592294.2022.2061117 article EN Epigenetics 2022-04-11
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