Deep brain stimulation with a PINS device in Parkinson's disease: long-term follow-up

• DOI: 10.3760/cma.j.issn.1001-2346.2017.11.012
• Publication Date: 2017-11-28
• Authors: Huanguang Liu; Defeng Liu; Huimin Wang; Yin Jiang; Xin Zhang; Yang Anchao; Fangang Meng; Kai Zhang
• Keywords: Subthalamic Nucleus; Brain stimulation

Objective To evaluate the long-term safety and efficacy of subthalamic nucleus deep brain stimulation (STN-DBS) with a PINS stimulator in Parkinson's disease (PD).

Methods Fifty patients received device implantation from November 2009 to August 2012 at Neurosurgery Department Beijing Tiantan Hospital, Capital Medical University were retrospectively enrolled into this study. The effects on motor score, activities daily living, levodopa-equivalent dose, side analyzed for all 50 PD undergoing bilateral STN-DBS based Unified Disease Rating Scale (UPDRS). scores collected baseline two conditions (off medication) 6 months, 1, 2, 5 years follow-up absence or presence medication.

Results The followed up 5.0-7.5 years. At follow-up, our results showed significant decrease both living (P<0.01); dose decreased compared (P<0.01). In condition medication off, UPDRS Ⅲ by 71%, 69%, 62% 1 year, 2 years, respectively; improvement rates Ⅱ 62%, respectively. 31%, 37%, 35%, 27% There was no death intracranial hemorrhage Five suffered transient mental psychiatric disturbances. Two cases infection, case cerebrospinal fluid leakage, ptosis, dysphonia observed during follow-up. preoperative dyskinesia had including reported disappearance remaining following adjustment programming parameters.

Conclusion STN-DBS could significantly improve symptoms life quality patients, which demonstrated study.

Key words: Parkinson disease; Deep stimulation; Subthalamic