A5078583132- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Genetic Neurodegenerative Diseases
- Balance, Gait, and Falls Prevention
- Sleep and Wakefulness Research
Beijing Tian Tan Hospital
2021-2024
Capital Medical University
2021-2024
Sleep disturbances are highly prevalent in movement disorders, potentially due to the malfunctioning of basal ganglia structures. Pallidal deep brain stimulation (DBS) has been widely used for multiple disorders and reported improve sleep. We aimed investigate oscillatory pattern pallidum during sleep explore whether pallidal activities can be utilized differentiate stages, which could pave way sleep-aware adaptive DBS.We directly recorded over 500 h local field potentials from 39 subjects...
OBJECTIVE Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has demonstrated efficacy against multiple types dystonia, but only a few case reports and small-sample studies have investigated clinical utility STN-DBS for Meige syndrome, rare distressing form craniofacial dystonia. Furthermore, effects DBS on critical neuropsychological sequelae, such as depression anxiety, are rarely examined. In this study, authors therapeutic both motor psychiatric symptoms syndrome. METHODS The...
Background: Freezing of gait (FOG) is a common disabling symptom in Parkinson’s disease (PD). Cognitive impairment may contribute to FOG. Nevertheless, their correlations remain controversial. We aimed investigate cognitive differences between PD patients with and without FOG (nFOG), explore severity performance assess heterogeneity within the patients. Methods: Seventy-four (41 FOG, 33 nFOG) 32 healthy controls (HCs) were included. Comprehensive neuropsychological assessments testing...
Abstract The effect of subthalamic nucleus deep brain stimulation (STN-DBS) on balance function in patients with Parkinson’s disease (PD) and the potential outcome predictive factors remains unclear. We retrospectively included 261 PD who underwent STN-DBS finished 1-month follow-up (M1) assessment explorative set for identifying postoperative change predictors, 111 both M1 12-month (M12) validation verifying identified factors. Motor improvement were evaluated through UPDRS-III Berg scale...
Low-frequency oscillations (LFOs, 28 Hz) in the subthalamic nucleus(STN) are known to reflect cognitive conflict. However, it is unclear if LFOs mediate communication and functional interactions among regions implicated conflict processing, such as motor cortex (M1), premotor (PMC), superior parietal lobule (SPL). To investigate potential contribution of mediation, we recorded M1, PMC, SPL activities by right subdural electrocorticography (ECoG) simultaneously with bilateral STN local field...
Abstract Sleep disturbances profoundly affect the quality of life in individuals with neurological disorders. Closed-loop deep brain stimulation (DBS) holds promise for alleviating sleep symptoms, however, this technique necessitates automated stage decoding from intracranial signals. We leveraged overnight data 121 patients movement disorders (Parkinson’s disease, Essential Tremor, Dystonia, Huntington’s and Tourette’s syndrome) whom synchronized polysomnograms basal ganglia local field...
Abstract Aims Patients with Parkinson's disease (PD) have various motor difficulties, including standing up, gait initiation and freezing of gait. These abnormalities are associated cortico‐subthalamic dysfunction. We aimed to reveal the characteristics activity in PD patients during different statuses. Methods Potentials were recorded superior parietal lobule (SPL), primary cortex (M1), premotor (PMC), bilateral subthalamic nucleus (STN) 18 freely walking while sitting, standing, walking,...
Background: Electrode reconstruction for postoperative deep brain simulation (DBS) can be achieved manually using a surgical planning system such as Surgiplan, or in semi-automated manner software the Lead-DBS toolbox. However, accuracy of has not been thoroughly addressed. Methods: In our study, we compared DBS results and Surgiplan. We included 26 patients (21 with Parkinson’s disease 5 dystonia) who underwent subthalamic nucleus (STN)-DBS, reconstructed electrodes toolbox The electrode...
Postural instability/gait disturbance (PIGD) is very common in advanced Parkinson's disease, and associated with cognitive dysfunction. Research suggests that low frequency (5-12 Hz) subthalamic nucleus-deep brain stimulation (STN-DBS) could improve cognition patients disease (PD). However, the clinical effectiveness of PIGD has not been explored. This study was designed a double-blinded randomized cross-over manner, aimed to verify effect STN-DBS on patients. Twenty-nine were tested for at...
Sleep difficulties affect up to 98% of Parkinson's disease (PD) patients and are often not well treated. How globus pallidus internus (GPi)-DBS could help is less understood. We retrospectively analyzed sleep outcomes in 32 PD after GPi-DBS with a two-year follow-up. observed high heterogeneity response pallidal stimulation: 16 showed clinically meaningful improvement, 9 had minor changes, 7 experienced worsened quality, no overall significant change on the Disease Scale-2 (P = 0.19)....
Abstract Neuroscientific studies on the function of basal ganglia often examine behavioral performance patients with movement disorders, such as Parkinson’s disease (PD) and dystonia (DT), while simultaneously examining underlying electrophysiological activity during deep brain stimulation surgery. Nevertheless, to date, there have been no comparing cognitive PD DT In this study, we assessed memory Montreal Cognitive Assessment (MoCA) Mini-Mental State Examination (MMSE). We also tested...