A5100363985- Streptococcal Infections and Treatments
- Peptidase Inhibition and Analysis
- Cardiovascular Health and Risk Factors
- Gut microbiota and health
- Diet and metabolism studies
- Phytoestrogen effects and research
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Tryptophan and brain disorders
- Traditional Chinese Medicine Analysis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Radiomics and Machine Learning in Medical Imaging
- Traditional Chinese Medicine Studies
- Neonatal and Maternal Infections
- Intracranial Aneurysms: Treatment and Complications
- Toxin Mechanisms and Immunotoxins
- Cytokine Signaling Pathways and Interactions
- Pulmonary Hypertension Research and Treatments
- Seismic and Structural Analysis of Tall Buildings
- Breast Lesions and Carcinomas
- Inflammasome and immune disorders
- Osteoarthritis Treatment and Mechanisms
- Nutritional Studies and Diet
- Bone health and treatments
- Pharmacological Receptor Mechanisms and Effects
Henan University
2023-2025
Fudan University Shanghai Cancer Center
2016-2025
Shanghai Medical College of Fudan University
2016-2025
Xinjiang Agricultural University
2019-2024
Zhongda Hospital Southeast University
2019-2024
Southeast University
2019-2024
Qingdao University
2024
General Hospital of Shenyang Military Region
2020-2024
Hangzhou Normal University
2024
Yuhuangding Hospital
2024
To evaluate the effectiveness of Tai Chi in treatment knee osteoarthritis (OA) symptoms.We conducted a prospective, single-blind, randomized controlled trial 40 individuals with symptomatic tibiofemoral OA. Patients were randomly assigned to 60 minutes (10 modified forms from classic Yang style) or attention control (wellness education and stretching) twice weekly for 12 weeks. The primary outcome was Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) pain score at Secondary...
Manipulating the Kondo effect by quantum confinement has been achieved placing magnetic molecules on silicon-supported nanostructures. The resonance of individual manganese phthalocyanine (MnPc) adsorbed top Pb islands was studied scanning tunneling spectroscopy. Oscillating temperatures as a function film thickness were observed and attributed to formation thickness-dependent quantum-well states in host islands. present approach provides technologically feasible way for single spin...
Background: Accumulating evidence has shown that neuropsychiatric disorders are associated with gut microbiota through the gut-brain axis. However, effects of antidepressant treatment on rarely studied. Here, we investigated whether stress led to changes and fluoxetine plays a role in alteration. Methods: We depression model induced by chronic unpredicted mild (CUMS) restoration applying classic drug fluoxetine. Results: found low bacterial diversity, simpler network, increased abundance...
Depression and obesity have high concurrence within individuals, which may be explained by sharing the same risk factors, including disruption of intestinal microbiota.However, evidence that delineated causal connections is extremely scarce.Methods: Mice lacking fat mass-and obesity-associated gene (Fto) were generated.Fto-deficient wild-type control mice subjected to novel conditions with or without chronic unpredictable mild stress (CUMS) for 6 weeks.Some treated antibiotics via their...
Tumor genetic testing is indispensable in the management of primary and metastatic colorectal cancer (CRC), yet indications for genomics-guided precision medicine immunotherapy must be better understood defined.We prospectively sequenced tumors from 869 Chinese patients with CRC by a large panel evaluated clinical significance single-gene somatic mutations co-occurring events CRC, as well their functional effects tumorigenic mechanisms. We systematically assessed heterogeneity tumor immune...
Abstract BACKGROUND Pulmonary arterial hypertension (PAH) is a kind of pulmonary vascular lesion characterized by vasoconstriction and reshaping small arteries, ultimately resulting in increased artery pressure resistance, eventually leading to right ventricular failure death. This study was aimed construct platelet-derived growth factor BB (PDGF-BB)-induced rat smooth muscle cells (PASMCs) model conduct combined transcriptomic metabolomic analysis identify proliferation-related targets,...
Abstract Background The incidence of inflammatory bowel disease (IBD) is rising worldwide, but epidemiological data on children and adolescents are lacking. Understanding the global burden IBD among essential for standardization methodology treatment options. Methods This a cross-sectional study based aggregated data. We estimated prevalence in between 1990 2019 according to Global Burden Disease Study (GBD 2019). Age-standardized rates (ASRs) annual percentage changes (EAPCs) were used...
Abstract Background The role of socioeconomic status (SES) on hypertension prevalence and control has gotten much attention but with conflicting results. This paper aimed to quantify the association SES both rate in Nanjing, China. Methods A community-based cross-sectional study was conducted using multistage random sampling 60,283 adults aged more than 18 years between March 2017 June 2018. Hypertension defined as systolic blood pressure (BP) ≥ 140 mmHg and/or diastolic BP 90 or...
Objective: The aim of the study was to evaluate feasibility functional MR in predicting clinical response chemotherapy patients with colorectal liver metastases (CLM). Methods: A total 196 eligible were enrolled between August 2016 and January 2023. Functional performed at baseline after one cycle chemotherapy. diffusion kurtosis radiomic texture features extracted a signature model built using R package. initial 100 cases designated as training set, following 48 validation final...
Clear cell renal carcinoma (ccRCC) is corelated with tumor-associated material (TAM), coagulation system and adipocyte tissue, but the relationships between them have been inconsistent. Our study aimed to explore cut-off intervals of variables that are non-linearly related ccRCC pathological T stage for providing clues understand these discrepancies, effectively preoperative risk stratification.
Bifunctional conjugates targeting PD-L1/PARP7 were designed, synthesized, and evaluated for the first time. Compounds
Objective: The systemic inflammation index and body mass (BMI) are easily accessible markers that can predict mortality.However, the prognostic value of combined use these two remains unclear. goal this study was therefore toevaluate association with outcomes based on a large cohort patients gastric cancer. Methods: A total 2,542 consecutive undergoing radical surgery for or gastroesophageal junction adenocarcinomabetween 2009 2014 were included. Systemic quantified by preoperative...
Previous studies have demonstrated that sigma-1 receptor plays important roles in the induction phase of rodent neuropathic pain; however, whether it is involved bone cancer pain (BCP) and underlying mechanisms remain elusive. The aim this study was to examine potential role spinal development pain. Walker 256 mammary gland carcinoma cells were implanted into intramedullary space right tibia Sprague-Dawley rats induce ongoing cancer-related behaviors; our findings indicated that, on days 7,...
A retrospective analysis of diagnoses was performed in patients with phyllodes tumors the breast (PTB) who received preoperative core needle biopsy (CNB) and had surgery at Fudan University Shanghai Cancer Center from January 1, 2002 to April 2013. The resulting data allowed us compare accordance between CNB excision PTB evaluate accuracy diagnosis.Data 128 undergone were retrospectively analyzed. We reviewed medical history, clinical follow-up data, diagnostic data. test used sensitivity...