A5101470779- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Synthesis and Biological Evaluation
- Genomics, phytochemicals, and oxidative stress
- Heat shock proteins research
- Physiological and biochemical adaptations
- Urinary and Genital Oncology Studies
- Cervical Cancer and HPV Research
- Magnolia and Illicium research
- Microbial Applications in Construction Materials
- Synthetic Organic Chemistry Methods
- Pharmacological Effects of Natural Compounds
- Phytoestrogen effects and research
- Plant-derived Lignans Synthesis and Bioactivity
- Amino Acid Enzymes and Metabolism
- Ubiquitin and proteasome pathways
- Sulfur-Based Synthesis Techniques
- Emotion and Mood Recognition
- Lichen and fungal ecology
- Natural product bioactivities and synthesis
- Peptidase Inhibition and Analysis
- Drug Transport and Resistance Mechanisms
- Free Radicals and Antioxidants
- Medicinal Plants and Bioactive Compounds
- Traditional Chinese Medicine Studies
Qingdao Municipal Hospital
2024
Qingdao University
2024
Shanghai University of Traditional Chinese Medicine
2021-2024
Hangzhou Normal University
2014-2024
Nanchang University
2022-2023
Minzu University of China
2022
Guangdong Pharmaceutical University
2020
Yantai University
2011
Hefei University of Technology
2000
Institute of Economics
2000
Histone deacetylases (HDACs) inhibitors such as vorinostat (SAHA) has been used to treat hematologic malignancies (rather than solid tumors) and have found suppress the JAK/STAT, a critical signal pathway for antitumor immunity, while PARP7 inhibitor RBN-2397 could activate type I interferons (IFN-I) pathway, facilitating downstream effects STAT1 phosphorylation immune activation. To elucidate whether simultaneous inhibition of these two targets interfere with pathways, series...
β-Elemene is the major active ingredient of TCM anticancer drug elemene extracts. To further improve its antitumor activity and poor solubility, a polar HDACi pharmacophore was incorporated scaffold. Systematic SAR studies led to discovery compounds 27f 39f, which exhibited potent inhibitory against HDACs (HDAC1: IC50 = 22 9 nM; HDAC6: 8 14 nM, respectively). In cellular levels, 39f significantly inhibited cell proliferation five tumour lines (IC50: 0.79 - 4.42 µM). Preliminary mechanistic...
The role of heat shock proteins (HSPs) in tolerance has been demonstrated cultured cells and animal tissues, but rarely whole organisms because methodological difficulties associated with gene manipulation. By comparing HSP70 expression patterns among representative species reptiles birds, by determining the effect overexpression on embryonic development hatchling traits, we have identified amniote embryos. Consistent their thermal environment, high incubation temperatures tolerance, embryos...
Bifunctional conjugates targeting PD-L1/PARP7 were designed, synthesized, and evaluated for the first time. Compounds
Herein, we report the first access of β-elemene derivatives through SeO 2 -mediated oxidation reaction. Several new compounds were isolated such a one-step reaction, and their structures elucidated using various 2D-NMR techniques. This method provides easy to multiple oxidative in one single step represents modifications on cyclohexyl ring β-elemene. It is expected open up opportunity for future derivatization The obtained above showed better anti-proliferation activities than itself several...
A method for the separation and determination of honokiol magnolol in Magnolia officinalis its medicinal preparation is developed by capillary zone electrophoresis response surface methodology. The concentration borate, content organic modifier, applied voltage are selected as variables. optimized conditions (i.e., 16 mmol/L sodium tetraborate at pH 10.0, 11% methanol, 25 kV UV detection 210 nm) obtained successfully to analysis Huoxiang Zhengqi Liquid. Good achieved within 6 min. limits...
A series of novel N-alkyl-N-hydroxyl carboximates derived from β-elemene were fortuitously discovered. Most them showed more potent anti-proliferative activities than their lead compound (1). Notably, 11i exhibited significant inhibitory effects on the proliferation three lung cell lines (H1975, A549 and H460) several other tumour (H1299, U87MG, MV4-11, SU-DHL-2). Preliminary mechanistic studies revealed that could significantly induce apoptosis. Further in vivo study H460 xenograft mouse...
Abstract Purpose This study aimed to evaluate the clinical efficacy and safety of argon plasma coagulation (APC) therapy interferon in patients with grade I II vaginal intraepithelial neoplasia (VaIN). Methods A total 112 VaIN were diagnosed via colposcopy-induced biopsy classified into APC group ( n = 77) 35). Clinical data including age, grade, symptoms, historical or concomitant lower genital tract, indications for hysterectomy, pregnancy history, cytology, human papillomavirus (HPV)...
A new method for simultaneous determination of puerarin, daidzin, daidzein and genistein in Radix puerariae by ultra-high performance liquid chromatography was established. The target analytes were extracted from 70% ethylene glycol with the assistance ultrasonication, purified absorption N-propyl ethylenediamine (PSA), separated on a Supersil ODS column (4.6 mm × 250 2.5 μm). Gradient elution 12 min performed mobile phase 0.1% formic acid(A)-acetonitrile(B). temperature 25 °C flow rate 1...
<title>Abstract</title> <bold>Purpose</bold> This study aimed to evaluate the clinical efficacy and safety of argon plasma coagulation (APC) therapy interferon in patients with grade I II vaginal intraepithelial neoplasia (VaIN).<bold>Methods</bold> A total 112 VaIN were diagnosed via colposcopy-induced biopsy classified into APC group (n = 77) 35). Clinical data including age, grade, symptoms, historical or concomitant lower genital tract, indications for hysterectomy, pregnancy history,...
A new rapid and accurate method was developed for simultaneous determination of pyridoxine pyridoxal in ginkgo seeds, using ultra-performance liquid chromatography (UPLC) equipped with a fluorescence detector. Diluted hydrochloric acid solution used as the extracting solvent. For pretreatment extracts, zeolitic imidazolate framework material (ZIF-8) prepared characterized. An ODS-BP column (4.6 mm × 250 5 μm) separation. The conditions sample extraction, cleaning separation were optimized....
Depression is the most widely affecting of mental illnesses for public health concern.Although there are many treatments depression, barriers to diagnosis still exist.The intelligent relying on extraction biomarkers provides reliable indicators depression.This paper proposed a new method machine learning based vocal source features.The short-term and long-term features were combined classification evaluation.The contained four important selected by decision trees, random forest algorithm...
To observe the effect of Gansui Banxia Tang plus-minus and Gancao anti-drug combination on hepatic renal functions in malignant ascites rats to explore whether efficacy or toxicity associated with combination.The male wistar were randomly divided into a blank group, model furosemide removed Zhigancao Cugansui group. In addition normal feeding, every morning except for group rest was given drugs, control distilled water, volume is 10 mL x kg(-1). Administered five days, all fasted but water...
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