A5018717322- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Pharmacogenetics and Drug Metabolism
- Arsenic contamination and mitigation
- Ultrasonics and Acoustic Wave Propagation
- Water Quality Monitoring and Analysis
- Pregnancy and preeclampsia studies
- Statistical Methods in Clinical Trials
- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- Pregnancy and Medication Impact
- Plant Physiology and Cultivation Studies
- Gestational Diabetes Research and Management
- Traditional Chinese Medicine Analysis
- Heavy Metals in Plants
- Aluminum toxicity and tolerance in plants and animals
- Studies on Chitinases and Chitosanases
- Ultrasound Imaging and Elastography
- Hepatitis B Virus Studies
- Advanced Nanomaterials in Catalysis
- Educational Robotics and Engineering
- Traditional Chinese Medicine Studies
- Medical Malpractice and Liability Issues
- Extracellular vesicles in disease
- Antibiotics Pharmacokinetics and Efficacy
Shenzhen University
2019-2025
Center for Disease Control
2024
HKUST Shenzhen Research Institute
2022
Jiangsu Academy of Agricultural Sciences
2022
Shihezi University
2022
Vion Pharmaceuticals (United States)
2016-2018
Sunovion (United States)
2015-2018
Qingdao University
2018
Affiliated Hospital of Qingdao University
2018
Yunnan University
2018
Histone deacetylases (HDACs) inhibitors such as vorinostat (SAHA) has been used to treat hematologic malignancies (rather than solid tumors) and have found suppress the JAK/STAT, a critical signal pathway for antitumor immunity, while PARP7 inhibitor RBN-2397 could activate type I interferons (IFN-I) pathway, facilitating downstream effects STAT1 phosphorylation immune activation. To elucidate whether simultaneous inhibition of these two targets interfere with pathways, series...
Hydrogen sulfide (H2 S)-based mitochondrial bioenergetic intervention is an attractive therapeutic modality. However, its efficacy limited owing to metabolic plasticity, which allows tumors shift their phenotype between oxidative phosphorylation and glycolysis for energy compensation. To overcome this flexibility, a glycopolymer containing caged H2 S hydrogen peroxide O2 ) dual-donor (1-thio-β-D-glucose [thioglucose]) synthesized wrap glucose oxidase (GOx) complete depletion of tumorigenic...
Arsenic (As) is a toxic element, and long-term exposure to As can cause neurotoxicity. The bioactive natural compound Dictyophora polysaccharide (DIP) from edible plants has been reported reduce the toxicity of As. In this study, poisoning was simulated by feeding As-containing feed, followed proteomic analysis after one month DIP treatment. showed that 145, 276, 97 proteins were differentially expressed between As-treated rats control (As/Ctrl group), DIP-treated + (DIP As/As As/Ctrl...
Arsenic (As) is one of the most important toxic elements in natural environment. Currently, although assessment potential health risks chronic arsenic poisoning has received great attention, research on effects brain still limited. It been reported that dictyophora polysaccharide (DIP), a common bioactive compound found dietary plants, could reduce toxicity. Following behavioral research, comparative proteomics was performed to explore molecular mechanism toxicity hippocampi SD (Sprague...
Genetic heterogeneity poses a challenge to research and clinical translation of autism spectrum disorder (ASD). In this study, we conducted plasma proteomic metabolomic study children with ASD without risk genes (de novo mutation) controls explore the impact genetic on search for biomarkers ASD. terms profiles, groups carrying those not de mutation tended cluster overlap, integrating them yielded differentially expressed proteins differential metabolites that effectively distinguished from...
Abstract Single-atom nanozymes (SAzymes) hold significant potential for tumor catalytic therapy, but their effectiveness is often compromised by low efficiency within microenvironment. This mainly influenced key factors including hydrogen peroxide (H 2 O ) availability, acidity, and temperature. Simultaneous optimization of these presents a challenge therapy. In this study, we developed comprehensive strategy to refine single-atom kinetics enhancing therapy through dual-enzyme-driven cascade...
Natural products (NPs) are a promising source of anti-inflammatory molecules for the development drugs. Despite there being an abundance reports large numbers NPs having bioactivity in preliminary cell-based assays potential, their further optimization and exploration limited by lack comprehensive understanding effective scaffold structure or biological targets. To facilitate target-based studies NPs, details 665 reported to have activity were extracted from literature compiled into data set...
Dasotraline is a dopamine and norepinephrine reuptake inhibitor, the early clinical trials show slow absorption long elimination half-life. To investigate absorption, distribution, metabolism, excretion of dasotraline in humans, single dose [14C]-dasotraline was administered to eight healthy male adult volunteers. At 35 days, 90.7% dosed radioactivity recovered urine (68.3%) feces (22.4%). The major metabolic pathways involved were: (1) amine oxidation form oxime M41 sequential sulfation M42...
Abstract The ultrasonic Lamb wave testing (ULWT) has proven valuable in non-destructive (NDT) due to its high sensitivity and wide coverage. However, the classical post-processing algorithm, delay-and-sum (DAS) technique, suffers from notable artifacts inadequate accuracy inspection existence of reflection superposition, especially on composite materials. In this study, we proposed a novel correlation factor weighted DAS imaging algorithm based Long short-term memory-autoencoder (LSTM-AE),...