A5101607324- CRISPR and Genetic Engineering
- Chromosomal and Genetic Variations
- Heme Oxygenase-1 and Carbon Monoxide
- Paraquat toxicity studies and treatments
- RNA regulation and disease
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Plant responses to water stress
- Advanced MRI Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Sulfur Compounds in Biology
- Cardiac Fibrosis and Remodeling
- Mycobacterium research and diagnosis
- Hippo pathway signaling and YAP/TAZ
- Extracellular vesicles in disease
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Pulmonary Hypertension Research and Treatments
- Medical Imaging Techniques and Applications
- Cardiac Ischemia and Reperfusion
Agricultural Genomics Institute at Shenzhen
2022-2025
Chinese Academy of Agricultural Sciences
2022-2025
Ministry of Agriculture and Rural Affairs
2023-2025
Guiyang Medical University
2020-2025
Wenzhou Medical University
2019-2024
First Affiliated Hospital of Wenzhou Medical University
2019-2024
Affiliated Hospital of Guizhou Medical University
2022-2024
Mudanjiang Medical University
2024
Huazhong Agricultural University
2018-2023
Shandong Academy of Sciences
2021
Autophagy is a self-renewal mechanism that maintains homeostasis and can promote tissue regeneration by regulating inflammation, reducing oxidative stress promoting cell differentiation. The interaction between biomaterials cells significantly affects biomaterial-tissue integration regeneration. In recent years, it has been found affect various processes related to autophagy. utilization of in controlled environment become prominent approach for enhancing the capabilities. This involves...
Objectives Bipolar disorder ( BD ) is a mental characterized by periods of elevated mood and depression. Many individuals with are initially misdiagnosed treated for unipolar depression UD ). In this study, we report direct comparisons between medication‐free those in terms the neurometabolites anterior cingulate cortex ACC ), medial prefrontal mPFC parietal PC posterior PCC brain. Methods Participants included patients or , matched healthy controls. All were depressive state had similar...
Introduction Myocardial ischemia-reperfusion injury (MIRI) is a prevalent complication in patients with myocardial infarction. The pathological mechanism of MIRI remains elusive. Ferroptosis plays critical role MIRI. This study aimed to investigate the spermidine/spermine N1-acetyltransferase 1 (Sat1) by regulation ferroptosis. Methods Rats and H9C2 cells were used perform model. extent damage associated changes evaluated. Protein expression was detected western blot. Then we observed...
Summary Anthocyanin biosynthesis and accumulation determines the colour of tuber flesh in potato ( Solanum tuberosum ) influences nutritional quality. However, regulatory mechanism behind anthocyanin remains unclear. In this study, we identified Pigmented Pf locus through a genome‐wide association study using 135 diploid landraces. Genome editing two tandem R2R3 MYB transcription factor genes, StMYB200 StMYB210 , within demonstrated that both genes are involved flesh. Molecular biochemical...
Exosomes secreted by mesenchymal stem cells (MSCs) have been considered as a novel biological therapy for myocardial ischemia/reperfusion injury (MIRI). However, the underlying mechanism of exosomes has not completely established, especially in early stage MIRI. In this study, we primarily investigated protective effect on MIRI from both vitro and ex vivo perspectives. Bioinformatic analysis was conducted to identify exosomal miRNA associated with protection, Genes proteins related...
Mitophagy is a vital biological process playing central roles in the regulation of metabolic activity and quality control mitochondria. The presented dual-color fluorescent probes to directly monitor mitophagy were based on optical response pH change during mitophagy, but fluctuation may lead interference. To overcome this, herein, two (G-Mito, R-Lyso) rationally designed visualize manner, relying Förster resonance energy transfer (FRET) for first time. Green emissive G-Mito targeted...
Acute lung injury (ALI) is the primary cause of death among patients with acute paraquat (PQ) poisoning, whereby peroxidative damage an important mechanism underlying PQ-induced injury. There a lack effective interventional drugs for PQ poisoning. Oxaloacetic acid (OAA) participates in multiple vivo metabolic processes, it facilitates clearance reactive oxygen species (ROS) and improves mitochondrial function. The study aimed to assess protective effects OAA on ALI elucidate molecular...
Dimethyl fumarate (DMF) is an approved drug used in the treatment of multiple sclerosis (MS) and psoriasis therapy. Multiple studies have demonstrated other pharmacological activities DMF such as anti-cancer agent. In particular, shown that can modulate NRF2/HO1/NQO1 antioxidant signal pathway inactivate NF-κB to suppress growth colon breast cancer cells, induce cell death. this study, we aimed evaluate anti-tumor pancreatic (PC) focusing on death predominant mechanism response. We showed...
White matter (WM) neuroimaging studies have shown varied findings at different stages of schizophrenia (SZ). Understanding these variations may elucidate distinct markers genetic vulnerability and conversion to psychosis. To examine the similarities differences in WM connectivity between those at-risk for early SZ, a cross-sectional diffusion tensor imaging study 48 individuals diagnosed with first-episode SZ (FE-SZ), 37 nonpsychotic high risk (GHR-SZ), 67 healthy controls (HC) was...
HCC is a common cancer type in the world. Here, we found WZ35, novel derivative of curcumin, could notably suppress cell growth<italic>via</italic>inhibiting YAP controlled autophagy, highlighting potent anti-tumor activity WZ35 liver therapy.
Previous findings suggest that the Papez Circuit may have a role in major depressive disorders. We used atlas-based tract-specific quantification analysis and voxel-based to examine integrity of white matter tracts involved mood regulation (including Circuit). Diffusion tensor imaging acquired from 35 first-episode, treatment-naive adults with disorders 34 healthy adult controls were compared. Our statistical approach compared structural 11 between disorder controls, as well illness duration...
Background Previous studies proved that pyrin domain-containing protein 3 (NLRP3)-induced pyroptosis plays an important role in Myocardial ischemia-reperfusion injury (MIRI). Insulin can inhibit the activation of NLRP3 inflammasome, although exact mechanism remains unclear. The aim this study was to determine whether insulin reduces NLRP3-induced by regulating pyruvate dehydrogenase E1alpha subunit (PDHA1) dephosphorylation during MIRI. Methods Rat hearts were subject 30 min global ischemia...
Acute lung injury (ALI) induced by paraquat (PQ) progresses rapidly, leading to high mortality; however, there is no specific antidote. Our limited knowledge of the pathogenic toxicological mechanisms PQ has hindered development treatments against exposure.Pyroptosis a form programmed cell death recently identified as novel molecular mechanism adopted chemotherapeutic drugs for cancer therapy. However, involvement pyroptosis in PQ-induced not been reported. Therefore, we investigated effects...
Heart failure is a health burden responsible for high morbidity and mortality worldwide, dilated cardiomyopathy (DCM) one of the most common causes heart failure. DCM disease muscle characterized by enlargement dilation at least ventricle alongside impaired contractility with left ventricular ejection fraction < 40%. It also associated abnormalities in cytoskeletal proteins, mitochondrial ATP transporter, microvasculature, fibrosis. However, pathogenesis potential biomarkers remain to be...
Inventory monitoring in homes, factories, and retail stores relies on maintaining data despite objects being swapped, added, removed, or moved. We introduce Lifelong LERF, a method that allows mobile robot with minimal compute to jointly optimize dense language geometric representation of its surroundings. LERF maintains this over time by detecting semantic changes selectively updating these regions the environment, avoiding need exhaustively remap. Human users can query inventory providing...