A5100454208- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- Advanced X-ray and CT Imaging
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Retinopathy of Prematurity Studies
- CNS Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Retinoids in leukemia and cellular processes
- Boron Compounds in Chemistry
- Neonatal and fetal brain pathology
- Dental materials and restorations
- Endometrial and Cervical Cancer Treatments
- Amino Acid Enzymes and Metabolism
- Dental Research and COVID-19
- Head and Neck Surgical Oncology
- MRI in cancer diagnosis
- Protease and Inhibitor Mechanisms
- Fetal and Pediatric Neurological Disorders
- Cancer-related molecular mechanisms research
Shandong Tumor Hospital
2016-2025
Shandong First Medical University
2016-2025
Tianjin Medical University
2023
Tianjin Stomatological Hospital
2023
University of Jinan
2019-2020
Shandong University
2019
China-Japan Friendship Hospital
2018
University of Macau
2018
Suzhou Municipal Hospital
2018
Yale University
2017
White matter (WM) neuroimaging studies have shown varied findings at different stages of schizophrenia (SZ). Understanding these variations may elucidate distinct markers genetic vulnerability and conversion to psychosis. To examine the similarities differences in WM connectivity between those at-risk for early SZ, a cross-sectional diffusion tensor imaging study 48 individuals diagnosed with first-episode SZ (FE-SZ), 37 nonpsychotic high risk (GHR-SZ), 67 healthy controls (HC) was...
Site-specific conjugation of small molecules to antibody is a promising strategy for generation antibody-drug conjugates. In this report, we describe the successful synthesis novel bifunctional molecule, 6-(azidomethyl)-2-pyridinecarboxyaldehyde (6-AM-2-PCA), which was used peptides and antibodies. We demonstrated that 6-AM-2-PCA selectively reacted with N-terminal amino groups addition, azide group enabled copper-free click chemistry coupling dibenzocyclooctyne-containing reagents....
Modification of the alpha-carbamate substituent isoxazoline GPIIb/IIIa (alphaIIb beta3) antagonist DMP 754 (7) led to a series alpha-sulfonamide and alpha-sulfamide diaminopropionate isoxazolinylacetamides which were found be potent inhibitors in vitro platelet aggregation. Aryl- heteroaryl-alpha-sulfonamide groups, conjunction with (5R)-isoxazoline (2S)-diaminopropionate stereochemistry, impart pronounced duration antiplatelet effect dogs, potentially due high affinity for unactivated...
C-X-C motif chemokine receptor 4 (CXCR4) is an attractive target for the diagnosis and treatment of cancers. Here, we aimed to develop a new CXCR4-targeted PET tracer, investigate translational potential noninvasive imaging CXCR4 expression in various cancer entities through preclinical pilot clinical studies.
Given the variability in effectiveness of immune checkpoint blocking therapy among patients and tumor types, development noninvasive methods for longitudinal assessment cell function early response is crucial precision immunotherapy. CD137 (4-1BB), a marker activated T cells, plays significant role However, its potential as an imaging biomarker cells microenvironment has not been explored. This study introduces bicyclic peptide-based probe that targets PET tumor-infiltrating cells.
With the popularization of digital technology and exposure traditional technology’s defects, computer-aided design manufacturing (CAD/CAM) has been widely used in field dentistry. And accuracy scanning system determines ultimate prosthesis, which is a very important part CAD/CAM, so we decided to evaluate intraoral extraoral scanners. In this study, selected sphere model as object obtained final result through data analysis 3D fitting. terms trueness precision, scanner SHINING was...
The objective of this study was to investigate the effect and mechanism long noncoding RNA (lncRNA) on head neck squamous cell carcinoma (HNSCC).RNA extracted from HNSCC tissue adjacent tissues sequenced. Differentially expressed lncRNA microRNA (miRNA) were screened. Quantitative real-time polymerase chain reaction used compare expression target between human oral keratinocyte (HOK) cancer lines. LAMB1-210 in SCC-4 CAL-27 cells downregulated by transfecting short hairpin (shRNA). Methyl...
<p>Fig. S8. HSP2 and CycT do not affect iron metabolism hypoxia induction of HIF1�. (A) Iron stain did detect any difference between control treated tumor tissues. Shown are montages, 10X, 40X images control, CycT-treated tissue sections stained with Stain. The blue rectangles in 10X the regions shown images, respectively. Scale bar: montage, 1 mm for controls 500 µm tissues; 200 µm, 50 µm. (B) Representative IHC H1299 NSCLC graphs showing levels transferrin receptor TFRC HSP2,...
Objective To study the reliability of 99Tcm-(hydrazinonicotinamide (HYNIC)-BMS-200261)(tricine)(trisodium triphenylphosphine-3, 3′, 3″-trisulfonate (TPPTS)) as a radiotracer for protease activated receptor-1 (PAR-1) expression in breast cancer. Methods Fifteen nude mice bearing MDA-MB-435, MDA-MB-231 and MCF-7 human cancer xenografts (5 each cell line) with different PAR-1 were used 99Tcm-(HYNIC-BMS-200261)(tricine)(TPPTS) γ imaging, tumor/non-tumor (T/NT) ratios obtained region...