A5078816337- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Receptor Mechanisms and Signaling
- Lung Cancer Treatments and Mutations
- Neurotransmitter Receptor Influence on Behavior
- Advanced Fluorescence Microscopy Techniques
- Neural dynamics and brain function
- Cell Image Analysis Techniques
- Memory and Neural Mechanisms
- Cancer Genomics and Diagnostics
- Circadian rhythm and melatonin
- Stress Responses and Cortisol
- Adipokines, Inflammation, and Metabolic Diseases
- Multiple and Secondary Primary Cancers
- Single-cell and spatial transcriptomics
- Medical Imaging Techniques and Applications
- Sleep and Wakefulness Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
Columbia University Irving Medical Center
2023-2025
Sir Run Run Shaw Hospital
2024
Columbia University
2021-2024
Zhejiang University
2017-2024
Stanford University
2015-2023
Peking University
2021-2023
National Institute on Drug Abuse
2018-2022
Liaoning Cancer Hospital & Institute
2021
Stanford Cancer Institute
2019
Cornell University
2019
Flipping behavior under threat Could it be that the brain in a state of emergency or intense operates fundamentally different way? Seo et al. found mice paused when serotonin neurons were transiently stimulated low- medium-threat environments, but this same neural population was high-threat tried to escape. Recordings from these indicated movement-related tuning flipped between environments. Neural activity decreased movement initiated low-threat environments increased Science , issue p. 538
We recently developed a mouse model of appetitive operant aggression and reported that adult male outbred CD-1 mice lever-press for the opportunity to attack subordinate relapse seeking during abstinence. Here we studied role nucleus accumbens (NAc) dopamine receptor (Drd)1- Drd2-expressing neurons in self-administration seeking. trained self-administer intruders (9 d, 12 trials/d) tested them on abstinence Day 1. used immunohistochemistry <i>in situ</i> hybridization measure neuronal...
Abstract Mapping immediate early gene (IEG) expression across intact mouse brains allows for unbiased identification of brain-wide activity patterns underlying complex behaviors. Accurate registration sample to a common anatomic reference is critical precise assignment IEG-positive (“active”) neurons known brain regions interest (ROIs). While existing automated voxel-based methods provide high-throughput solution, they require substantial computing power, can be difficult implement and fail...
Studies using rodent models have shown that relapse to drug or food seeking increases progressively during abstinence, a behavioral phenomenon termed “incubation of craving.” Mechanistic studies incubation craving focused on specific neurobiological targets within preselected brain areas. Recent methodological advances in whole-brain immunohistochemistry, clearing, and imaging now allow unbiased brain-wide cellular resolution mapping regions circuits engaged learned behaviors. However, these...
Salivary gland epithelial cells (SGEC) release several cytokines that play important roles in the inflammatory process. In this study, we examined whether capsaicin can modulate cytokine SGEC. After were stimulated with polyinosinic-polycytidylic acid [poly(I:C)] or lipopolysaccharide (LPS), mRNA transcript and protein levels detected by reverse-transcriptase-polymerase chain-reaction (RT-PCR), real-time PCR, enzyme-linked immunosorbent assay (ELISA). These findings demonstrated increases...
Crimes of passion, characterized as unpremeditated impulsive aggression, have garnered increasing attention in recent years. Impulsivity, a major factor crimes is also common feature various health conditions, including Borderline Personality Disorder (BPD). Childhood maltreatment considered significant precursor to BPD and closely related impulsivity. Although prior research has affirmed the relationship between impulsivity, childhood maltreatment, BPD, criminal behavior, few studies...
In the last decade, activity-dependent strategies for labelling multiple immediate early gene (IEG) ensembles in mice have generated unprecedented insight into mechanisms of memory encoding, storage, and retrieval. However, few exist brain-wide mapping ensembles, including their overlapping population, none incorporate capabilities downstream network analysis. Here, we introduce a scalable workflow to analyze traditionally coronally-sectioned datasets produced by tagging systems. Intrinsic...
In the last decade, activity-dependent strategies for labelling multiple immediate early gene (IEG) ensembles in mice have generated unprecedented insight into mechanisms of memory encoding, storage, and retrieval. However, few exist brain-wide mapping ensembles, including their overlapping population, none incorporate capabilities downstream network analysis. Here, we introduce a scalable workflow to analyze traditionally coronally-sectioned datasets produced by tagging systems. Intrinsic...
This study aims to analyze baseline profiles and longitudinal changes in Atherogenic Index of Plasma (AIP) among individuals with prediabetes identify distinct AIP trajectories assess their significance predicting diabetes onset.
Summary Background Chronic hepatitis C ( CHC ) can lead to cirrhosis and hepatocellular carcinoma HCC ). A sustained virological response SVR is associated with improved outcomes, however, its impact on different ethnic groups unknown. Aim To evaluate differences in the natural history of . Methods We conducted a cohort study 8039 consecutive adult patients seen at two medical centres California between January 1997 June 2016. Individual chart review confirmed diagnosis. Results Asian...
Abstract Mapping immediate early gene (IEG) expression across intact brains is becoming a popular approach for identifying the brain-wide activity patterns underlying behavior. Registering whole to an anatomical atlas presents technical challenge that has predominantly been tackled using automated voxel-based registration methods; however, these methods may fail when are damaged or only partially imaged, can be challenging correct, and require substantial computational power. Here we present...
Abstract In the last decade, activity-dependent strategies for labelling multiple immediate early gene (IEG) ensembles in mice have generated unprecedented insight into mechanisms of memory encoding, storage, and retrieval. However, few exist brain-wide mapping ensembles, including their overlapping population, none incorporate capabilities downstream network analysis. Here, we introduce a scalable workflow to analyze traditionally coronally-sectioned datasets produced by tagging systems....
Understanding the role of systemic inflammation in development Metabolic Syndrome (MetS) is crucial for identifying individuals at a higher risk this cluster conditions that increase heart disease, stroke, and diabetes.