A5082550710- Transplantation: Methods and Outcomes
- Pulmonary Hypertension Research and Treatments
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Vascular Anomalies and Treatments
- Congenital Heart Disease Studies
- Cancer-related gene regulation
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
- Tissue Engineering and Regenerative Medicine
- Circular RNAs in diseases
- Gout, Hyperuricemia, Uric Acid
- Virus-based gene therapy research
- Mycobacterium research and diagnosis
- Mesenchymal stem cell research
Affiliated Hospital of Guizhou Medical University
2020-2024
Zunyi Medical University
2020-2024
Guiyang Medical University
2020-2024
First People’s Hospital of Zunyi
2020
Introduction Myocardial ischemia-reperfusion injury (MIRI) is a prevalent complication in patients with myocardial infarction. The pathological mechanism of MIRI remains elusive. Ferroptosis plays critical role MIRI. This study aimed to investigate the spermidine/spermine N1-acetyltransferase 1 (Sat1) by regulation ferroptosis. Methods Rats and H9C2 cells were used perform model. extent damage associated changes evaluated. Protein expression was detected western blot. Then we observed...
Background Previous studies proved that pyrin domain-containing protein 3 (NLRP3)-induced pyroptosis plays an important role in Myocardial ischemia-reperfusion injury (MIRI). Insulin can inhibit the activation of NLRP3 inflammasome, although exact mechanism remains unclear. The aim this study was to determine whether insulin reduces NLRP3-induced by regulating pyruvate dehydrogenase E1alpha subunit (PDHA1) dephosphorylation during MIRI. Methods Rat hearts were subject 30 min global ischemia...
Abstract Vein graft failure after coronary artery bypass grafting (CABG) is primarily caused by intimal hyperplasia, which results from the phenotypic switching of venous smooth muscle cells (SMCs). This study investigates role and underlying mechanism miR-16-5p in SMCs. In rats, neointimal thickness area increased over time within 28 days CABG, as did time-dependent downregulation SMC switching. Platelet-derived growth factor-BB-induced HSVSMCs was accompanied substantially linked with...
Background Berry syndrome is a rare congenital cardiac malformation, herein we report an adult male patient who was successfully repaired by one-stage surgery. Case Description 18-year-old presenting symptoms of chest tightness and shortness for over year presented to outpatient clinic in our department have corrective procedure heart. CTA revealed Aortopulmonary Window (APW) type III, measuring 4.6 cm maximum diameter. The right pulmonary artery originated from the ascending aorta, trunk...
Immune rejection of heart transplantation has been regarded as the biggest challenge encountered by a patient suffering from end-stage disease. The human amnion-derived mesenchymal stem cells (hAD-MSCs) exhibited promising application prospects in organ transplantation. However, its persistent unsatisfactory tolerance limited widespread this technology. We aim to investigate role tumor necrosis factor-α-induced protein-8 like-2 (TIPE2)-mediated hAD-MSCs immune and molecular regulatory...
Tumor necrosis factor-α induced protein 8 like 2 (TIPE2) is one of the newly discovered negative regulators for body’s immune balance. The present study aimed to investigate effect TIPE2 gene-modified human amniotic mesenchymal stem cells (hAD-MSCs) on tolerance. In this study, over-expressed and non-transfected hAD-MSCs were severally co-cultured with injured cardiomyocytes. Cell cycle apoptosis detected by flow cytometry. viability was measured MTT, expressions immune-related factors...
Abstract Background: LncRNA ZNFX1 antisense RNA 1 (ZFAS1) is largely reported to be abnormally expressed in various human cancers and associated with unfavorable prognosis. So this study aims further investigate its clinical value multifarious cancers. Methods: Databases of PubMed, Web science, Cochrane library, Embase, Chinese National Knowledge Infrastructure Wanfang was retrieved collect eligible studies until October 22, 2020. The role ZFAS1 comprehensively assessed by STATA 12.0....