A5102027290- Immune cells in cancer
- Neonatal Respiratory Health Research
- Fatty Acid Research and Health
- Aquaculture Nutrition and Growth
- Gallbladder and Bile Duct Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Advanced Glycation End Products research
- Reproductive biology and impacts on aquatic species
- Nuclear Receptors and Signaling
- Fish Ecology and Management Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Aquaculture disease management and microbiota
- Respiratory Support and Mechanisms
- Lipid metabolism and disorders
- Bariatric Surgery and Outcomes
- Phagocytosis and Immune Regulation
- IL-33, ST2, and ILC Pathways
- Atherosclerosis and Cardiovascular Diseases
- Cholesterol and Lipid Metabolism
- Immune responses and vaccinations
Guiyang Medical University
2023-2024
Fudan University
2018-2024
China Three Gorges Corporation (China)
2024
Ningbo Medical Center Lihuili Hospital
2021-2024
Ningbo University
2021-2024
Affiliated Hospital of Guizhou Medical University
2023-2024
Wuhan Third Hospital
2022
Tongren Hospital
2022
Allergic asthma is a chronic inflammatory disease primarily mediated by Th2 immune mechanisms. Numerous studies have suggested that early life exposure to lipopolysaccharide (LPS) negatively associated with allergic asthma. One proposed mechanism invokes desensitization of lung epithelial cells LPS. We report here acyloxyacyl hydrolase (AOAH), host lipase degrades and inactivates LPS, renders mice more susceptible house dust mite (HDM)-induced Lung from Aoah-/- are refractory HDM...
Adipose tissue macrophages (ATM) are key players in the development of obesity and associated metabolic inflammation which contributes to systemic dysfunction. We here found that fibroblast activation protein α (FAP), a well-known marker cancer-associated fibroblast, is selectively expressed murine human ATM among adipose tissue-infiltrating leukocytes. Macrophage FAP deficiency protects mice against diet-induced proinflammatory macrophage infiltration obese tissues, thereby alleviating...
Although alveolar macrophages (AMs) play important roles in preventing and eliminating pulmonary infections, little is known about their regulation healthy animals. Since exposure to LPS often renders cells hyporesponsive subsequent exposures (“tolerant”), we tested the hypothesis that produced intestine reaches lungs stimulates AMs, rendering them tolerant. We found resting AMs were more likely be tolerant mice lacking acyloxyacyl hydrolase (AOAH), host lipase degrades inactivates LPS;...
The experiment was conducted to investigate the effects of feeding rates on growth performance, liver glycolysis, gluconeogenesis, glycogen synthesis, and decomposition in juvenile largemouth bronze gudgeon (
Background: N-3 long-chain polyunsaturated fatty acids (LCPUFAs) prevented non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) in studies of mouse models. We examined prospective relationships between fish oil use risk primary liver cancer the major histological subtypes, such as HCC intrahepatic cholangiocarcinoma (ICC). Methods: included 434,584 middle-aged older men women who were free at recruitment UK Biobank (2006-2010). Information on other dietary habits was...
Objectives: Macrophages play a critical role in atherosclerosis by contributing to plaque development, local inflammation, and thrombosis. Elucidation of the molecular cascades atherosclerotic macrophages is important for preventing treating atherosclerosis. This study aims deepen understanding mechanisms that regulate function aorta macrophage Methods: In current study, expression ETS variant transcription factor 6 (ETV6) mouse model. Aorta were enriched flow cytometry. ETV6 was analyzed...
Although organ hypofunction and immunosuppression are life-threatening features of severe sepsis, the hypofunctioning organs immune cells usually regain normal functionality if patients survive. Because tissue interstitial fluid can become acidic during septic response, we tested hypothesis that low extracellular pH (pHe) induce reversible metabolic functional changes in peritoneal macrophages from C57BL/6J mice. When compared with cultured at pHe, living an medium used less glucose...
Although microbe-associated molecular pattern (MAMP) molecules can promote cholesterol accumulation in macrophages, the existence of a host-derived MAMP inactivation mechanism that prevents foam cell formation has not been described. Here, we tested ability acyloxyacyl hydrolase (AOAH), host lipase inactivates gram-negative bacterial lipopolysaccharides (LPSs), to prevent mice. Following exposure small intraperitoneal dose(s) LPSs,
Oxidized phospholipids have diverse biological activities, many of which can be pathological, yet how they are inactivated in vivo is not fully understood. Here, we present evidence that a highly conserved host lipase, acyloxyacyl hydrolase (AOAH), play significant role reducing the pro-inflammatory activities two prominent products phospholipid oxidation, 1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine. AOAH removed sn-2 sn-1...
Abstract Alveolar macrophages (AMs) are sentinels in the airways, where they sense and respond to invading microbes other stimuli. Unlike locations, AMs can remain responsive Gram‐negative lipopolysaccharides (LPS) after have responded LPS vivo (they do not develop “endotoxin tolerance”), suggesting that alveolar microenvironment may influence their responses. Although epithelial cells (AECs) normally limit AMs’ innate responses, preventing inflammation induced by harmless antigens lung, how...
Women are known to be at higher risk for gallbladder disease than men, suggesting a role of female hormones in the pathogenesis disease. This study aimed assess menopausal characteristics, hormone replacement therapy (HRT) and their joint effect on long-term cholecystectomy women.
Abstract Background Obesity affects hormone metabolisms and contributes to gallstone disease more strongly in women than men. This study assessed the sex-specific associations between serum levels of sex hormone-binding globulin (SHBG) testosterone risk cholecystectomy, their mediation role obesity-cholecystectomy association. Methods Included were 176,909 men 160,147 from UK Biobank. Serum SHBG total measured by immunoassay. Incident cases cholecystectomy for identified using hospital...
Abstract Oxidized phospholipids have diverse biological activities, many of which can be pathological, yet how they are inactivated in vivo is not fully understood. Here we present evidence that a previously unsuspected host lipase, acyloxyacyl hydrolase (AOAH), play significant role reducing the pro-inflammatory activities two prominent products phospholipid oxidation, 1-palmitoyl-2-glutaryl-sn-glycero-3- phosphocholine (PGPC) and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine...