A5040831668- Neuroendocrine Tumor Research Advances
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroblastoma Research and Treatments
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Gallbladder and Bile Duct Disorders
- Peptidase Inhibition and Analysis
- Cardiomyopathy and Myosin Studies
- Metastasis and carcinoma case studies
- Pediatric Hepatobiliary Diseases and Treatments
- Viral-associated cancers and disorders
- MRI in cancer diagnosis
- Microtubule and mitosis dynamics
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Renal cell carcinoma treatment
- Wnt/β-catenin signaling in development and cancer
- Mathematical Biology Tumor Growth
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Peking Union Medical College Hospital
2011-2025
University of South China
2024
China Medical University
2024
Sichuan University
2022
First Affiliated Hospital of Harbin Medical University
2021-2022
Harbin Medical University
2021-2022
National Clinical Research
2021
European Neuroendocrine Tumor Society
2017
Lund University
2004
Arrhythmogenic cardiomyopathy (AC) shows large heterogeneity in its clinical, genetic, and pathological presentation. This study aims to provide a comprehensive atlas of end-stage AC illustrate the relationships among clinical characteristics, genotype, profiles patients with this disease.We collected 60 explanted hearts performed standard pathology examinations. The characteristics patients, their genotype cardiac magnetic resonance imaging findings were assessed along characteristics....
This study aims to investigate applicable robust biomarkers that can improve prognostic predictions for colorectal liver metastasis (CRLM) patients receiving simultaneous resection. A total of 1323 CRLM from multiple centres were included. The preoperative aspartate aminotransferase platelet ratio index (APRI) level blood obtained. Patients stratified into a high APRI group and low group, comparisons conducted by analyzing progression-free survival (PFS), overall (OS) postoperative early...
To predict the tertiary lymphoid structures (TLSs) status and recurrence-free survival (RFS) of intrahepatic cholangiocarcinoma (ICC) patients using preoperative CT radiomics.A total 116 ICC were included (training: 86; external validation: 30). The enhanced images performed for radiomics model. logistic regression analysis was applied clinical combined model based on models.A 107 features extracted, after being eliminated selected, six to establish a TLSs prediction. Arterial phase diffuse...
Neuroendocrine neoplasms (NENs) are rare tumors characterized by variable biology and delayed diagnosis. However, the nationwide epidemiology of NENs has never been reported in China. We aimed to estimate incidence survival statistics China, comparison those United States during same period.Based on data from 246 population-based cancer registries covering 272.5 million people we calculated age-specific 2017 multiplied corresponding national population The 22 were used trends 2000 through...
Colorectal neuroendocrine tumors with liver metastases (CRNELM) are associated a poorer prognosis compared to their nonmetastatic counterparts. A comprehensive understanding of the tumor microenvironment (TME) heterogeneity between primary lesions (PL) and (LM) could provide crucial insights for enhancing clinical management strategies these patients. We utilized single-cell RNA sequencing analyze fresh tissue samples from CRNELM patients, aiming elucidate variations in TME PL LM....
ABSTRACT Background Hepatocellular carcinoma (HCC) is the second leading cause of cancer‐related death in China. The rapid progress systemic therapies has led to approval many therapeutic methods that have quickly changed clinical guidelines and practices. Because high heterogeneity HCC, there are still some gaps between real‐world practice. present study surveyed experts China investigate current treatment concepts practice regarding HCC. Methods A questionnaire survey on HCC was...
Abstract Objective: This study aimed to analyze clinicopathological and prognostic features of four rare pathological subtypes primary liver malignancies make better understanding their clinical features. Methods: The data 114 patients who were diagnosed with histologically proven subtypes: clear cell carcinoma (CCC), giant (GCC), sarcomatoid (SC), combined hepatocellular-cholangiocarcinoma (CHC) between October 1998 August 2015 reviewed. Their survival compared those 908 common...
AIM:To analyze the clinicopathologic characteristics and prognostic factors of rectal neuroendocrine tumors. METHODS:The records 48 patients with tumors who were treated at Cancer Institute Hospital, Chinese Academy Medical Sciences, Beijing, from March 2004 to September 2009 retrospectively reviewed.The clinicopathological data extracted analyzed, followed-up by telephone or follow-up letter determine their survival status.Follow-up available for all patients.Uni-and multivariate Cox...
Abstract Background This study attempts to detect the expression of FoxP3, CD68, CD8α, and PD‐L1 in tumor microenvironment (TME) intrahepatic cholangiocarcinoma (ICC), analyze relationship between corresponding cells clinicopathological characteristics as well prognosis ICC. Methods RNA sequencing (RNA‐seq) provided general landscape TME A total 99 ICC patients specimens were used for multiplex immunofluorescence relapse‐free survival (RFS) was analyzed. Flow cytometry further validated...
To evaluate the efficacy and safety of lenvatinib plus programmed death-1 (PD-1) antibody as postoperative adjuvant therapy in patients with hepatocellular carcinoma (HCC) at high risks recurrence.A series 137 HCC recurrence who underwent hepatectomy our hospital between October 2019 January 2022 were retrospectively analyzed. Recurrence-free survival (RFS), overall (OS), treatment-related adverse events (TRAEs) assessed. Landmark analysis was used to compare short- long-term RFS....
Background Postoperative delirium (POD) is a common and serious complication after extensive surgery. Understanding the independent potential modifiable risk factors leading to POD in patients with head neck cancer (HNC) can provide information for future intervention trials aimed at reducing this risk. Objective To systematically analyze influencing of HNC identify high-risk individuals delirium. Methods PubMed, EMBASE, Scopus, OVID, Cochrane Library were searched publications prior June...
To predict clinical important outcomes for colorectal liver metastases (CRLM) patients receiving resection with simultaneous by integrating demographic, clinical, laboratory, and genetic data.
Abstract Background Recent studies suggest red blood cell distribution width (RDW) was a prognostic factor in various types of cancer patients, although the results are controversial. The objective this study to investigate significance RDW patients with intrahepatic cholangiocarcinoma (ICC) after radical resection. Method relationship between preoperative serum value and clinic pathological characteristics analyzed 157 ICC January 2012 June 2018 who underwent curative X-tile software used...
To investigate the predictive role of D-dimer and its combination preoperative CA19-9 for lymph node metastasis (LNM) prognosis in intrahepatic cholangiocarcinoma (ICC) patients who underwent curative-intent resection.One hundred seventy-three admitted to our hospital between April 2012 December 2018 were included. The (CPDC) was scored as 0 (decreased levels with decreased levels), 2 (elevated elevated or 1 (all other combinations). Multivariate logistic regression analysis performed...
Pancreatic neuroendocrine neoplasms (pNENs) are highly heterogeneous, and the management of pNENs patients can be intractable. To address this challenge, an expert committee was established on behalf Group Surgery, Chinese Society Medical Association, which consisted surgical oncologists, gastroenterologists, medical endocrinologists, radiologists, pathologists, nuclear medicine specialists. By reviewing important issues regarding diagnosis treatment pNENs, concluded evidence-based...
Patients with pancreatobiliary tract cancer usually have a poor clinical outcome, 5-year overall survival rate below 20%. This is mainly associated the late diagnosis. In addition, standard-of-care for patients malignant biliary stenosis involves major surgery, Whipple procedure. An accurate preoperative diagnosis, including differentiation from benign diseases, critical to avoid unnecessary treatment. Here we developed BileScreen, sensitive detection modality diagnosis of based on massively...
To investigate the predictive value of pre-operative D-dimer and gamma-glutamyltranspeptidase (GGT) for prognosis in colorectal liver metastases (CRLM) patients after hepatic resection.Two hundred ninety-two between December 2008 2016 101 at our center from January 2017 to 2018 were selected as a training set validation set, respectively. The combination GGT status (CPDG score) was scored follows: elevated levels with allocated score 2, decreased 0, all other combinations 1. In logistic...
// Rui Mao 1, * , Jian-Jun Zhao Xin-Yu Bi Ye-Fan Zhang 1 Zhi-Yu Li Jian-Guo Zhou Xiao-Long Wu Chen Xiao Hong and Jian-Qiang Cai Department of Hepatobiliary Surgery, National Cancer Center/Cancer Hospital, Chinese Academy Medical Sciences Peking Union College, Beijing, 100021, China These authors contributed equally to this work Correspondence to: Cai, email: caijianqiang@cicams.ac.cn Zhao, zhaohong@cicams.ac.cn Keywords: colorectal liver metastases, hepatectomy, early recurrence, risk...
There is little evidence regarding the optimal surgical sequence for colorectal cancer liver metastasis (CRLM) patients undergoing resection with simultaneous resection. CRLM from five centers were retrospectively evaluated. The short-term outcomes included intraoperative and postoperative outcomes. Postoperative complications measured according to Clavien–Dindo classification. Grade I II defined as minor complications. long-term progression-free survival (PFS) overall (OS). Propensity score...