A5033287955- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Neuroblastoma Research and Treatments
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Intestinal Malrotation and Obstruction Disorders
- Lipoproteins and Cardiovascular Health
- Tuberous Sclerosis Complex Research
- Diet and metabolism studies
- Colorectal Cancer Screening and Detection
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Metabolism, Diabetes, and Cancer
- Esophageal and GI Pathology
- Inflammatory Biomarkers in Disease Prognosis
- Ferroptosis and cancer prognosis
- IgG4-Related and Inflammatory Diseases
- Cancer, Hypoxia, and Metabolism
Umeå University
2020-2025
Karolinska Institutet
2015-2024
University of Colorado Anschutz Medical Campus
2020-2024
University of Colorado Denver
2020-2023
Karolinska University Hospital
2015-2023
University of Colorado Cancer Center
2023
Azienda Ospedaliera Sant'Andrea
2012-2022
Sapienza University of Rome
2013-2022
Iwate Medical University
2021
The Japanese Society of Gastroenterological Surgery
2021
Objectives Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic cysts that can progress to invasive cancer. Associations between oncogenesis and oral microbiome alterations have been reported. This study aims investigate a potential intracystic in cystic neoplasm (PCN) surgery patient cohort. Design Paired cyst fluid plasma were collected at from patients with suspected PCN (n=105). Quantitative qualitative assessment of bacterial DNA by qPCR, PacBio sequencing (n=35), interleukin...
The small intestine is one of the distant organs that become damaged during severe acute pancreatitis, due to microcirculation disturbance associated with loss fluids in "third space," hypovolemia, splanchnic vasoconstriction, and finally an ischemia-reperfusion injury. In this scenario, gut acts as starter for systemic complications, failure intestinal barrier translocation bacteria inflammatory toxic products produced wall, which can be responsible sepsis infection necrotic pancreas...
Objective: Neoadjuvant therapy (NAT) has become part of the multimodality treatment for borderline resectable pancreatic cancer (BRPC) and locally advanced (LAPC). Summary Background Data: It is currently uncertain which are preferable NAT regimens, who benefits from surgery, whether more aggressive surgical strategy motivated. Methods: A retrospective cohort analysis was performed all patients with BRPC/LAPC discussed planned at multidisciplinary conference Karolinska University Hospital...
Few studies have investigated the outcome of pancreatectomy associated with artery resection (PAR).Retrospective analysis a cohort operated borderline or locally advanced pancreatic cancer patients surgically confirmed arterial involvement. Short and long-term were analyzed compared in who underwent PAR (Group 1) palliative surgery 2).Of 73 surgical exploration intent resection, 34 (±venous resection) 39 palliation 2). 23 (67.7%) Group 1 combined artery-vein (AVR). Operation time was longer...
Objective: The purpose of this study is to determine preoperative factors that are predictive malignancy in patients undergoing pancreatic resection for intraductal papillary mucinous neoplasms (IPMN). Summary Background Data: IPMN the pancreas may be precursor lesions cancer (PC) and represent a target early diagnosis or prevention. While there has been much effort define risk malignant pathology, guidelines ever-changing controversy remains surrounding which would benefit most from...
Different inflammation-based scores such as the neutrophil/lymphocyte ratio (NLR), Odonera Prognostic Nutritional Index (PNI), Glasgow Score, platelet/lymphocyte ratio, and C-reactive protein/albumin have been found to be significantly associated with pancreatic cancer (PDAC) prognosis. However, most studies investigated patients undergoing surgery, few of them compared these scores. We aimed at evaluating association between inflammatory-based PDAC In a single center cohort study, were...
Background: Patients with chronic pancreatitis (CP) have an increased risk of developing pancreatic ductal adenocarcinoma (PDAC). We present data on PDAC in one the most extensive European single-centre cohort studies patients CP. Methods: Retrospective analysis prospectively collected CP was performed. Aetiology determined according to M-ANNHEIM classification system and only definite > 18 years at were included. The final dataset included 581 diagnosed between 2003 2018. Results: At...
// Daniele Campa 1, 2 , Manuela Pastore Manuel Gentiluomo Renata Talar-Wojnarowska 3 Juozas Kupcinskas 4 Ewa Malecka-Panas John P. Neoptolemos 5 Willem Niesen 6 Pavel Vodicka 7, 8 Gianfranco Delle Fave 9 H. Bas Bueno-de-Mesquita 10, 11, 12 Maria Gazouli 13 Paola Pacetti 14 Milena Di Leo 15 Hidemi Ito 16 Harald Klüter 17 Soucek 18, 19 Vincenzo Corbo 20 Kenji Yamao 21 Satoyo Hosono Rudolf Kaaks 22 Yogesh Vashist 23 Domenica Gioffreda 24 Oliver Strobel Yasuhiro Shimizu 25 Frederike Dijk 26...
Intraoperative pancreatoscopy is a promising procedure that might guide surgical resection for suspected main duct (MD) and mixed type (MT) intraductal papillary mucinous neoplasms (IPMNs). The aim of the present study was to assess diagnostic yield clinical impact intraoperative in patients operated on MD MT-IPMNs. This retrospective cohort study. Patients undergoing surgery or MT-IPMN underwent frozen section analysis. In all who required extended due pancreatoscopic findings, we compared...
Summary and Recommendation This statement conveys the European Society of Gastrointestinal Endoscopy (ESGE) position on use computer-aided detection (CADe) with artificial intelligence (AI) during colonoscopy for colorectal cancer (CRC) screening or surveillance. The ESGE is informed by BMJ Rapid initiative approach MAGIC Evidence Ecosystem Foundation; these include systematic reviews currently available evidence, supplemented microsimulation modeling patient values preferences, benefits...
Abstract Data on the association between aspirin and statin use Pancreatic Ductal AdenoCarcinoma (PDAC) risk are conflicting. These drugs often co-prescribed, but no studies evaluated potential combined or confounding effect of two at same time. We aimed to investigate exclusive PDAC occurrence. environmental factors, family medical history were screened in a case-control study. cases matched controls for age gender. Power calculation performed ahead. Odds ratios (OR) 95% confidence...
Zinc is a key element in numerous proteins and plays an important role essential cell functions such as defense against free radicals DNA damage repair. Chronic pancreatitis (CP) chronic inflammation with progressive fibrosis of pancreas ultimately resulting pancreatic exocrine insufficiency (PEI), which associated malnutrition. Studies analyzing zinc levels patients CP are sparse lead to conflicting results.To investigate serum various etiologies.Between October 2015 March 2018, diagnosis...
Emerging research suggests gut microbiome may play a role in pancreatic cancer initiation and progression, but cultivation of the remains challenging. This pilot study aims to investigate possibility cultivate from cystic lesions associated with invasive cancer. Intra-operatively acquired cyst fluid samples showed culture-positivity mainly intraductal papillary mucinous neoplasm (IPMN) group lesions. MALDI-TOF MS profiling analysis shows Gammaproteobacteria Bacilli dominate among individual...
Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, with a 5 year survival rate as low 9%. One factor complicating management pancreatic lack reliable tools for early diagnosis. While up to 50% adult population has been shown develop precancerous cysts, limited and insufficient approaches are currently available determine whether cyst going progress into cancer. Recently, we used metabolomics identify candidate markers disease progression in patients diagnosed...
Pancreatic neuroendocrine neoplasms (PNENs) represent 10% of all pancreatic tumors by prevalence. Their incidence has reportedly increased over recent decades in parallel with that adenocarcinoma. PNENs are relatively rare, and the few institutions have published potential risk factors, findings been heterogeneous. Our objective was to investigate association between protective factors for occurrence sporadic across a European population from several institutions. A multinational...