A5006072206- Growth Hormone and Insulin-like Growth Factors
- Pancreatic function and diabetes
- Anesthesia and Pain Management
- Pancreatitis Pathology and Treatment
- Metabolism, Diabetes, and Cancer
- Pediatric Pain Management Techniques
- Multiple Myeloma Research and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Blood groups and transfusion
- S100 Proteins and Annexins
- Traumatic Brain Injury Research
- Atrial Fibrillation Management and Outcomes
- Anesthesia and Sedative Agents
- Intestinal Malrotation and Obstruction Disorders
- Trace Elements in Health
- Traumatic Brain Injury and Neurovascular Disturbances
- Adipose Tissue and Metabolism
- Anesthesia and Neurotoxicity Research
- Platelet Disorders and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac electrophysiology and arrhythmias
- Hepatocellular Carcinoma Treatment and Prognosis
- Cytokine Signaling Pathways and Interactions
- Lipid metabolism and biosynthesis
Karolinska University Hospital
2001-2023
Karolinska Institutet
2001-2023
European Institute of Oncology
2019
Sapienza University of Rome
2019
Brain protein biomarker clearance to blood in traumatic brain injury (TBI) is not fully understood. The aim of this study was analyze the effect that a disrupted blood–brain barrier (BBB) had on clearance. Seventeen severe TBI patients admitted Karolinska University Hospital were prospectively included. Cerebrospinal fluid (CSF) and concentrations S100 calcium binding B (S100B) neuron-specific enolase (NSE) analyzed every 6–12 h for ∼1 week. Blood CSF albumin 12–24 h, BBB integrity assessed...
Zinc is a key element in numerous proteins and plays an important role essential cell functions such as defense against free radicals DNA damage repair. Chronic pancreatitis (CP) chronic inflammation with progressive fibrosis of pancreas ultimately resulting pancreatic exocrine insufficiency (PEI), which associated malnutrition. Studies analyzing zinc levels patients CP are sparse lead to conflicting results.To investigate serum various etiologies.Between October 2015 March 2018, diagnosis...
Direct oral anticoagulant (DOAC)-inhibiting factor Xa (FXa-DOAC) are being increasingly used as prophylaxis of venous thromboembolism and for prevention stroke in patients with atrial fibrillation. In contrast to vitamin K antagonists, DOACs do not require monitoring general. However, it is sometimes value the acute setting, instance when considering a reversal agent uncontrolled bleeding on DOAC.We evaluated if low-molecular weight heparin (LMWH)-calibrated anti-factor assay could be...
The regulation of the insulin-like growth factor-II gene (IGF2) is complex and involves usage four promoters resulting in different 5' untranslated regions, but with a common translated product. IGF2 product mitogenic survival factor that has been suggested to be important for normal fetal development cancer. In this paper we present evidence suggesting human regulated by GH, occurs promoter-specific way. Three lines support finding. First, vivo data from patients treated GH (one injection...
Hepatoblastoma is a poorly understood rare pediatric liver tumour. We have previously shown that the IGF-axis seriously disrupted in this tumour type. With recent discovery several other proteins also potential to bind IGFs called insulin-like growth factor binding protein related (IGFBP-rPs), we undertook an examination of such genes series hepatoblastomas with matched normal tissue. The expression profiles obtained reveal these are disturbed tumours, and may implications for our...
Abstract Background Alpha‐1‐acid glycoprotein is an acute‐phase protein with a high affinity for amide local anesthetics. Compared to adults, neonates have lower concentrations of this in plasma, and are therefore at higher risk developing anesthetic toxicity. rise adults after surgery as response stress well inflammatory conditions. Previous studies shown that alpha‐1‐acid‐glycoprotein vary postpartum, influenced by gestational age mode delivery. Aim This study aims determine the...