A5062996235- Anesthesia and Pain Management
- Cancer Treatment and Pharmacology
- Chemotherapy-induced cardiotoxicity and mitigation
- Anesthesia and Sedative Agents
- Pediatric Pain Management Techniques
- Pharmaceutical studies and practices
- Analytical Chemistry and Chromatography
- Acute Lymphoblastic Leukemia research
- Cancer Mechanisms and Therapy
- Antibiotics Pharmacokinetics and Efficacy
- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
- Nausea and vomiting management
- Respiratory Support and Mechanisms
- Chemotherapy-induced organ toxicity mitigation
- Cancer therapeutics and mechanisms
- Chronic Lymphocytic Leukemia Research
- Cardiac, Anesthesia and Surgical Outcomes
- Electron Spin Resonance Studies
- Neuroscience of respiration and sleep
- Hemodynamic Monitoring and Therapy
- Chronic Myeloid Leukemia Treatments
- Analytical Methods in Pharmaceuticals
- Chemotherapy-related skin toxicity
- Sepsis Diagnosis and Treatment
Karolinska University Hospital
2015-2025
Karolinska Institutet
2016-2025
Medical University of Vienna
2015
Svenska Örtmedicinska Institute
2010
The Ohio State University
2009
Umeå University
2008
Nobel Foundation
2008
UiT The Arctic University of Norway
2008
Uppsala University Hospital
1984-2007
Sachs' Children and Youth Hospital
2002-2006
Activation of the beta-catenin and receptor kinase pathways occurs often in medulloblastoma, most common pediatric malignant brain tumor. In this study, we show that molecular cross-talk between phosphatidylinositol 3-kinase (PI3K)/Akt signaling is crucial to sustain medulloblastoma pathophysiology. Constitutive activation phosphoinositide-dependent protein 1 (PDK1), Akt, phosphorylation [corrected] glycogen synthase 3beta (GSK-3beta) was detected by immunohistochemistry all primary...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIon pair partition chromatography of organic ammonium compoundsStaffan. Eksborg and Goran. SchillCite this: Anal. Chem. 1973, 45, 12, 2092–2100Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/ac60334a019https://doi.org/10.1021/ac60334a019research-articleACS PublicationsRequest reuse permissionsArticle Views235Altmetric-Citations119LEARN ABOUT THESE...
Background: Sodium selenite at high dose exerts antitumor effects and increases efficacy of cytostatic drugs in multiple preclinical malignancy models. We assessed the safety intravenous administered sodium cancer patients’ refractory to a phase I trial. Patients received first line chemotherapy following treatment investigate altered sensitivity these preliminary assessment any clinical benefits. Materials Methods: Thirty-four patients with different therapy resistant tumors iv daily for...
Abstract The underlying primary damage to the seminiferous epithelium caused by chemotherapeutic regimens at childhood is largely unknown. present investigation was designed identify acute cytotoxic events in testis a single dose of doxorubicin. Male rats 6, 16, and 24 days age were injected with doxorubicin (3 mg/kg, i.p.) or vehicle (saline) alone 48 hours later, germ cell types apoptotic cells examined. As indicated microscopy terminal deoxyribonucleotidyl transferase–mediated dUTP nick...
The physiological apoptosis that occurs in immature testis appears to be necessary for the maturation of this tissue. Thus, inhibition early apoptotic wave associated with first round spermatogenesis is followed by accumulation spermatogonia and infertility later life. To identify cell types undergoing rat characterize relationship between progression spermatogenesis, sequential viable segments seminiferous tubules from 8-, 18-, 26-day-old rats were examined under a phase-contrast...
Cisplatin is a cornerstone anticancer drug with pronounced ototoxicity, whereas oxaliplatin, platinum derivative different clinical profile, rarely ototoxic. This difference has not been explained. In HCT116 cells, cisplatin (20 μM)-induced apoptosis was reduced by calcium chelator from 9.9-fold induction (95% confidence interval [CI] = 8.1- to 11.7-fold), 3.1-fold CI 2.0- 4.2-fold) and superoxide scavenging 9.3-fold 8.8- 9.8-fold), 5.1-fold 4.4- 5.8-fold). A guinea pig model (n 23) used...
Tumors are considered to be possible targets of immunotherapy using stimulated and expanded autologous or allogeneic natural killer (NK) cells mismatched for MHC class I molecules inhibitory NK receptors. cell-based immunoadjuvant therapies carried out in combination with standard chemotherapeutic protocols. In the presented study, we characterized effect 28 frequently used agents on capacity kill target cells. We found that treatment drugs vinblastine, paclitaxel, docetaxel, cladribine,...
Background: Clonidine administration in the setting of paediatric anaesthesia is associated with a number desirable effects, e.g. preoperative sedation, analgesia and reduced anaesthetic requirements. The aim current study was to compare postoperative outcome variables using prospective, randomized, double‐blind design after premedication clonidine or midazolam. Methods: One hundred ASA physical status 1 patients (age 1–11 year) scheduled for adeno‐tonsillectomy were assigned receive rectal...
1. The pharmacokinetics of MTX and its 7‐hydroxy metabolite (7‐OHMTX) were investigated in nine patients with rheumatoid arthritis (RA). Each patient received 15 mg i.v., i.m. p.o. after an overnight fast a randomized cross‐over design. plasma concentrations 7‐OHMTX measured over 7 days their urinary excretion 24 h. 2. Plasma described by triexponential function i.v. administration, zero or first order absorption oral biexponential injection. all three routes administration. median terminal...
<h3>Background and Objectives</h3> To compare ropivacaine, levo-bupivacaine, racemic bupivacaine for caudal blockade in children. <h3>Methods</h3> Using a prospective observer blinded design, 60 sevoflurane anesthetized children (1 to 7 years) undergoing minor subumbilical surgery, were randomized receive block mL/kg) with either ropivacaine 0.2%, 0.25%, or levo-bupivacaine 0.25%. Postoperative analgesia (number of patients needing supplemental as defined by an objective pain score [OPS] ≥...
Aims NTBC (2‐(2‐nitro‐4‐fluoromethylbenzoyl)‐1,3‐cyclohexanedione) and mesotrione (2‐(4‐methylsulphonyl‐2‐nitrobenzoyl)‐1,3‐cyclohexanedione) are inhibitors of 4‐hydroxyphenyl pyruvate dioxygenase (HPPD). has been successfully used as a treatment for hereditary tyrosinaemia type 1 (HT‐1), while developed an herbicide. The pharmacokinetics the two compounds were investigated in healthy male volunteers following single oral administration. aim study was to assess bioequivalence different...
Prostaglandin E2 (PGE2) has been shown to play important roles in several aspects of tumor development and progression. PGE2 is synthesized from arachidonic acid by cyclooxygenases (COX) prostaglandin E synthases (PGES) mediates its biological activity through binding the four prostanoid receptors EP1 EP4. In this study, we show for first time that medulloblastoma (MB), most common malignant childhood brain tumor, expresses high levels COX-2, microsomal synthase-1, EP4 secretes PGE2. EP2...