A5101515225- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- Thermal Regulation in Medicine
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Screening and Detection
- Multiple and Secondary Primary Cancers
- Inflammatory Biomarkers in Disease Prognosis
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- RNA modifications and cancer
- COVID-19 and healthcare impacts
- Ubiquitin and proteasome pathways
- Gallbladder and Bile Duct Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Shanxi Medical University
2023
Peking Union Medical College Hospital
2008-2020
Mayo Clinic in Arizona
2020
Institute of Dermatology
2020
Fujian Medical University
2014
Fuzhou General Hospital of Nanjing Military Command
2008-2012
Background: Existing prediction models for clinically relevant postoperative pancreatic fistula after pancreatoduodenectomy lack discriminatory power or are too complex. This study aimed to develop a simple nomogram that could accurately predict pancreatoduodenectomy. Methods: A high-volume, multicenter cohort of patients who underwent from the American College Surgeons-National Surgical Quality Improvement Program database in United States during 2014-2017 was used as model training...
Abstract Structural variations (SVs) are the greatest source of in genome and can lead to oncogenesis. However, identification interpretation SVs human cancer remain technologically challenging. Here, long‐read sequencing is first employed depict signatures structural carcinogenesis pancreatic ductal epithelium. Then widespread reprogramming 3D chromatin architecture revealed by an situ Hi‐C technique. Integrative analyses indicate that distribution pattern among highly cell‐type specific...
Duodenal adenocarcinoma (DA) has a high recurrence rate, making the prediction of after surgery critically important. Our objective is to develop machine learning-based model predict postoperative DA. We conducted multicenter, retrospective cohort study in China. 1830 patients with DA who underwent radical between 2012 and 2023 were included. Wrapper methods used select optimal predictors by ten learning learners. Subsequently, these learners utilized for development. The model's performance...
Pancreatic cancer (PC), one of the most lethal malignancies, accounts for 8%–10% digestive system cancers, and incidence is increasing. Surgery, chemotherapy, radiotherapy have been main treatment methods but are not very effective. However, only 20% patients opportunity to undergo surgical operation. Approximately 30–40% present with locally advanced, unresectable pancreatic because invasion mesenteric vessels or adjacent organs. The first patient was treated Intraoperative (IORT) in 1959...
Abstract Contribution of integrin superfamily genes to treatment resistance remains uncertain. Genome patterns thirty were analyzed using bulk and single-cell RNA sequencing, mutation, copy number, methylation, clinical information, immune cell infiltration, drug sensitivity data. To select the integrins that are most strongly associated with in pancreatic cancer, a purity-independent regulation network including constructed machine learning. The exhibit extensive dysregulated expression,...
BACKGROUND Inflammation plays an important role in tumor progression, and growing evidence has confirmed that the fibrinogen-to-albumin ratio (FAR) is prognostic factor for overall survival malignant tumors. AIM To investigate significance of FAR patients undergoing radical R0 resection pancreatic ductal adenocarcinoma (PDAC). METHODS We retrospectively analyzed data 282 with PDAC who underwent at The Cancer Hospital Chinese Academy Medical Sciences from January 2010 to December 2019....
The effect of perioperative acupuncture on accelerating gastrointestinal function recovery has been reported in colorectal surgery and distal gastrectomy (Billroth-II). However, the evidence pancreatectomy other is still limited. A prospective, randomized controlled trial was conducted between May 2018 August 2019. Consecutive patients undergoing or our hospital were randomly assigned to electroacupuncture (EA) group control group. EA received transcutaneous Bai-hui (GV20), Nei-guan (PC6),...
Combination of preoperative fibrinogen and D-dimer as a prognostic indicator in pancreatic ductal adenocarcinoma patients undergoing R0 resection
Background. The necessity of preoperative biliary drainage (PBD) prior to pancreaticoduodenectomy (PD) is still controversial. However, in some settings, PBD with endoscopic retrograde cholangiopancreatography (ERCP) procedure recommended as a preferred management. Meanwhile, pancreatic duct stenting the rarely performed for selected indications, and its associated complications after PD remain quite unknown. Methods. A retrospective observational longitudinal cohort study was on patients...
Background Postoperative hospital stay after pancreaticoduodenectomy (PD) is relatively longer than other gastrointestinal operations. The aim of the current study was to investigate risk factors associated with prolonged PD. Methods Patients who had PD at Cancer Hospital Chinese Academy Medical Sciences between December 2008 and November 2012 were selected for this retrospective study. Clinical pathological data collected analyzed. primary outcome postoperative length stay. Normal discharge...
We have previously reported that hemofiltration (HF) may be an effective additional means of treating heat stroke when rapid cooling is not effective.Dogs were assigned to a (control) or + group (n = 8 each group). After induction, dogs in the HF received for 3 h. Serum concentrations interleukin (IL)-10, tumor necrosis factor (TNF)-α, IL-6, blood urea nitrogen (BUN) and creatinine measured at baseline 1, 2, h after stroke. Clearance rates solutes determined start HF.Serum all tended...
This study is aimed to investigate the association between polymorphisms in UGT2B17 and risk of developing pancreatic cancer Chinese Han population.A hospital-based case-control was conducted, 1579 healthy controls 406 patients were enrolled. Real-time PCR applied identify genetic subjects, multivariable logistic regression analysis performed susceptibility cancer.The prevalence del/del, del/ins, ins/ins cases 72.9%, 24.0%, 3.1%, respectively, 66.6%, 30.7%, 2.7%, respectively. Multivariable...
Abstract Objective: Structural variations (SVs) constitute the greatest source of genomic alterations leading to oncogenesis many cancers, including deadliest pancreatic cancer (PC). However, SVs in PC remain largely undefined due technological limitations traditional short-read sequencing. This study aims establish a comprehensive signature PC. Methods: PacBio whole genome long-read sequencing was employed investigate landscape eight tissues from four patients. A variety callers, pbsv,...
Background . The 8th American Joint Committee on Cancer (AJCC) staging system for pancreatic ductal adenocarcinoma (PDAC) outperforms its previous version in reproducibility but not survival discrimination. Tumor grade, an indicator of the aggressive biology PDAC, has been suggested as a reliable prognostic factor. This study aimed to construct novel with greater prognostication resectable PDAC by incorporating tumor grade into AJCC system. Methods A total 9966 patients from Surveillance...