A5077970092- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Colorectal and Anal Carcinomas
- RNA modifications and cancer
- Metal and Thin Film Mechanics
- Pancreatitis Pathology and Treatment
- Gastrointestinal Tumor Research and Treatment
- Computational Fluid Dynamics and Aerodynamics
- Breast Cancer Treatment Studies
- Lung Cancer Research Studies
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Electrodeposition and Electroless Coatings
- Microbial Community Ecology and Physiology
- Immune cells in cancer
- Heat shock proteins research
- Colorectal Cancer Surgical Treatments
- Rocket and propulsion systems research
- Cancer Immunotherapy and Biomarkers
- Marine and coastal ecosystems
- Galectins and Cancer Biology
- Renal cell carcinoma treatment
- Aerodynamics and Acoustics in Jet Flows
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
State Key Laboratory of Food Science and Technology
2023-2024
Jinan University
2005-2024
China Aerodynamics Research and Development Center
2015-2024
Jiangnan University
2023-2024
Taiyuan University of Technology
2022-2023
John Wiley & Sons (United States)
2023
University of Oxford
2023
John Wiley & Sons (United Kingdom)
2023
Hudson Institute
2023
Background: Gastric cancer remains the third most common cause of cancer-related death worldwide.The development novel therapeutic strategies for gastric requires a deep understanding tumor cells and microenvironment cancer.Methods: We performed single-cell RNA sequencing (scRNA-seq) on nine untreated non-metastatic patients.The transcriptomic atlas ligand-receptor-based intercellular communication networks single were characterized.Results: Here, we profiled transcriptomes 47,304 from...
Microalgae are promising feedstocks for production of renewable biofuels and value-added bioproducts. Temperature nitrogen supply important environmental nutritional factors affecting the growth metabolism microalgae, respectively. In this study, lipid accumulation filamentous microalgae Xanthonema hormidioides under different temperatures (5, 7, 10, 15, 20, 25, 27 30 °C) initial concentrations (3, 9, 18 mM) were investigated, its adaptive mechanisms tolerance to low temperature stress...
d-Allulose, a functional bulk sweetener, has recently attracted increasing attention because of its low-caloric-ness properties and diverse health effects. d-Allulose is industrially produced by the enzymatic epimerization d-fructose, which catalyzed ketose 3-epimerase (KEase). In this study, food-grade expression KEase was studied using Bacillus subtills as host. Clostridium sp. d-allulose (Clsp-DAEase) screened from nine d-allulose-producing KEases, showing better potential for in B....
Two models based on the deep learning-based convolutional neural network (CNN) and re-parameterized (RepCNN) were designed to reconstruct flame in combustor. Experiments performed a ground-pulse combustion wind tunnel at fixed inlet Mach number of 2.5 different pressures inject hydrogen obtain relevant datasets. The results showed that both could image combustor upper lower walls as well pressure which was injected. average structural similarity index between reconstructed its...
Background . The prognostic relevance of gastric tumor location has been reported and debated. Our study was conducted to examine the differences in clinicopathological features, factors, overall survival (OS) between patients with proximal cancer (PGC) distal (DGC). Patients Methods PGC or DGC were identified from China National Cancer Center Gastric Database (NCCGCDB) during 1997–2017. Survival analysis performed via Kaplan-Meier estimates Cox proportional hazards models. Results We...
Abstract Background Little is known on the tumor microenvironment (TME) response after neoadjuvant chemotherapy (NACT) in gastric cancer molecular level. Methods Here, we profiled 33,589 cell transcriptomes 14 samples from 11 patients (4 pre-treatment samples, 4 post-treatment and 3 pre-post pairs) using single-cell RNA sequencing (scRNA-seq) to generate atlas. The ligand-receptor-based intercellular communication networks of single cells were also characterized before NACT. Results Compered...
Abstract Background Pancreatic cancer is a malignancy with high mortality. Once diagnosed, effective treatment strategies are limited and the five-year survival extremely poor. Recent studies have shown that zinc finger proteins play important roles in tumorigenesis, including pancreatic cancer. However, it remains unknown on clinical significance, function underlying mechanisms of protein 488 (ZNF488) during development Methods The relevance ZNF488 stearoyl-CoA desaturase 1 (SCD1) was...
<p indent="0mm">Electrochemical (EC) technology plays an increasingly important role in energy and related fields, which presents significant challenges as well opportunities for the fundamental research of electrochemistry. Electrochemical devices such those electrolysis (<italic>e</italic>.<italic>g</italic>., hydrogen production, chlor-alkali, aluminum), fuel cells, power batteries, storage often require a high working current density (such larger than <sc>1 A cm<sup>−2</sup>)</sc> level...
Streptomycetes are well-known antibiotic producers possessing in their genomes numerous silent biosynthetic pathways that might direct the biosynthesis of novel bio-active specialized metabolites. It is thus great interest to find ways enhance expression these discover most needed antibiotics. In this study, we demonstrated over-expression acetyltransferase SCO0988 up-regulated production metabolites and accelerated sporulation weak producer, Streptomyces lividans deletion gene had opposite...
Lifestyle factors and long-term survival of gastric cancer patients: A large bidirectional cohort study from China
Abstract Background Pancreatic cancer is a malignant tumor with high mortality. Acidic nuclear phosphoprotein 32 family member E (ANP32E), specific H2A.Z chaperone, has been shown to contribute breast development. However, the significance of ANP32E in pancreatic poorly understood. This study aimed investigate role cancer. Methods The expression 179 tissues and 171 normal tissues, correlation between patients’ survival were analyzed from TCGA database. was over-expressed silenced using...
BACKGROUND Inflammation plays an important role in tumor progression, and growing evidence has confirmed that the fibrinogen-to-albumin ratio (FAR) is prognostic factor for overall survival malignant tumors. AIM To investigate significance of FAR patients undergoing radical R0 resection pancreatic ductal adenocarcinoma (PDAC). METHODS We retrospectively analyzed data 282 with PDAC who underwent at The Cancer Hospital Chinese Academy Medical Sciences from January 2010 to December 2019....
The prognostic prolongation effect of surgical resection in the management gastric neuroendocrine carcinoma (GNEC) with distant metastases was still uncertain. purpose this study to investigate association primary tumor (PTR) outcomes patients stage IV GNEC.
The effect of perioperative acupuncture on accelerating gastrointestinal function recovery has been reported in colorectal surgery and distal gastrectomy (Billroth-II). However, the evidence pancreatectomy other is still limited. A prospective, randomized controlled trial was conducted between May 2018 August 2019. Consecutive patients undergoing or our hospital were randomly assigned to electroacupuncture (EA) group control group. EA received transcutaneous Bai-hui (GV20), Nei-guan (PC6),...
Combination of preoperative fibrinogen and D-dimer as a prognostic indicator in pancreatic ductal adenocarcinoma patients undergoing R0 resection
Surface sediments were collected from three sea areas of the Qingdao coast, Yellow Sea, China, namely, inner Jiaozhou Bay, Laoshan and Amphioxus Reserve area in November to December 2017. Dinoflagellate cysts observed sediments, focusing on distribution toxic harmful species. Contents biogenic elements analyzed reveal their relationships cysts. A total 32 cyst taxa identified, including 23 autotrophic 9 heterotrophic taxa. Cyst concentrations ranged 83.3 346.5 cysts/g D Wt with an average...
Multiview learning methods often achieve improvement compared with single-view-based approaches in many applications. Due to the powerful nonlinear ability and probabilistic perspective of Gaussian process (GP), some GP-based multiview efforts were presented. However, most these make a strong assumption on kernel function (e.g., radial basis function), which limits capacity real data modeling. In order address this issue, paper, we propose novel approach by combining multikernel GP latent...