A5071178943- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Renal Transplantation Outcomes and Treatments
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Acute Kidney Injury Research
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal and related cancers
- Liver Disease and Transplantation
- Endoplasmic Reticulum Stress and Disease
- Urinary and Genital Oncology Studies
- Organ Transplantation Techniques and Outcomes
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Neurological Disorders and Treatments
- Renal cell carcinoma treatment
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Galectins and Cancer Biology
- Muscle metabolism and nutrition
- Cancer-related gene regulation
- Organ Donation and Transplantation
Guangdong Academy of Medical Sciences
2019-2024
Guangdong Provincial People's Hospital
2020-2024
Third Affiliated Hospital of Sun Yat-sen University
2014-2022
Sun Yat-sen University
2014-2022
Guangdong General Hospital
2019
Abstract Hepatocellular carcinoma (HCC) is one of the most common and lethal malignancies worldwide, epithelial–mesenchymal transition (EMT) a crucial factor affecting HCC progression metastasis. Long noncoding RNAs (lncRNAs) have been validated to act as critical regulators biological processes in various tumors. Herein, we attempted elucidate uncharacterized function mechanism lncRNA DLGAP1-AS1 regulating tumorigenesis EMT HCC. In our study, was shown be upregulated cell lines capable...
Abstract METTL3 is an RNA methyltransferase implicated in the control of cell differentiation and proliferation embryonic development cancer. The current study was aimed to explore function underlying mechanism hepatocellular carcinoma (HCC). We evaluated expression prognostic significance 100 HCC cases TCGA dataset. In cases, both protein were significantly upregulated associated with poor prognosis. Gene set enrichment analysis transcriptional profiles specimens revealed that impaired...
Mucosal apoptosis has been demonstrated to be an essential pathological feature in portal hypertensive gastropathy (PHG). p53-upregulated modulator of (PUMA) was identified as a BH3-only Bcl-2 family protein that role induced by variety stimuli, including endoplasmic reticulum (ER) stress. However, whether PUMA is involved mucosal PHG remains unclear, and induces mediating ER stress unknown. The aim the study investigate apoptotic signaling. To identify stress, gastric injury were studied...
Ischemia reperfusion injury (IRI) is a major challenge for renal transplantation. This study was performed to explore the mechanisms and potential molecular targets involved in IRI. In this study, gene datasets GSE43974 GSE126805 from Gene Expression Omnibus database, which include ischemic reperfused specimens, were analyzed determine differentially expressed genes (DEGs). ontology annotations, Kyoto Encyclopedia of Genes Genomes analysis, set enrichment analysis pathways that are...
Serine protease inhibitor Kazal type I (SPINK1) is highly expressed and promotes tumor progress in different cancers. This study aimed to evaluate SPINK1's prognostic value its role hepatocellular carcinoma (HCC) progress.We use tissue micro-arrays containing 273 paired para-tumor tissues HCC. CCK8 cell proliferation assay, wound healing assays, transwell migration invasion assays were performed explore the effect of SPINIK1 on HCC cells. The Cancer Genome Atlas (TCGA) database Gene set...
To investigate the function of discoidin domain receptor 1 (DDR1) in hepatocellular carcinoma (HCC) and to further clarify underlying mechanism.
Clear cell renal carcinoma (ccRCC) is the most common subtype of carcinoma. Redox metabolism has been recognized as hallmark cancer. But concrete role redox-related genes in patient stratification ccRCC remains unknown. Herein, we aimed to characterize molecular features based on redox gene expression profiles from The Cancer Genome Atlas. Differentially expressed (DERGs) and vital regulation were identified analyzed ccRCC. Consensus clustering was performed divide patients into three...
Renal ischemia-reperfusion injury (IRI) is an inevitable process in kidney transplantation, leading to acute injury, delayed graft function (DGF), and even loss. Ferroptosis iron-dependent regulated cell death various diseases including IRI. We aimed identify subtypes of renal IRI construct a robust DGF predictive signature based on ferroptosis-related genes (FRGs). A consensus clustering analysis was applied ferroptosis-associated 203 samples the GSE43974 dataset. The FRG-associated...
Objective. Renal ischemia–reperfusion (I/R) injury is a major cause of acute kidney (AKI) in transplanted kidneys. This study was aimed at exploring the role PLK3 (polo-like kinase 3) renal I/R injury, focusing on its relationship with oxidative stress-induced DNA damage and tubular epithelial cell (TEC) apoptosis. Methods. TRAP-seq data from development dataset GSE52004 validation GSE121191 were analyzed using GEO2R. overexpression plasmids targeted silencing siRNAs used model...
Ischemia-reperfusion injury and drug-induced nephrotoxicity are the two most common reasons for acute kidney (AKI). However, little attention has been paid to early activation of fibroblasts in progression AKI chronic disease (CKD). The present study aimed identify related genes pathways on fibroblast mouse models AKI: ischemia-reperfusion (IRI) model folic acid (FA)-induced model.The microarray expression profiles GSE62732 GSE121190 were downloaded from GEO database, differentially...
Objectives The influence of obesity on the outcomes curative liver resection for malignancies remains controversial. We aimed to compare in-hospital malignancy between obese and non-obese patients. Design This was a population-based, retrospective, observational study using data from Nationwide Inpatient Sample (NIS), largest all-payer US inpatient care database. Setting Hospitalisations adults ≥18 years old with diagnoses primary hepatobiliary or secondary malignant neoplasms in USA were...
Objectives: We aimed to analyze the effect of cold ischemia time (CIT) on post-transplant graft function through mixed-effect model analysis reduce bias caused by paired mate kidneys. Methods: reviewed all kidney transplantation records from 2015 2019 at our center. After applying exclusion criteria, 561 cases were included for analysis. All donor characteristics, preservation and matching information, recipient characteristics collected. Transplant outcomes delayed (DGF) estimated...
Abstract Background Muscular dystrophies (MD) are a group of genetically inherited disorders characterized by progressive muscle degeneration. Prior observational studies have indicated potential, yet inconclusive, links between MD and liver conditions such as non-alcoholic fatty disease (NAFLD) nonalcoholic steatohepatitis (NASH). Despite these associations, definitive causal relationship NAFLD has not been firmly established. Objective Our objective was to assess the potential...