A5103252529- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Gallbladder and Bile Duct Disorders
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- Pediatric Hepatobiliary Diseases and Treatments
- Spinal Hematomas and Complications
- Sarcoma Diagnosis and Treatment
- Biliary and Gastrointestinal Fistulas
- Spine and Intervertebral Disc Pathology
- Drug-Induced Ocular Toxicity
- Cervical and Thoracic Myelopathy
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmacological Effects of Natural Compounds
- Drug-Induced Hepatotoxicity and Protection
- RNA modifications and cancer
- Neonatal Health and Biochemistry
- Hepatitis B Virus Studies
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Viral Infections and Outbreaks Research
First Affiliated Hospital of Guangzhou Medical University
2024
The First Affiliated Hospital, Sun Yat-sen University
2006-2024
Sun Yat-sen University
2006-2024
State Key Laboratory of Respiratory Disease
2024
Guangzhou Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Peking University
2020
Guangzhou University
2006
Background Nirmatrelvir-ritonavir (Paxlovid) has received emergency use authorization from the US Food and Drug Administration owing to its effectiveness safety. However, data on safety of Paxlovid in COVID-19 patients with onset more than 5 days are lacking. Methods A real-world retrospective study was performed during outbreak involving SARS-CoV-2 BA.5.2 subvariant. Hospitalized (including mild, moderate, severe critical cases) were divided into three groups: treatment within (Group A) or...
Serine protease inhibitor Kazal type I (SPINK1) is highly expressed and promotes tumor progress in different cancers. This study aimed to evaluate SPINK1's prognostic value its role hepatocellular carcinoma (HCC) progress.We use tissue micro-arrays containing 273 paired para-tumor tissues HCC. CCK8 cell proliferation assay, wound healing assays, transwell migration invasion assays were performed explore the effect of SPINIK1 on HCC cells. The Cancer Genome Atlas (TCGA) database Gene set...
AIM:To evaluate the long-term outcome and surgical indications of hepaticojejunostomy (HJ) for treatment hepatolithiasis.METHODS: Three hundred fourteen elective cases with hepatolithiasis but without biliary stricture or cystic dilatation treated in past 10 years were reviewed retrospectively.The patients divided into HJ group T tube drainage according to procedure.Furthermore, four subgroups subdivided by hepatectomy as a balance factor, A1: hepatectomy+HJ; A2: choledochoctomy+HJ; B1: +...
Epithelial-mesenchymal transition (EMT) is critical for cancer cell metastasis. Recently, EMT was reported to be associated with the inflammatory tumour microenvironment and, therefore, might a predictive biomarker immune checkpoint blockade agents. However, underlying mechanism still unclear. Patient survival data our HCC cohort, TCGA and GEO datasets were determined by Kaplan-Meier analysis. The functional roles of ELMO1 in demonstrated series vitro vivo experiments. Gene microarray...
Since the outbreak of new coronavirus pneumonia (COVID-19) in December 2019, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), it has spread to whole country. By 12:00 am on February 28, 2020, a total 78 632 cases had been confirmed nationwide, including 2747 deaths. At present, found that people all ages are generally susceptible virus, but elderly and patients with multiple chronic diseases have highest rates illness mortality.1, According COVID-19 development treatment epidemic...
Leiomyosarcoma of the inferior vena cava (IVC) is a rare malignant tumour with poor prognosis. Surgical resection first line treatment to achieve best possible outcome. However, precise preoperative evaluation essential guide therapeutic decisions. Here, potential gadobutrol-enhanced magnetic resonance imaging (MRI) was assessed in management 42-year-old patient large IVC mass.The underwent enhanced computed tomography (CT), but relationship between left renal vein and mass dilated...
Hepatectomy is a safe and effective treatment for intrahepatic stones (IHSs). However, the resection plane right-sided distributed within 2 segments obstacle because of atrophy-hypertrophy complex formation liver difficult dissection segmental pedicle Glissonean plate by conventional approach. Thus, we devised bile duct-targeted (SBDLR) IHS, which aimed at completely diseased ducts. This study to evaluate outcomes SBDLR IHSs. From January 2009 December 2013, 107 patients with IHS treated in...
Abstract Objective Giant cervical disc herniation (GCDH) was defined as a herniated intervertebral that accounted for more than 50% of the spinal canal. The purpose this study to analyse feasibility anterior discectomy and fusion (ACDF) treatment GCDH. Methods Patient demographic imaging data, clinical results, perioperative complications were analysed retrospectively. Results A total 23 patients included in study. Spinal cord recovery pulsation observed under microscope all cases....
Supplementary Data from Multiomic Analysis Reveals Comprehensive Tumor Heterogeneity and Distinct Immune Subtypes in Multifocal Intrahepatic Cholangiocarcinoma
Supplementary Data from Multiomic Analysis Reveals Comprehensive Tumor Heterogeneity and Distinct Immune Subtypes in Multifocal Intrahepatic Cholangiocarcinoma
Supplementary Data from Multiomic Analysis Reveals Comprehensive Tumor Heterogeneity and Distinct Immune Subtypes in Multifocal Intrahepatic Cholangiocarcinoma
Supplementary Data from Multiomic Analysis Reveals Comprehensive Tumor Heterogeneity and Distinct Immune Subtypes in Multifocal Intrahepatic Cholangiocarcinoma
Supplementary Data from Multiomic Analysis Reveals Comprehensive Tumor Heterogeneity and Distinct Immune Subtypes in Multifocal Intrahepatic Cholangiocarcinoma
Objective To explore whether hepatitis B virus X protein (HBx) gene specific small interfering RNA (siRNA) enhances the effect of sorafenib promoting liver cancer cell line PLC apoptosis and possible mechanism.Methods cells were treated with HBx-siRNA or in combination sorafenib.The level HBx mRNA was assessed by using real-time quantitative polymerase chain reaction (Real-time PCR).The rate detected flow cytometry.The changes genes profiles mitogen-activated kinase (MAPK) signal pathway...
Objective To investigate the value of interventional therapy in bile duet injury （BDI） due to laparoscopic cholecystectomy （LC）. Methods Data 24 BDI patients, who received treatment after LC from June 1997 May 2007, were retrospectively analyzed. Results According Liu Yunyi criteria classification, there 5 cases type Ⅰ , 11 Ⅱ 2 Ⅲ and 6 Ⅳ. was found during patients operation switched open cholecystectomy, but duct infection experienced 10 months years operation, respectively. diagnosed...
Epithelial-mesenchymal transition (EMT) is critical for cancer cell metastasis. Recently, EMT was reported to be associated with inflammatory tumor microenvironment and therefore might a predictive biomarker immune checkpoint blockade agents. However, nderlying mechanism still unclear. Here, we report an indispensable role ELMO1 in linking mutation burden (TMB), which promising agent response. Upregulated expression poor prognosis hepatocellular carcinoma (HCC), as well increased growth,...
Background and aims: The evidence of radiofrequency ablation (RFA) following transarterial chemoembolization (TACE) combined with sorafenib for intermediate-stage recurrent hepatocellular carcinoma (RHCC) is limited. Patient responses to this treatment varied because the heterogeneous nature RHCC, making it important identify patients who are most likely benefit from combination therapy. aim study evaluate efficacy RFA TACE RHCC.Methods: A total 363 RHCC underwent (TACE-sorafenib group) or...