A5054226177- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Pediatric Hepatobiliary Diseases and Treatments
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
Sun Yat-sen University
2022-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Objective To investigate the factors influencing prognosis and survival of patients with intrahepatic cholangiocarcinoma (ICC), to construct a nomogram predict patient’s overall (OS) individually. Methods A retrospective analysis was performed in two hundred sixty-three ICC who underwent radical hepatectomy from January 2008 December 2017 First Affiliated Hospital Sun Yat-sen University. Univariate multivariate Cox proportional hazard regression methods were used screen independent OS...
Clonorchis Sinensis (C. sinensis) is a risk factor of intrahepatic cholangiocarcinoma (ICC), but the characteristics C. sinensis-related ICCs remain unclear. Here we presented an integrative analysis containing single-cell RNA-sequencing, whole exome sequencing, bulk RNA-sequencing and metabolomics in 202 ICC patients. Malignant cells were more heterogeneous fatty acid biosynthesis pathways enriched ICCs. FASN, key gene biosynthesis, was significantly up-regulated. Excretory/secretory...