A5008779235- Cancer Mechanisms and Therapy
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Phagocytosis and Immune Regulation
- FOXO transcription factor regulation
- Asymmetric Hydrogenation and Catalysis
- Organoboron and organosilicon chemistry
- Organometallic Complex Synthesis and Catalysis
- Mechanisms of cancer metastasis
- Cancer Immunotherapy and Biomarkers
- Immune responses and vaccinations
- Pancreatic and Hepatic Oncology Research
- Catalytic Cross-Coupling Reactions
- RNA modifications and cancer
- Phytochemical Studies and Bioactivities
- Radiopharmaceutical Chemistry and Applications
- Cancer-related molecular mechanisms research
- Synthetic Organic Chemistry Methods
- Luminescence and Fluorescent Materials
- Ferrocene Chemistry and Applications
- Coordination Chemistry and Organometallics
- Chemical Synthesis and Reactions
- Metal-Organic Frameworks: Synthesis and Applications
- Immune cells in cancer
- Metal complexes synthesis and properties
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Xinxiang University
2019-2022
Henan Normal University
2019-2021
Southeast University
2016
University of Massachusetts Amherst
1985
Liver metastasis is the leading cause of mortality in patients with colorectal cancer. Given significance both epithelial-mesenchymal transition (EMT) tumor cells and immune microenvironment cancer liver (CRLM), interplay between them could hold key for developing improved treatment options. We employed multiomics analysis 130 samples from 18 synchronous CRLM integrated external datasets to comprehensively evaluate interaction EMT metastasis. Single-cell RNA sequencing revealed distinct...
Abstract Bis(phosphinite) pincer platinum hydride complexes, [2,6‐(R 2 PO) C 6 H 3 ]PtH (R= t Bu, i Pr), were synthesized, characterized and applied to the hydrosilylation of aldehydes ketones. NMR study single crystal X‐ray diffraction analysis indicated that hydrides in these two complexes are comparatively less hydridic: down‐field 1 resonances (0.71 0.98 ppm) weak Pt−H interactions observed. Both found be good catalysts for ketones with phenylsilane. The corresponding alcohols isolated...
Intramolecular nucleophilic attack on the metal or phosphorus center of a POCOP pincer complex is lethal to robust backbone.
Abstract Since moisture may frequently be present in many solvents, it is important to know the reactivity of a catalyst against water for catalytic reactions. In order explore stability and understand transformation process diphosphino‐boryl‐based PBP pincer platform, [PdCl{B(NCH 2 P t Bu ) − o ‐C 6 H 4 }] ( 1 was treated with PdCl , HB(NCH PPh reacted [PdCl (cod)] (cod=cyclo‐octa‐1,5‐diene) [Pd (dba) 3 ] (dba=dibenzylideneacetone), respectively, presence water. Some novel palladium POP...
The influence of the pincer platform composition and substitution on reactivity physical properties complexes can be easily explored through different experimental techniques. However, these factors molecular structures thermodynamic stability is usually very subtle cannot always unambiguously established. To rationalize this influence, a survey crystallographic data from 130 group 10 metal supported by benzene-based PYCYP ligands, [2,6-(R2PY)2C6H3-nR'n]MX (Y = CH2, NH, O, S; M Ni, Pd, Pt; R...
Developing new approaches for efficient synthesis of diarylketones from commercially available inexpensive substrates via practical procedures is highly desirable. In this work, an effective catalytic system the was developed based on a newly synthesized Os PBP pincer complex [OsH-cis-(CO)2-mer-{κ3-P,B,P′-B(NCH2PPh2)2-o-C6H4}] (1). Complex 1 proved to be very stable against many reagents at room temperature; CS2 can only react with elevated temperatures produce...
Abstract In order to compare the structure and property of same metal center supported by different types pincer ligands, a series Ni(II) complexes, [2,6‐( i Pr 2 PNH) C 6 H 3 ]NiX (X=SH, 1 ; SPh, b SBn, c BH 4 , d ), were synthesized based on m ‐( (PNCNP) fully characterized multinuclear NMR, FTIR, X‐ray crystallography elemental analysis. The structures complexes – compared with those corresponding bis(phosphinite) (POCOP) ligand, PO) ). It was found that Ni‐C ipso Ni−S bond lengths Ni⋅⋅⋅B...
ABSTRACT A series of amphiphilic poly(N‐vinyl carbazole) (PVK) block copolymers containing tris(8‐hydroxyquinoline) aluminum (Alq 3 ) have been synthesized via reversible addition‐fragmentation chain transfer (RAFT) radical polymerization with trithiocarbonate terminated polyethylene glycol (PEG) as a RAFT agent. The chemical structures the identified by 1 H nuclear magnetic resonance and Fourier transform infrared spectrometer. analysis gel permeation chromatography indicates that...
<p>Table S1. Clinical and pathological characteristics of CRLM patients</p>
<p>Table S2. CD45+ and CD45- cell numbers of each sample from CRLM patients</p>
<p>Figure S6. Pseudotime analysis of tumor cells by Palantir and CellRank.</p>
<p>Table S1. Clinical and pathological characteristics of CRLM patients</p>
<p>Figure S8. Fn14 expression is positively correlated with the metastatic ability of colon cancer cells.</p>
<p>Figure S9. Macrophage subclusters are important in the metastasis of CRLM.</p>
<div>Abstract<p>Liver metastasis is the leading cause of mortality in patients with colorectal cancer. Given significance both epithelial–mesenchymal transition (EMT) tumor cells and immune microenvironment cancer liver (CRLM), interplay between them could hold key for developing improved treatment options. We employed multiomics analysis 130 samples from 18 synchronous CRLM integrated external datasets to comprehensively evaluate interaction EMT metastasis. Single-cell RNA...
<p>Figure S5. Dynamic change of tumor cells from primary to metastatic lesions.</p>
<p>Figure S1. Cell annotations of mCRC scRNA-seq dataset.</p>
<p>Figure S4. Extraction and validation of tumor cell analysis in mCRC cohort.</p>
<div>Abstract<p>Liver metastasis is the leading cause of mortality in patients with colorectal cancer. Given significance both epithelial–mesenchymal transition (EMT) tumor cells and immune microenvironment cancer liver (CRLM), interplay between them could hold key for developing improved treatment options. We employed multiomics analysis 130 samples from 18 synchronous CRLM integrated external datasets to comprehensively evaluate interaction EMT metastasis. Single-cell RNA...
<p>Table S3. Marker genes of subcluster for each major cell type</p>
<p>Figure S8. Fn14 expression is positively correlated with the metastatic ability of colon cancer cells.</p>