A5060662093- Cancer Mechanisms and Therapy
- Phagocytosis and Immune Regulation
- FOXO transcription factor regulation
- Cancer Immunotherapy and Biomarkers
- Mechanisms of cancer metastasis
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune responses and vaccinations
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renin-Angiotensin System Studies
- Autoimmune and Inflammatory Disorders
- Drug Transport and Resistance Mechanisms
- Biochemical and biochemical processes
- Helicobacter pylori-related gastroenterology studies
- Cancer-related gene regulation
- Pharmacological Effects and Assays
- Tumors and Oncological Cases
- Cytokine Signaling Pathways and Interactions
- Estrogen and related hormone effects
- 3D Printing in Biomedical Research
- Microscopic Colitis
- MRI in cancer diagnosis
- Cardiovascular and exercise physiology
The First Affiliated Hospital, Sun Yat-sen University
2020-2025
Sun Yat-sen University
2020-2025
Wenzhou Medical University
2010
Zhejiang Taizhou Hospital
2010
Hokkaido University
1997-1999
Liver metastasis is the leading cause of mortality in patients with colorectal cancer. Given significance both epithelial-mesenchymal transition (EMT) tumor cells and immune microenvironment cancer liver (CRLM), interplay between them could hold key for developing improved treatment options. We employed multiomics analysis 130 samples from 18 synchronous CRLM integrated external datasets to comprehensively evaluate interaction EMT metastasis. Single-cell RNA sequencing revealed distinct...
ABSTRACT Background and Aim Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer whose incidence increasing globally. However, high tumor heterogeneity of ICC restricts efficacy available systematic therapies. We aim to dissect utilizing high‐resolution single‐cell RNA sequencing identify novel therapeutic targets. Methods performed (scRNA‐seq) 26 samples from 23 patients spatial transcriptomic six sections patients. Bulk RNA‐seq data two public datasets were...
Mechanical stress can modulate the fate of cells in both physiological and extreme conditions. Recurrence tumors after thermal ablation, a radical therapy for many cancers, indicates that some tumor endure temperatures far beyond ones. This unusual heat resistance with unknown mechanisms remains key obstacle to fully realizing clinical potential ablation. By developing 3D bioprinting-based ablation system, we demonstrate hepatocellular carcinoma (HCC) this model exhibit enhanced as compared...
The effects of 10 day clenbuterol administration on cardiac and skeletal muscle capillarities were studied, particularly in terms the distribution arteriolar venular capillaries their capillary density, young (10‐week‐old) middle‐aged (37‐week‐old) male Wistar rats. Rats treated groups fed a diet containing 2 mg kg −1 hydrochloride. In both middle aged rats, treatment increased body wt weights heart hindlimb muscles. mean fibre cross‐sectional area was significantly after left ventricle,...
This study explored the diagnostic performance of visceral adiposity to predict degree intestinal inflammation and fibrosis. The patients with Crohn's disease (CD) who underwent surgical small bowel resection at First Affiliated Hospital Sun Yat-sen University (Guangzhou, China) between January 2007 December 2017 were enrolled. We evaluated imaging features computed tomography enterography (CTE), including mesenteric inflammatory fat stranding, target sign, hypervascularity, wall thickening,...
The effect of the angiotensin II type 1 receptor blockade, candesartan cilexetil (TCV116), on capillarity innermost region left ventricular subendocardium were studied in stroke-prone spontaneously hypertensive rats (SHRSP). fed for 32 days chow that contained TCV1 16, average dose being 0.96mg/kg/day. Compared with values from control SHRSP, systolic blood pressure, weight and cross-sectional area cardiomyocytes decreased. A significant increase total capillary density was coupled a...
<h3>Background</h3> Radiofrequency ablation (RFA) is a critical curative therapy for hepatocellular carcinoma (HCC). However, high recurrence rate remains major clinical challenge. Methyltransferase 5 (METTL5), an enzyme 18S m<sup>6</sup>A rRNA modification, reported to modulate stress response, however, its role in HCC after RFA unknown. Here, we explored the function and mechanism of METTL5 mediating RFA. <h3>Methods</h3> <i>In vivo</i> <i>in vitro</i> insufficient (iRFA) models were...
<p>Table S1. Clinical and pathological characteristics of CRLM patients</p>
<p>Table S2. CD45+ and CD45- cell numbers of each sample from CRLM patients</p>
<p>Figure S6. Pseudotime analysis of tumor cells by Palantir and CellRank.</p>
<p>Table S1. Clinical and pathological characteristics of CRLM patients</p>
<p>Figure S8. Fn14 expression is positively correlated with the metastatic ability of colon cancer cells.</p>
<p>Figure S9. Macrophage subclusters are important in the metastasis of CRLM.</p>
<div>Abstract<p>Liver metastasis is the leading cause of mortality in patients with colorectal cancer. Given significance both epithelial–mesenchymal transition (EMT) tumor cells and immune microenvironment cancer liver (CRLM), interplay between them could hold key for developing improved treatment options. We employed multiomics analysis 130 samples from 18 synchronous CRLM integrated external datasets to comprehensively evaluate interaction EMT metastasis. Single-cell RNA...
<p>Figure S5. Dynamic change of tumor cells from primary to metastatic lesions.</p>
<p>Figure S1. Cell annotations of mCRC scRNA-seq dataset.</p>
<p>Figure S4. Extraction and validation of tumor cell analysis in mCRC cohort.</p>
<div>Abstract<p>Liver metastasis is the leading cause of mortality in patients with colorectal cancer. Given significance both epithelial–mesenchymal transition (EMT) tumor cells and immune microenvironment cancer liver (CRLM), interplay between them could hold key for developing improved treatment options. We employed multiomics analysis 130 samples from 18 synchronous CRLM integrated external datasets to comprehensively evaluate interaction EMT metastasis. Single-cell RNA...
<p>Table S3. Marker genes of subcluster for each major cell type</p>
<p>Figure S8. Fn14 expression is positively correlated with the metastatic ability of colon cancer cells.</p>
<p>Figure S5. Dynamic change of tumor cells from primary to metastatic lesions.</p>
<p>Table S4. Significantly enriched pathways in liver metastasis</p>