A5100698628- COVID-19 Clinical Research Studies
- Cancer Treatment and Pharmacology
- Pharmaceutical Practices and Patient Outcomes
- Myasthenia Gravis and Thymoma
- Pathogenesis and Treatment of Hiccups
- COVID-19 and Mental Health
- Cancer-related molecular mechanisms research
- Drug-Induced Ocular Toxicity
- Diabetes Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Genetics, Bioinformatics, and Biomedical Research
- MRI in cancer diagnosis
- Eosinophilic Disorders and Syndromes
- Vitamin K Research Studies
- Pharmacy and Medical Practices
- Radiomics and Machine Learning in Medical Imaging
- Urticaria and Related Conditions
- Pharmaceutical studies and practices
- Medical Imaging Techniques and Applications
- Phytochemistry and Biological Activities
- Gastric Cancer Management and Outcomes
- Metabolism, Diabetes, and Cancer
- MicroRNA in disease regulation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Computational Drug Discovery Methods
Zhejiang University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
American Academy of Dermatology
2022
Beijing Hospital
2017-2018
Sir Run Run Shaw Hospital
2016
ABSTRACT 9‐Methylfascaplysin, a derivative of the marine natural product fascaplysin, has shown promising anti‐ Alzheimer's disease (AD) potential through its anti‐β‐amyloid (Aβ) neuroprotective effects. However, pharmacokinetics (PK) 9‐methylfascaplysin, crucial for preclinical evaluation, have not been thoroughly studied. In this study, we developed and validated sensitive accurate ultra‐performance liquid chromatography‐tandem mass spectrometry (UPLC‐MS/MS) method quantification...
Since the outbreak of new coronavirus pneumonia (COVID-19) in December 2019, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), it has spread to whole country. By 12:00 am on February 28, 2020, a total 78 632 cases had been confirmed nationwide, including 2747 deaths. At present, found that people all ages are generally susceptible virus, but elderly and patients with multiple chronic diseases have highest rates illness mortality.1, According COVID-19 development treatment epidemic...
Increasing evidence has shown that microRNAs are involved in apoptosis different cells. However, the role of miR-31 atherosclerosis (AS) never been elucidated. In present study, we identified impact on macrophages.The level macrophages was examined apoE-/- mice. Cell viability and were macrophage cells transfected with mimics, inhibitors or negative control. addition, NOX4 cell tested a specific siRNA targeting NADPH oxidase 4 (NOX4).An enhanced found mice, suggesting might contribute to...
ABSTRACT Sweroside, a natural secoiridoid glycoside derived from various medicinal plants, is known for its anti‐tumor, anti‐inflammatory, and hepatoprotective properties. However, pharmacological significance not fully supported by low systemic exposure. In this study, de novo strategy was proposed to investigate the metabolism of sweroside in rats, including drug administration, sample pretreatment, ultra‐high‐performance liquid chromatography/Quadrupole‐Exactive mass spectrometry data...
What is known and objective We present two cases of severe coagulation disorders induced by latamoxef, thereby revealing risk factors disorder in latamoxef-treated patients. Case summary Two very elderly patients developed haemorrhage, tests showed a longer prothrombin time (PT), activated partial thromboplastin (APTT) high international normalized ratio (INR). Latamoxef was thought to be responsible for the coagulopathy these patients, relieved after vitamin-K intake. new conclusion report...
Purpose: To compare three different pharmacokinetic models for analysis of dynamic-contrast-enhanced (DCE)-CT data with respect to acquisition times and location region interest. Methods: Eight rectal cancer patients pre-treatment DCE-CTs were included. The dynamic sequence started 4–10seconds(s) after the injection contrast agent. scan included a 110s intervals 40×1s+15×3s+4×6s. An experienced oncologist outlined tumor region. Hotspots top-5%-enhancement also identified. Pharmacokinetic was...
Objective To investigate the relationship of blood concentration tacrolimus with efficacy and safety in treatment patients myasthenia gravis. Methods The clinical data 74 gravis admitted our hospital from January 2013 to December 2015 were analyzed retrospectively. The concentrations determined by chemiluminescence microparticle immunoassay. Treatment effects evaluated relative scoring China. Results There 41 men 33 women mean age (56.7±15.8) years. According Osserman...
Pharmacogenomics is the study of impact genetic variations or genotypes individuals on their drug responses metabolism.Compared to traditional genomics research, pharmacogenomic research more closely related clinical practice.Pharmacogenomic discoveries may effectively assist clinicians and healthcare providers in determining right drugs proper doses for each patient, which can help avoid side effects adverse reactions improve effect therapy.Currently, approaches have proved be valuable when...
Objective To systematically evaluate the correlation between sodium-glucose co-tran-sporter 2 (SGLT2) inhibitors and fracture risk in type diabetes mellitus (T2DM) patients. Methods The related databases were searched. The randomized controlled trials (RCTs) which outcome index included T2DM patients treated with SGLT2 from inception to August 2017 enrolled into study. documents selected according inclusion exclusion criteria. After data extraction evaluation of methodological quality...
Objective To investigate the effect of CYP3A5 genetic polymorphism on tacrolimus concentration in myasthenia gravis patients to explore optimum doses for different genotypes. Methods The genotypes 95 treated with our hospital from January 2013 December 2015, were determined by fluorescence situ hybridization and concentrations chemiluminescence microparticle immuno assay. The differences concentrations/dosage (C/D) ratios, dosage compared among genotypes. Results There 14...
Objective To understand the patterns of outpatient prescription medications in hospital’s elderly patients. Methods Data forall prescriptionsat our hospital written for seniors (≥60 years old) between 2013 and 2014 were collected ranked based on price.The top 100 chosen analysis. Results The most expensive frequently prescribed three therapeutic groups drugs cardiovascular, endocrine & metabolic, bone joint disorders.Medication numbers prices varied among different age groups,...