A5104255011- Engineering and Information Technology
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Soil Mechanics and Vehicle Dynamics
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Viral-associated cancers and disorders
- Planetary Science and Exploration
- Geotechnical and Geomechanical Engineering
- Lung Cancer Treatments and Mutations
- Reservoir Engineering and Simulation Methods
- Long-Term Effects of COVID-19
- interferon and immune responses
- Antifungal resistance and susceptibility
- Pneumonia and Respiratory Infections
- Histiocytic Disorders and Treatments
- Infective Endocarditis Diagnosis and Management
- Modular Robots and Swarm Intelligence
- Global Cancer Incidence and Screening
- Space Exploration and Technology
- SARS-CoV-2 and COVID-19 Research
- Thermal Regulation in Medicine
- Viral Infections and Outbreaks Research
- Asthma and respiratory diseases
- Inflammatory Biomarkers in Disease Prognosis
Guangzhou Medical University
2024-2025
Second Affiliated Hospital of Guangzhou Medical University
2025
State Key Laboratory of Respiratory Disease
2024
First Affiliated Hospital of Guangzhou Medical University
2024
Background The prevalence of invasive pulmonary aspergillosis (IPA) among patients with chronic obstructive disease (COPD) is steadily increasing, leading to high mortality. Although early diagnosis can significantly reduce mortality, the efficacy current diagnostic methods limited. Consequently, there a need for novel approaches IPA detection. Methods This retrospective study involved 383 hospitalized COPD GOLD stages III and IV. group (67 patients) non-IPA (316 were identified at First...
Background Nirmatrelvir-ritonavir (Paxlovid) has received emergency use authorization from the US Food and Drug Administration owing to its effectiveness safety. However, data on safety of Paxlovid in COVID-19 patients with onset more than 5 days are lacking. Methods A real-world retrospective study was performed during outbreak involving SARS-CoV-2 BA.5.2 subvariant. Hospitalized (including mild, moderate, severe critical cases) were divided into three groups: treatment within (Group A) or...
Epstein-Barr virus (EBV), a common gamma herpesvirus, establishes life-long latent infection in the host to defend against innate immune recognition, which is closely related variety of malignant tumors, but its specific mechanism unclear. BFRF3, an EBV-encoded small capsid protein, mainly involved assembly viral structure and maintenance stability. Here, we showed that BFRF3 can inhibit TNF-α-mediated NF-кB promoter activation. Moreover, downregulates NF-кB-mediated activation transcription...
Background: Nirmatrelvir-ritonavir (Paxlovid) has received emergency use authorization from the US Food and Drug Administration (FDA) owing to its effectiveness safety. However, data on safety of Paxlovid in coronavirus disease 2019 (COVID-19) patients with onset more than five days are lacking.Methods: A real-world retrospective study was performed during outbreak involving SARS-CoV-2 BA.5.2 subvariant. Hospitalized COVID-19 (including mild, moderate, severe critical cases) were divided...
Elevated red blood cell distribution width (RDW) and decreased hematocrit (HCT) levels are associated with poor prognosis in chronic obstructive pulmonary disease (COPD) patients, but their significance intensive care unit (ICU) patients acute exacerbation of COPD (AECOPD) remains uncertain. The RDW/HCT ratio may offer a more comprehensive assessment compared to individual markers, potentially enhancing prognostic accuracy. Furthermore, the utility improving traditional ICU scoring systems...
The blood urea nitrogen/creatinine ratio (BCR) is an effective marker for disease severity stratification. Its efficacy has been demonstrated under numerous conditions. This study aims to investigate the relationship between BCR and in-hospital mortality in intensive care unit (ICU) patients with acute exacerbation of chronic obstructive pulmonary (AECOPD). Eligible ICU AECOPD from eICU database were included study. Patients divided into high-BCR low-BCR groups on basis optimal cutoff value...