A5033793564- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Respiratory viral infections research
- Infectious Diseases and Mycology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- Immunodeficiency and Autoimmune Disorders
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Gut microbiota and health
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Response and Inflammation
- Respiratory Support and Mechanisms
- Mycobacterium research and diagnosis
- Animal Disease Management and Epidemiology
- Nail Diseases and Treatments
- Advanced biosensing and bioanalysis techniques
- Neutropenia and Cancer Infections
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
First Affiliated Hospital of Guangzhou Medical University
2016-2025
Guangzhou Medical University
2016-2025
State Key Laboratory of Respiratory Disease
2016-2025
National Clinical Research
2020-2024
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2024
Shanghai International Studies University
2024
Shanghai Academy of Social Sciences
2022
Institute of Economics
2022
Health First
2020
China-Japan Friendship Hospital
2020
Abstract The outbreak of the novel coronavirus disease (COVID‐19) quickly spread all over China and to more than 20 other countries. Although virus (severe acute respiratory syndrome [SARS‐Cov‐2]) nucleic acid real‐time polymerase chain reaction (PCR) test has become standard method for diagnosis SARS‐CoV‐2 infection, these PCR kits have many limitations. In addition, high false‐negative rates were reported. There is an urgent need accurate rapid identify a large number infected patients...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for 2019 (COVID-19) pneumonia. Little known about kinetics, tissue distribution, cross-reactivity, and neutralization antibody response in patients with COVID-19. Two groups of RT-PCR-confirmed COVID-19 were enrolled this study: 12 severely ill intensive care units who needed mechanical ventilation 11 mildly isolation wards. Serial clinical samples collected laboratory detection. Results showed that most had...
Influenza remains one of the major epidemic diseases worldwide, and rapid virus replication collateral lung tissue damage caused by excessive pro-inflammatory host immune cell responses lead to high mortality rates. Thus, novel therapeutic agents that control influenza A (IAV) propagation attenuate are needed. Polysaccharide extract from Radix isatidis, a traditional Chinese herbal medicine, exerted potent anti-IAV activity against human seasonal viruses (H1N1 H3N2) avian (H6N2 H9N2) in...
Clinical value of metagenomic next-generation sequencing (mNGS) in pneumonia management is still controversial. A prospective study was conducted to evaluate the clinical impact PneumoSeq 57 immunocompetent (ICO) and 75 immunocompromised (ICH) patients. The for both etiological investigation assessed. Among 276 potential pathogens detected with our cohort, 251 (90.9%) were cross-validated. diagnoses causative obtained 97 patients, 90.7% which supported by PneumoSeq. Compared conventional...
Background The prevalence of invasive pulmonary aspergillosis (IPA) among patients with chronic obstructive disease (COPD) is steadily increasing, leading to high mortality. Although early diagnosis can significantly reduce mortality, the efficacy current diagnostic methods limited. Consequently, there a need for novel approaches IPA detection. Methods This retrospective study involved 383 hospitalized COPD GOLD stages III and IV. group (67 patients) non-IPA (316 were identified at First...
Traditional detection methods face challenges in meeting the diverse clinical needs for diagnosing both lung cancer and infections within a single test. Onco-mNGS has emerged as promising solution capable of accurately identifying infectious pathogens tumors simultaneously. However, critical evidence is still lacking regarding its diagnostic performance distinguishing between pulmonary infections, tumors, non-infectious, non-tumor conditions real settings. In this study, data were gathered...
Talaromyces marneffei is an emerging pathogen, and the number of infections in HIV-negative individuals increasing. In individuals, talaromycosis usually misdiagnosed as another disease, especially tuberculosis (TB). We retrospectively extracted clinical data patients with infection from 2018 to 2023, analyzed differences between TB attempted establish differential diagnosis models utilizing prediction for these two diseases. Overall, 718 patients, including 137 581 pulmonary (PTB), were...
Abstract Background High-titer anti-interferon (IFN)-γ autoantibodies are strongly associated with intracellular pathogens such as nontuberculous mycobacteria and Talaromyces marneffei , but they not commonly co-infected Mycobacterium tuberculosis . Case presentation Herein, we report a case of an HIV-negative Chinese man severe, disseminated co-infection who had high-titer anti IFN-γ CFI heterozygous nonsense gene mutation. The patient rapidly developed sepsis died. Through by flow...
Considering the role of bacteria in onset acute exacerbation COPD (AECOPD), we hypothesized that use influenza-Streptococcus pneumoniae vaccination, oral probiotics or inhaled amikacin could prevent AECOPD. In this pilot prospective, muti-central, randomized trial, moderate-to-very severe subjects with a history moderate-to-severe exacerbations previous year were enrolled and assigned ratio 1:1:1:1 into 4 groups. All participants managed based on conventional treatment recommended by GOLD...
ABSTRACT Anti-interferon-γ autoantibody (AIGA) syndrome may be the basis of disseminated Talaromyces marneffei infection in human immunodeficiency virus (HIV)-negative adults. However, pathogenesis Th1 cell immunity T. with AIGA is unknown. A multicenter study HIV-negative individuals was conducted between September 2018 and 2020 Guangdong Guangxi, China. Patients were divided into AIGA-positive (AP) AIGA-negative (AN) groups according to titer neutralizing activity. The relationship immune...
Background Nirmatrelvir-ritonavir (Paxlovid) has received emergency use authorization from the US Food and Drug Administration owing to its effectiveness safety. However, data on safety of Paxlovid in COVID-19 patients with onset more than 5 days are lacking. Methods A real-world retrospective study was performed during outbreak involving SARS-CoV-2 BA.5.2 subvariant. Hospitalized (including mild, moderate, severe critical cases) were divided into three groups: treatment within (Group A) or...
Bone morphogenetic protein 4 (BMP4) is a multifunctional growth factor that belongs to the TGF‐β superfamily. The role of BMP4 in lung diseases not fully understood. Here, we demonstrate was upregulated lungs undergoing lipopolysaccharide (LPS)‐induced inflammation, and airway epithelial cells treated with LPS or TNF‐α. mutant ( +/− ) mice presented more severe inflammation response Pseudomonas aeruginosa , lower bacterial load compared +/+ mice. Knockdown by siRNA increased TNF‐α‐induced...