A5008289605- Advanced biosensing and bioanalysis techniques
- COVID-19 Clinical Research Studies
- Extracellular vesicles in disease
- SARS-CoV-2 and COVID-19 Research
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Protease and Inhibitor Mechanisms
- Chromatin Remodeling and Cancer
- MicroRNA in disease regulation
- SARS-CoV-2 detection and testing
- HIV Research and Treatment
- Inflammatory mediators and NSAID effects
- Cancer-related Molecular Pathways
- Renal and related cancers
- Immune cells in cancer
- Microtubule and mitosis dynamics
- Estrogen and related hormone effects
- Peroxisome Proliferator-Activated Receptors
- Polyamine Metabolism and Applications
- Olfactory and Sensory Function Studies
- Photochromic and Fluorescence Chemistry
- Hedgehog Signaling Pathway Studies
- RNA Interference and Gene Delivery
- Histone Deacetylase Inhibitors Research
- Nanocluster Synthesis and Applications
Harbin Medical University
2025
Fourth Affiliated Hospital of Harbin Medical University
2025
Nanjing Sport Institute
2024
Nanjing University of Chinese Medicine
2018-2023
Weatherford College
2023
Nanjing Second Hospital
2009-2021
Acupuncture And Massage College
2020
Southeast University
2009-2019
Jinggangshan University
2014
Nanjing Medical University
2006
Abstract The outbreak of the novel coronavirus disease (COVID‐19) quickly spread all over China and to more than 20 other countries. Although virus (severe acute respiratory syndrome [SARS‐Cov‐2]) nucleic acid real‐time polymerase chain reaction (PCR) test has become standard method for diagnosis SARS‐CoV‐2 infection, these PCR kits have many limitations. In addition, high false‐negative rates were reported. There is an urgent need accurate rapid identify a large number infected patients...
Effective strategy to mitigate the ongoing pandemic of 2019 novel coronavirus (COVID-19) require a comprehensive understanding humoral responses against severe acute respiratory syndrome 2 (SARS-CoV-2), emerging virus causing COVID-19. The dynamic profile viral replication and shedding along with antigen specific antibody among COVID-19 patients started be reported but there is no consensus on their patterns. Here, we conducted serial investigation 21 individuals infected SARS-CoV-2 in two...
Abstract Background Assessment of immune function is key importance in recognition disease or healthy status, which still faces challenge clinical practice. We conducted a 10-center study to investigate lymphocyte parameters including the number, phenotype and IFN-γ-producing ability, routine laboratory indicators by using standard method. Results Although heterogeneity was widely found, we have established normal ranges these pooled data showed no significant difference among centers....
Abstract Patients with non‐small‐cell lung cancer (NSCLC) are routinely treated the platinum‐based chemotherapeutics such as cisplatin. The drug exerts anticancer effects via multiple mechanisms, including DNA double‐strand breaks (DSBs). Enhanced DSB repair capacity would be associated innate or acquired resistance. However, despite strong evidence for role of chromokinesin kinesin family member 4A (KIF4A) in repair, relationship between and cisplatin sensitivity human NSCLC cells remains...
Colorectal cancer (CRC) is one of the major causes cancer-associated mortality worldwide. Wnt family member 10A (Wnt10a) an oncogene associated with carcinogenesis and progression renal cell carcinoma, strongly expressed in CRC line SW480. However, role Wnt10a has been rarely reported. In present study, expression levels were higher 40 tumor tissues compared paired control tissues, as determined by RT-qPCR method. addition, clinic opathological association analysis indicated that was stage...
Nonalcoholic fatty liver disease (NAFLD) is considered a risk factor for severe COVID-19, but the mechanism remains unknown. This study used bioinformatics to help define relationship between these diseases. The GSE147507 (COVID-19), GSE126848 (NAFLD), and GSE63067 (NAFLD-2) datasets were screened using Gene Expression Omnibus. Common differentially expressed genes then identified Venn diagram. ontology analysis KEGG pathway enrichment performed on genes. A protein-protein interaction...
The hominoid oncogene TBC1D3 enhances epidermal growth factor receptor (EGFR) signaling and induces cell transformation. However, little is known regarding its spatio-temporal regulation mechanism of tumorigenesis. In the current study, we identified microtubule subunit β-tubulin as a potential interaction partner for using affinity purification combined with mass spectrometry analysis. between was confirmed by co-immunoprecipitation. Using same method, also revealed that co-precipitated...
CD4+CD25+ T cells play a major role in modulating immune response, but few reports have been published about schistosomiasis. Here, we investigated the changes cell populations spleens and mesenteric lymph nodes of mice infected with Schistosoma japonicum. The proportions total CD4+ were analyzed by flow cytometry. CD25 Foxp3 expression was measured real-time quantitative polymerase chain reaction. suppressive activities detected vitro proliferation splenocytes. Evidence showed that...
The hominoid oncoprotein TBC1D3 enhances growth factor (GF) signaling and GF signaling, conversely, induces the ubiquitination subsequent degradation of TBC1D3. However, little is known regarding regulation this degradation, role in progression tumors has also not been defined. In present study, we demonstrated that calmodulin (CaM), a ubiquitous cellular calcium sensor, specifically interacted with Ca2+-dependent manner inhibited signaling-induced both cytoplasm nucleus human breast cancer...
Herein, an electrochemical method to detect histone acetyltransferases activity (HAT) has been developed based on the reduction of G-Quadruplex-Cu(ii) metalloenzyme activity. A G-quadruplex-Cu(ii) excellent peroxidase property, generating strong signal. In presence HAT, it can catalyze substrate peptide acetylation and produce large amounts Coenzyme (CoA). The signal is weak due competitive combination between G-Quadruplex CoA with Cu(ii), resulting in direct quantitative detection HAT....
As a common ophthalmic disease, dry eye (DE) may bring several adverse effects on the quality of life for patients. In recent years, Acupuncture (AC) is becoming increasingly popular treating DE. Thus, we conceived this systematic review aims to evaluate effectiveness and safety AC DE objectively.The search results are restricted randomized controlled trials human studies. We will establish inclusion criteria through discussion design detailed literature strategy each database. Articles...
Sepsis is the most common cause of acute kidney injury (AKI). Based on microarray-based clustering analysis miRNAs altered in kidneys LPS-AKI mice, miR-20a-3p was upregulated tissues lipopolysaccharide (LPS)-treated mice. We aimed to reveal functions septic AKI by establishing LPS-stimulated mouse model and constructing HK-2 cells. Reverse transcription-quantitative PCR used quantify expression inflammation-associated factors including MCP-1, TNF-α, IL-6. Silencing reduced inflammation...