A5006354171- HIV/AIDS drug development and treatment
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- HIV Research and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Spinal Fractures and Fixation Techniques
- Intensive Care Unit Cognitive Disorders
- MicroRNA in disease regulation
- Thermal Regulation in Medicine
- Spine and Intervertebral Disc Pathology
- Phenothiazines and Benzothiazines Synthesis and Activities
- Hip and Femur Fractures
- Pelvic and Acetabular Injuries
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Biochemical and Molecular Research
- Synthesis and biological activity
- Pneumocystis jirovecii pneumonia detection and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Click Chemistry and Applications
- advanced mathematical theories
- Thyroid and Parathyroid Surgery
- Advanced Numerical Analysis Techniques
- Inflammation biomarkers and pathways
- Enzyme function and inhibition
First Affiliated Hospital of Guangzhou Medical University
2024
State Key Laboratory of Respiratory Disease
2024
Guangzhou Medical University
2024
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2024
Shandong University
2010-2023
Ningbo University
2020-2023
Wuhan University
2023
Taishan University
2023
First Affiliated Hospital of Chengdu Medical College
2018-2021
People's Hospital of Yangzhong
2020
White matter injury (WMI) is an important pathological process after traumatic brain (TBI). The correlation between white functions and the myeloid cells expressing triggering receptor-2 (TREM2) has been convincingly demonstrated. Moreover, a recent study revealed that microglial sterol metabolism crucial for early remyelination demyelinating diseases. However, potential roles of TREM2 expression in WMI TBI have not yet explored.
Purpose To depict the long-term outcome of patients with myasthenia gravis after thymectomy in combination immunotherapy, and factors that may potentially affect outcome. Methods The 306 who underwent extended from January 1984 to December 2011 at Tongji Hospital were retrospectively evaluated. Results consisted 174 cases thymoma 132 without thymoma. Pharmaceutical treatment was tailored for each case during follow-up. Nine thymomatous died perioperative period, 297 followed 8.6 years. By...
Abstract A convenient method to evaluate bone cement distribution following vertebral augmentation is lacking, and therefore so our understanding of the optimal distribution. To address these questions, we conducted a retrospective study using data from patients with single-segment fracture who were treated at two hospitals. Five evaluation methods based on X-ray film compared determine best Of 263 included, 49 (18.63%) experienced re-collapse vertebrae 119 (45.25%) new fractures during...
Abstract Previous studies failed to elucidate the detailed mechanisms of anesthetic preconditioning as a protective approach against ischemic/reperfusion (I/R) injury in cells. The present study mainly centered on discovering Sevoflurane (Sev) preventing cardiomyocytes I/R injury. Human cardiomyocyte AC16 cell line was used simulate based hypoxia/reperfusion (H/R) model. After Sev treatment, viability and apoptosis were detected by MTT assay flow cytometry, respectively. Lactate...
Myocardial ischemia/reperfusion (MI/RI) syndrome is one of the leading causes mortality and disability. Propofol postconditioning known to improve myocardial injury (MI/RI). The present study aimed explore mechanism propofol in diabetic MI/RI. Diabetic MI/RI rat models were established rats treated via postconditioning. Staining with 2,3,5‑triphenyl‑2H‑tetrazolium chloride, H&E staining, TUNEL staining ELISA applied detect infarct size, pathological changes, apoptosis oxidative...
(‑)Epigallocatechin‑3‑gallate (EGCG) is a type of polyphenol monomer and the predominant component catechin compounds extractable from green tea. Previous studies have demonstrated that EGCG exhibits numerous bioactivities both in vitro vivo, including antitumor, antioxidant anti‑inflammatory activities, as well lowering blood lipid levels protecting against radiation. The present study aimed to investigate whether administration may attenuate anesthesia‑induced memory deficit young mice...
Three-dimensional quantitative structure-activity relationship (3D-QSAR) studies were performed based on a series of azaindole carboxylic acid derivatives that had previously been reported as promising HIV-1 integrase inhibitors. Docking to explore the binding mode highly active molecule 36. The best docked conformation 36 was used template for alignment. comparative molecular field analysis (CoMFA) model (including steric and electrostatic fields) yielded cross validation q (2) = 0.655,...
It is unclear whether the sandwich vertebra, at higher risk of new symptomatic fractures (NSFs), and prophylactic augmentation might benefit patients with vertebrae.To compare fracture-free probabilities sandwich, ordinary-adjacent, non-adjacent vertebrae, identify predictors NSFs.Data were retrospectively analyzed for who had undergone vertebral resulting in vertebrae. NSF rates determined identified using Cox proportional hazard models.The analysis included 1408 untreated vertebrae (147...
Neuroinflammation plays a dominant role in the progression of postoperative cognitive dysfunction (POCD). Vitamin D has been known to have important regulatory functions inflammation and immune response. The NOD-like receptor protein 3 (NLRP3) is an essential inflammasome inflammatory response could be activated by anesthesia surgery. In this study, male C57BL/6 mice aged 14-16 months were given VD3 for 14 days straight before having open tibial fracture animals either sacrificed obtain...
Four series of forty-five nitrogen-containing polyhydroxylated aromatics based on caffeic acid phenethyl ester were designed and synthesized as HIV-1 integrase (IN) inhibitors. Most these compounds inhibited IN catalytic activities in low micromolar range. Among new analogues, 9e 9f the most potent inhibitors with IC50 value 0.7 μM against strand transfer reaction. Their key structure-activity relationships also discussed.
Anesthetics exposure induces neurocognitive deficits during brain development and impairs self-renewal differentiation of neural stem cells (NSCs). Tripartite motif 72 (TRIM72, also known as mitsugumin 53, MG53) is involved in tissue repair plasma membrane damage repair. The neuroprotective effect TRIM72 against sevoflurane-induced neurotoxicity NSCs was investigated this study. First, human were exposed to different concentrations sevoflurane. Results showed that downregulated...
Endothelial dysfunction caused by high glucose is recognized as an important event in the pathogenesis of diabetes-related vascular complications. Ropivacaine considered to have best safety profile among commonly used amide local anesthetics, but extent its actions remains incompletely understood. Here, we human umbilical vein endothelial cells exposed explore effects ropivacaine on oxidative stress and markers inflammation. treatment exerted significant beneficial rescuing downregulating...
Our study aimed to investigate the effects of propofol medium and long chain lipid emulsion on cognitive function patients with hepatic encephalopathy undergoing hemofiltration treatment.A total 87 diagnosed from January 2014 2016 were continuously selected, randomly (using random number method) divided into an observation group (45 cases) a control (42 cases). All treated persistent hemofiltration; in not given any sedative measures, while medium-long injection dose determined by each...