A5085157310- Myasthenia Gravis and Thymoma
- Hearing Loss and Rehabilitation
- Peripheral Neuropathies and Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Inflammatory Myopathies and Dermatomyositis
- Muscle Physiology and Disorders
- Multiple Sclerosis Research Studies
- Parkinson's Disease and Spinal Disorders
- T-cell and B-cell Immunology
- Pituitary Gland Disorders and Treatments
- Speech and Audio Processing
- Genetic Neurodegenerative Diseases
- Thyroid and Parathyroid Surgery
- Ear Surgery and Otitis Media
- Psoriasis: Treatment and Pathogenesis
- Hereditary Neurological Disorders
- Autoimmune and Inflammatory Disorders Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Thyroid Cancer Diagnosis and Treatment
- Autoimmune Neurological Disorders and Treatments
- Neurogenetic and Muscular Disorders Research
- FOXO transcription factor regulation
- Immune Cell Function and Interaction
- Neurological and metabolic disorders
- Diet, Metabolism, and Disease
Tongji Hospital
2014-2025
Huazhong University of Science and Technology
2014-2025
Beijing Chao-Yang Hospital
2024-2025
Capital Medical University
2021-2025
Beijing Tongren Hospital
2021-2022
Ministry of Education of the People's Republic of China
2021-2022
Henan University of Science and Technology
2022
First Hospital of Jilin University
2017-2020
Jilin University
2017-2020
The University of Texas MD Anderson Cancer Center
2014
Tofacitinib, a first-generation Janus kinase (JAK) 1/3 inhibitor, is commonly used for treating ulcerative colitis and rheumatoid arthritis. However, its role in myasthenia gravis (MG) remains unclear. This study aimed to evaluate the immunomodulatory effects of tofacitinib on experimental autoimmune (EAMG) peripheral blood mononuclear cells (PBMCs) from patients with MG. Flow cytometry, enzyme-linked immunosorbent assay (ELISA), quantitative reverse transcription polymerase chain reaction...
Our previous studies have investigated the role of hepatic insulin resistance (hepatic IR) and islet β-cell function in pathogenesis diabetes. This study aimed to explore contributions IR dysfunction blood glucose spectrum patients with newly diagnosed type 2 diabetes mellitus. Hepatic was assessed by index (HIRI). Islet secretion- sensitivity index-2 (ISSI2). The associations between ISSI2 were analyzed. A total 707 new-onset included. fasting (FBG) 30 minutes postload elevated rising HIRI...
Natural killer (NK) cells, a major component of the innate immune system, have prominent immunoregulatory, antitumor proliferation, and antiviral activities. NK cells act as double-edged sword with therapeutic potential in neurological autoimmunity. Emerging evidence has identified are involved development progression neuroimmunological diseases such multiple sclerosis, neuromyelitis optica spectrum disorders, autoimmune encephalitis, Guillain-Barré Syndrome, chronic inflammatory...
Objectives: Endoplasmic reticulum (ER) stress plays pivotal roles in the regulation of skeletal muscle damage and dysfunction multiple disease conditions. We postulate activation ER idiopathic inflammatory myopathies (IIM). Methods: Thirty-seven patients with immune-mediated necrotizing myopathy (IMNM), 21 dermatomyositis (DM), 6 anti-synthetase syndrome (ASS), 10 controls were enrolled. The expression stress-induced autophagy pathway was detected using histological sections, Western blot,...
Purpose To depict the long-term outcome of patients with myasthenia gravis after thymectomy in combination immunotherapy, and factors that may potentially affect outcome. Methods The 306 who underwent extended from January 1984 to December 2011 at Tongji Hospital were retrospectively evaluated. Results consisted 174 cases thymoma 132 without thymoma. Pharmaceutical treatment was tailored for each case during follow-up. Nine thymomatous died perioperative period, 297 followed 8.6 years. By...
Abstract Objectives The study aimed to explore the association between thyroid hormone (TH) sensitivity and obesity assessed by body mass index (BMI) visceral adiposity (VAI) in euthyroid adults. Methods This cross-sectional used Thyroid Feedback Quantile-based Index (TFQI), TSH (TSHI), thyrotrophic T4 resistance (TT4RI) indicate central TH sensitivity, VAI assess obesity. Participants were categorized according tertiles. We logistic linear regressions associations stratified sex. Results...
Objectives To describe the clinical predictors and immune-related factors for exacerbation in adults with well-controlled generalized myasthenia gravis (GMG). Methods We conducted a retrospective analysis of 585 GMG from our institution to explore risk exacerbation. Furthermore, propensity score matching (PSM) was used compare proportions lymphocyte subsets, levels immunoglobulin, complement, anti-acetylcholine receptor antibody (AChR-ab) peripheral blood 111 patients exacerbations 72...
Cochlear nerve deficiency (CND) is often associated with variable outcomes of cochlear implantation (CI). We assessed previous investigations aiming to identify the main factors that determine CI outcomes, which would enable us develop predictive models. Seventy patients CND and normal cochlea who underwent surgery were retrospectively examined. First, using a data-driven approach, we collected demographic information, radiographic measurements, audiological findings, audition speech...
Diabetic striatopathy (DS) is a rare complication secondary to hyperglycemia, featured by the choreiform movements and reversible striatal abnormalities on neuroimaging. Several studies have described clinical characteristics of DS, however, simultaneous occurrence DS acute ischemic stroke (AIS) in striatum has not been reported. Herein, we report 68-year-old man with uncontrolled type 2 diabetes who experienced progressive involuntary movement right upper lower limbs for 10 days. We...
Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are common demyelinating disorders of the central nervous system. The etiology pathogenesis MS NMOSD remain unclear. these two diseases involves a genetic predisposition as well environmental factors. sometimes co-exists with Sjögren's syndrome, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), frequently associated system involvement, manifest in MS- NMOSD-like clinical features. Genetic variant...
NK cells are dysfunctional in myasthenia gravis (MG), but the mechanism is unclear. This study aims to measure associations and underlying mechanisms between development of MG.
Abstract Objectives This study aimed to evaluate the therapeutic efficacy of telitacicept based on conventional treatment in adults with idiopathic inflammatory myopathy (IIM), focusing its impact clinical manifestations. Methods IIM patients who had been treated for at least 3 months from January 2023 2024 were included this study. The response was determined ACR/EULAR criteria minimal, moderate and major improvement Total Improvement Score. Disease activity monitored using core set...
The aim of this study was to elucidate the clinical and myopathological characteristics patients with anti-signal recognition particle (SRP) positive immune-mediated necrotizing myopathy (IMNM) overlap Sjogren's syndrome (SS).We retrospectively analyzed data anti-SRP IMNM admitted in Neurology Department Tongji Hospital between January 2011 December 2020. Patients were divided into two groups: SS group control group. features, laboratory results, histological treatment, prognosis compared...
Purpose: Owing to the characteristic anatomy, cochlear implantation (CI) for common cavity deformity (CCD) has resulted in varied outcomes and frequent facial vestibular nerve stimulation. The current study analyzed correlation among distance between each electrode wall (abbreviation, D), programming parameters, performances outcomes. Materials Methods: current, retrospective included 25 patients (27 ears) with CCD underwent CI. multiplanar volume reconstruction (MPVR) techniques were...
Immunophenotypes are related to the therapeutic efficacy of specific immunomodulating agents in patients with myasthenia gravis (MG), but relationship immunophenotype presence or absence thyroid antibodies is unknown. This study aims evaluate differences immunophenotypes between MG and without antibody (TAb) positivity provide insight for future targeted immunotherapies.This retrospective observational included 48 acetylcholine receptor (AchR-Ab), which 15 (31.25%) were TAb positive. Ocular...
Nearly 10% to 20% of myasthenia gravis (MG) patients are refractory conventional treatment for unclear reasons. The study aimed explore the relationship between drug metabolism gene polymorphisms and MG.One hundred thirty-one MG (33 in group; 98 non-refractory group) admitted Tongji Hospital were included this retrospective study. Improved multiplex ligation detection reaction (iMLDR) was used genotype 13 (NR3C1 rs17209237, rs9324921; FKBP5 rs1360780, rs4713904, rs9296158; HSP90AA1...
TNF-like weak inducer of apoptosis (TWEAK) and its sole receptor fibroblast growth factor-inducible 14 (Fn14) are involved in various inflammatory conditions. This study was performed to investigate the potential role TWEAK/Fn14 immune-mediated necrotizing myopathy (IMNM).Muscle biopsies from patients with IMNM (n = 37) controls 11) were collected. Human muscle cells treated TWEAK vitro. Muscle cultured analysed by immunostaining quantitative PCR. Serum levels Fn14 detected ELISA.TWEAK...
Abstract Objective This study aimed to assess the correlation between residual hearing and audiologic outcomes after cochlear implant (CI) surgery in patients with nerve deficiency (CND). Methods retrospective included 57 CND who underwent CI surgery. Patients were divided into four groups according level (80–95, 95–110, 110–120, >120 dB) three (entire spectrum hearing, partial no hearing) based on measured response at each frequency. Auditory performance (categorical auditory [CAP],...
Background: Limb−girdle muscular dystrophy R2 (LGMD R2) is most frequently misdiagnosed as immune-mediated necrotizing myopathy (IMNM). This study aimed to compare the clinicopathological data of IMNM and LGMD find distinguishing features. Methods: We retrospectively reassessed medical patients with (n = 41) 8) treated at Tongji Hospital from January 2017 December 2021. Results: In our cohort, had a longer interval onset first visit, mild muscle weakness late upper limb involvement, less...
Object To investigate the long-term development of auditory and speech in patients with common cavity deformity (CCD) after cochlear implantation (CI) its relationship to imaging characteristics. Methods Twenty-three CCD 59 age- sex-matched CI children normal inner ear structure were recruited. The these two groups evaluated at 0, 1, 3, 6, 12, 18 months activation using four parent reports questionnaires [Categories Auditory Performance (CAP), Speech Intelligibility Rating (SIR), Meaningful...