A5100458391- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Speech and Audio Processing
- Vestibular and auditory disorders
- Ear Surgery and Otitis Media
- Noise Effects and Management
- Knee injuries and reconstruction techniques
- Musculoskeletal synovial abnormalities and treatments
- Spinal Fractures and Fixation Techniques
- Shoulder Injury and Treatment
- Spine and Intervertebral Disc Pathology
- Tendon Structure and Treatment
- Immune Response and Inflammation
- Neurogenesis and neuroplasticity mechanisms
- Neurological disorders and treatments
- interferon and immune responses
- Sports injuries and prevention
- Cytokine Signaling Pathways and Interactions
- Venous Thromboembolism Diagnosis and Management
- Neuroendocrine regulation and behavior
- Congenital Ear and Nasal Anomalies
- Ocular Surface and Contact Lens
- Neural dynamics and brain function
- Vascular Malformations and Hemangiomas
- Nuclear Receptors and Signaling
Second Hospital of Anhui Medical University
2024-2025
Anhui Medical University
2020-2025
Beijing Tongren Hospital
2017-2024
Capital Medical University
2009-2024
Guizhou University
2020-2024
Zhongnan Hospital of Wuhan University
2013-2023
Wuhan University
2013-2023
Tongren Hospital
2023
Urumqi 4th People's Hospital
2023
Zhejiang Hospital
2022-2023
Chronic restraint stress, psychosocial as well systemic or oral administration of the stress-hormone corticosterone induces a morphological reorganization in rat hippocampus, which adrenal steroids and excitatory amino acids mediate reversible remodeling apical dendrites on CA3 pyramidal cell neurons hippocampus. This stress-induced neuronal is accompanied also by behavioral changes, some can be prevented with selective antidepressant anticonvulsive drug treatments. Lithium an effective...
The JAK/STAT1 pathway is generally activated by cytokines, providing essential antiviral defense. Here, we identify that STAT1 activation independent of cytokines and JAKs at the early infection stage some viruses, including influenza A virus (IAV). Instead, mainly through spleen tyrosine kinase (Syk) downstream retinoic acid-inducible gene-I/mitochondrial antiviral-signaling protein (RIG-I/MAVS) signaling. Syk deletion profoundly impairs immediate innate immunity, as evidenced finding...
Influenza A virus (IAV) remains a major public health threat in the world, as indicated by severe pneumonia caused its infection annually. Interleukin-6 (IL-6) involved excessive inflammatory response to IAV profoundly contributes pathogenesis. However, precise mechanisms underlying such are poorly understood. Here we found from both vivo and vitro studies that not only induced surge of IL-6 release, but also greatly upregulated expression suppressor cytokine signaling-3 (SOCS3), potent...
The looming antibiotic-resistance problem has imposed an enormous crisis on global public health and agricultural development. Even worse, the evolution widespread distribution of elements in bacterial pathogens have made resurgence diseases that were once easily treatable deadly again. development antibiotics with novel mechanisms action is urgently required.
Primate and rodent models of maternal separation have shown that repeated postnatal young from the mother results in long-term changes to neurohormonal systems relevant depression. To date, however, it remains unclear whether rodents experience display specific behavioural or biochemical features depression adulthood these can be prevented by treatment with antidepressant drugs. We report here maternally separated mice showed significantly shorter swim times on forced test lower levels...
Background: The functional integrity of the meniscus continually decreases with age, leading to meniscal degeneration and gradually developing into osteoarthritis (OA). In this study, we identified diagnostic markers potential mechanisms action in aging-related through bioinformatics experimental verification. Methods: Based on GSE98918 dataset, common differentially expressed genes (co-DEGs) were screened using differential expression analysis WGCNA algorithm, enrichment analyses based Gene...
Objectives/Hypothesis Cochlear implantation for patients with common cavity deformity (CCD) can be difficult, a higher incidence of intra‐ and postoperative complications; outcomes CCD are also highly variable. In this study, surgical time was compared between the traditional facial recess approach (TFRA) transmastoid slotted labyrinthotomy (TSLA). Audiological benefit using customized electrode arrays discussed. Study Design Retrospective review 13 cochlear implant (CI) CCD. Methods Six...
Ralstonia solanacearum is an extremely destructive and rebellious phytopathogen that can cause bacterial wilt diseases in more than 200 plant species. To explore discover the potential targets R. for purpose of developing new agrochemicals targeting this infection, here, we exploited a typical activity-based protein profiling technique target discovery based on probe 1 derived from bioactive oxadiazole sulfones. A total 65 specific were identified with high confidence through quantitative...
Biochemical and structural abnormalities have been reported in hippocampus of subjects with mood disorders. This study examined the organization mossy fibers anterior obtained from Stanley Neuropathology Consortium. Frozen postmortem hippocampal sections major depression, bipolar disorder, schizophrenia non-psychiatric controls were stained using Neo-Timm procedure, which selectively stains fibers. Increased Timm staining supragranular layer was found disorder relative to control subjects....
Cochlear nerve deficiency (CND) is often associated with variable outcomes of cochlear implantation (CI). We assessed previous investigations aiming to identify the main factors that determine CI outcomes, which would enable us develop predictive models. Seventy patients CND and normal cochlea who underwent surgery were retrospectively examined. First, using a data-driven approach, we collected demographic information, radiographic measurements, audiological findings, audition speech...
ABSTRACT Quinolones have been reported to induce adverse effects on articular cartilage, tendons and ligaments. However, the of quinolones menisci not revealed. The present study was test levofloxacin meniscus cells in vitro . Rabbit were administrated with different concentrations (0, 14, 28, 56, 112 224 µ m ) for 24 or 48 h, cell viability apoptosis measured. mRNA expression levels matrix metalloproteinase (MMP)‐1, MMP‐3, MMP‐13, tissue inhibitors (TIMP)‐1, TIMP‐3, Col1a1, Bcl‐2, caspase‐3...
For normal-hearing (NH) listeners, monaural factors, such as voice pitch cues, may play an important role in the segregation of speech signals multitalker environments. However, cochlear implant (CI) users experience difficulties segregating environments part due to coarse spectral resolution. The present study examined how vocal characteristics target and masking talkers influence listeners’ ability extract information from a phrase environment. Speech recognition thresholds (SRTs) were...
Ototoxic hearing loss results from hair cell death via reactive oxygen species (ROS) overproduction and consequent apoptosis. We investigated the effects of vitamin C (VC) on neomycin-induced HEI-OC1 damage, as well mechanism inhibition. cells were treated with neomycin or (VC). The indicated that VC had a protective effect death. Mechanistically, decreased ROS generation, suppressed death, increased viability. inhibited apoptosis, ameliorated reduced antiapoptotic Bcl-2 expression,...
In clinical settings, the assessment of Parkinson's disease (PD) mainly depends on doctor's experience and observation. Such often lacks unified standards may result in varied diagnoses among different doctors. To cope with this problem, we propose an objective quantified symptom tool PD mobile devices, based Unified Disease Rating Scale (UPDRS). The tool, PdAssit, assesses symptoms by actively delivering six tasks generates scores equivalent to UPDRS using machines learning models. PdAssit...
Abstract Background To investigate whether intraoperative triggered electromyographic (T-EMG) monitoring could effectively reduce the breach rate of pedicle screws and revision rate. Methods Patients with posterior screw fixation from L1-S1 were enrolled between June 2015 May 2021. The patients in whom T-EMG was utilized placed group, remaining considered non-T-EMG group. Three spine surgeons evaluated images. two groups divided into subgroups based on position (lateral/superior...