A5100645193- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sepsis Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Cardiac Arrest and Resuscitation
- Nitric Oxide and Endothelin Effects
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Cardiac Valve Diseases and Treatments
- Epigenetics and DNA Methylation
- Barrier Structure and Function Studies
- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- Neonatal Respiratory Health Research
- Autophagy in Disease and Therapy
- Aortic aneurysm repair treatments
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Cardiovascular Health and Risk Factors
- Research on Leishmaniasis Studies
- Inflammasome and immune disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Salivary Gland Disorders and Functions
- Autoimmune Neurological Disorders and Treatments
Union Hospital
2010-2024
Huazhong University of Science and Technology
2010-2024
Wuhan Union Hospital
2017-2024
Union Hospital
2023-2024
Tongji Hospital
1999-2023
Southern Medical University
2021
Nanfang Hospital
2021
University of Pittsburgh
2017-2019
Affiliated Hospital of Jining Medical University
2018
Guizhou Provincial People's Hospital
2014
A main obstacle in current valvular heart disease research is the lack of high-quality homogeneous functional valve cells. Human induced pluripotent stem cells (hiPSCs)-derived may help with this dilemma. However, there are no well-established protocols to induce hiPSCs differentiate into cells, and networks that mediate differentiation have not been fully elucidated.
Background The immunosuppression and immune dysregulation that follows severe injury includes type 2 responses manifested by elevations in interleukin (IL) 4, IL5, IL13 early after injury. We hypothesized IL33, an alarmin released tissue a known regulator of immunity, contributes to the systemic Methods findings Blunt trauma patients admitted intensive care unit level I center were enrolled observational study included frequent blood sampling. Dynamic changes IL33 soluble suppression...
Pancreatic cancer is the fourth most common cause of mortality worldwide. Furthermore, patients with pancreatic experience limited benefit from current chemotherapeutic approaches because drug resistance. Therefore, an effective therapeutic strategy for urgently required. Deguelin a natural chemopreventive that exerts potent antiproliferative activity in solid tumors by inducing cell death. However, molecular mechanisms underlying this have not been fully elucidated. Here we show deguelin...
Intracerebral hemorrhage (ICH) is a devastating medical emergency with high mortality and severe neurological deficit. ICH-related poor outcomes are due to combination of pathological processes that could be complicated by secondary insults. TWIK-related K+ channel 1 (TREK-1) two-pore-domain potassium highly expressed in the mammalian nervous system. Previous studies have shown TREK-1 channels play important roles various central system diseases. However, its role injuries after...
Objectives: The present study aimed to compare the clinicopathological features of patients with seronegative immune-mediated necrotizing myopathy (IMNM) and those positive for anti-signal recognition particle (SRP) or anti-3-hydroxy-3-methylglutarylcoenzyme-a reductase (HMGCR) antibodies. Methods: We retrospectively analyzed data IMNM treated in Neurology Department Tongji Hospital from January 1, 2013, December 31, 2019. Results: Among 117 IMNM, 30.8% (36/117) were anti-SRP antibodies,...
Abstract Sepsis is defined as infection with organ dysfunction due to a dysregulated immune response. The lung one of the most vulnerable organs at onset sepsis. Interleukin (IL)‐33 can be released by injured epithelial and endothelial cells in regulate activation infiltration. Therefore, we postulated that IL ‐33 would contribute response during Using cecal ligation puncture ( CLP ) sepsis model, show here contributes significantly both sepsis‐induced inflammation systemic inflammatory...
Fibroblastic reticular cells (FRCs), a subpopulation of stromal in lymphoid organs and fat-associated clusters (FALCs) adipose tissue, play immune-regulatory roles the host response to infection may be useful as form cell therapy sepsis. Here, we found an unexpected major role TLR9 controlling peritoneal immune recruitment FALC formation at baseline after sepsis induced by cecal ligation puncture (CLP). regulated immunity via suppression chemokine production FRCs. Adoptive transfer...
Abstract Background Necrotizing autoimmune myopathy (NAM) is pathologically characterized by myofiber necrosis and regeneration with paucity or absence of inflammatory cells in muscle biopsy. Two autoantibodies, namely anti-signal recognition particle (SRP)-antibodies anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)-antibodies, are typically specific NAM. Anti-SRP-positive NAM can be associated cardiomyopathy which responds well to immunotherapy. Here we reported an anti-SRP-antibody...
To study the effect of IL-5 on immune response and lung injury in rats with sepsis. We constructed a rat model sepsis by cecal ligation puncture (CLP). The were randomly divided into control group, sham CLP group 6 each group. With induction CLP, tissue was severely injured, water content significantly increased. Moreover, ratio CD4+/CD8+ decreased Th1/Th2 increased peripheral blood. IL-6, TNF-α, HMGB1 found to be However, injection IL-5, degree alleviated reduced. down-regulated blood...
Mechanical ventilation (MV) is frequently employed to manage respiratory failure in sepsis patients and required for the surgical management of intra-abdominal sepsis. The impact MV varies dramatically depending on tidal volume, with even moderate volume (MTV) leading ventilator-induced lung injury, whereas low (LTV) protects against sepsis-induced acute distress syndrome. Interleukin (IL)-33 known contribute injury its release can be induced by mechanical stress. To determine relationship...
Background: Toll-like receptor 4 (TLR4) is a crucial in the innate immune system and noninfectious responses. It has been reported that TLR4 participates pathological course of ischemia/reperfusion (I/R) injury. However, role process I/R injury after cardiac arrest (CA) cardiopulmonary resuscitation (CPR) still unknown. In this study, we investigated effects mutation on survival neurological outcome mouse model CA/CPR. Methods: A potassium-induced CA was performed TLR4-mutant mice (C3H/HeJ)...
Toll-like receptor 4 (TLR4) activation mediates renal injury in regional ischemia and reperfusion (I/R) models generated by clamping pedicles. However, it remains unclear whether TLR4 is causal the kidney following global I/R induced cardiac arrest (CA) cardiopulmonary resuscitation (CPR). The present study used wild‑type (C3H/HeN) TLR4‑mutant (C3H/HeJ) mice to produce CA/CPR model. CA was injection of cold KCl left untreated for different time periods. After (72 h), level blood urea...
The aim of this study was to elucidate the clinical and myopathological characteristics patients with anti-signal recognition particle (SRP) positive immune-mediated necrotizing myopathy (IMNM) overlap Sjogren's syndrome (SS).We retrospectively analyzed data anti-SRP IMNM admitted in Neurology Department Tongji Hospital between January 2011 December 2020. Patients were divided into two groups: SS group control group. features, laboratory results, histological treatment, prognosis compared...
Circadian clocks play important role in immunoregulation. We aimed to investigate cardiac circadian clock specific pathways and compare grafts procured at different timing on survival after transplantation explore novel criteria for donor selection.In primate heart, phase set enrichment analysis (PSEA) showed rhythmic transcripts were enriched antigen processing presentation during activation of rhythm. Digital sorting immune cell composition single-sample gene (ssGSEA) unused transcriptomes...
Background Extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae (K. pneumoniae) is one of the most popular pathogens that cause refractory respiratory tract infection. The genetic environment, including insertion sequences and types promoter, plays a key role in exploration mechanism prevalence dismission ESBL-producing K. isolates. aim investigation was to target analysis environment promoter bla CTX-M , SHV TEM genes harbored by Methods From February 2010 July 2011, 158 416...
Background: The usage of electronic device has two-sided effects on the health middle-aged and elderly people. Its protective cardiovascular disease (CVDs) specific mechanisms are rarely reported. Hypothesis: Moderate can reduce risk CVDs, with possible cognitive function personal well-being. Method: Participants from UK Biobank CHARLS cohort who were free 11 CVDs at recruitment included. Restricted cubic spline (RCS) analysis was employed to investigate association between time (not for...